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Zopiclone
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DRUG INFO
Zopiclone
Drug Name:
Zopiclone
Indication: For the short-term treatment of insomnia.
Pharmacology: Zopiclone is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class and is indicated for the short-term treatment of insomnia. While Zopiclone is a hypnotic agent with a chemical structure unrelated to benzodiazepines, barbiturates, or other drugs with known hypnotic properties, it interacts with the gamma-aminobutyric acid-benzodiazepine (GABABZ) receptor complex. Subunit modulation of the GABABZ receptor chloride channel macromolecular complex is hypothesized to be responsible for some of the pharmacological properties of benzodiazepines, which include sedative, anxiolytic, muscle relaxant, and anticonvulsive effects in animal models. Zopiclone binds selectively to the brain alpha subunit of the GABA A omega-1 receptor.
Mechanism Of Action: Zopiclone exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex.
Drug Category: Hypnotics and Sedatives; Anxiolytics sedatives and hypnotics; ATC:N05CF01
Brand Names/Synonyms: Amoban; Amovane; Imovance; Imovane; Lunesta; Sopivan; ZOPICLONE, 98.5%; Zimovane; Zonisamide; Zopiclona [Inn-Spanish]; Zopiclone; Zopiclone [Ban:Inn:Jan]; Zopiclonum [Inn-Latin]
Dosage Forms: TABLET
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: [8-(5-chloropyridin-2-yl)-7-oxo-2,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-9-yl]4-methylpiperazine-1-carboxylate
Chemical Formula: C17H17ClN6O3
Half Life: Approximately 5 hours
Drug Type: Approved Drug
# Accession No: APRD00356
CAS Registry Number: 43200-80-2
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Zopiclone News
(When available)
Doctors advise against reliance on sleeping pills for a good ... 16 Jan 2006
Atlanta Journal Constitution (subscription), ...popular newer sleep medications have not been shown to harm patients, but a recent analysis of 141 studies of Sonata, Ambien, Lunesta and Imovane, a Canadian ...
New Sleeping Pills Are Effective, But None Stands Out As The Best Jan 1, 2006
Medical News Today (press release), ...pharmaceutical classes. The review included 141 studies of Sonata, Ambien, Lunesta and Imovane, a Canadian brand. The medicines ...
Pipeline and Commercial Perspectives: Insomnia Dec 20, 2005
Pharmaceutical Business Review Until recently, the insomnia market has been dominated by Ambien, Sonata, and Imovane, and the older hypnotics such as benzodiazepines. ...
Sleeping pill choices a tossup Dec 19, 2005
Rocky Mountain News, ...based Practice Center, which compares the efficacy and safety of different drugs, looked at 141 studies of Sonata, Ambien, Lunesta and Imovane, a Canadian brand ...
Sleep aids equally efficient, study finds Dec 13, 2005
Detroit Free Press, ...market. Researchers reviewed 141 studies of the sleeping pills Sonata, Ambien, Lunesta and a Canadian brand called Imovane. These ...
Sleeping Pills Equally Effective Dec 13, 2005
Ivanhoe, ...from the Oregon Evidence-based Practice Center in Portland reviewed 141 studies comparing sleeping pills including Sonata, Ambien, Lunesta and Imovane. ...
Doctors say sleeping pills can help but suggest drug-free routes ... Dec 27, 2005
Sun-Sentinel.com, A recent analysis of 141 studies of Sonata, Ambien, Lunesta and Imovane, a Canadian brand, found that none stands out as the best, and that all have short-term ...
Pharmacists get ready for Medicare stresses Dec 18, 2005
Syracuse Post Standard, ...track the long-term effectiveness and safety of the new sleep aids, although there have been some reports of patients becoming dependent on Ambien and Imovane. ...
Doctors advise against reliance on sleeping pills for a good ... 16 Jan 2006
Atlanta Journal Constitution (subscription), In the ads for the new sleep drug Lunesta, a pale green luna moth — they're nocturnal — floats peacefully across the TV or computer screen, hoping to lure ...
Sleep-deprived and over-medicated Jan 15, 2006
Danbury News Times, TV viewers are now familiar with the pale green luna moth floating across the screens promoting Lunesta — one of the newest sleep drugs. ...
Sepracor Snoozes Jan 13, 2006
Smartmoney.com And while the sleep market is projected to grow by at least 8% in 2006, and Sepracor's Lunesta remains a key product, the early growth spurt Lunesta showed ...
Sepracor to defend Xopenex Jan 12, 2006
MetroWest Daily News, Xopenex is one of two key drugs developed by Sepracor. The other is Lunesta, an insomnia treatment launched last April. In the third ...
From the analyst's couch: Insomnia market Jan 9, 2006
Nature.com (subscription), Eszopiclone (Lunesta; Sepracor) is a pyrrolopyrazine developed by Sepracor as a treatment for transient and chronic insomnia, and was launched in April 2005. ...
Treating Insomnia: Sleeping Pills, Other Therapies Jan 13, 2006
WSOCtv.com, Newer medications, like Ambien®, Sonata®, Lunesta™ and Roserem™, activate a very specific area of the benzodiazepine receptor in the brain. ...
New Sleeping Pills Are Effective, But None Stands Out As The Best Jan 1, 2006
Medical News Today (press release), ...but they have different effects and no one drug stands out as the best, according to a new review of studies on drugs including Sonata, Ambien and Lunesta. ...
Stanford Tip Sheet: Watch for These Trends in 2006 Jan 12, 2006
Business Wire (press release), Three new sleeping pills, including Lunesta, were brought to market in 2005, and several more are expected to be approved by the US Food and Drug ...
Search for sweet dreams fans pharmaceutical boom Dec 25, 2005
Arkansas Democrat-Gazette (subscription), The biggest outlay came from Sepracor Inc., buying $57 million worth of TV ads in hopes of winning blockbuster status for its new Lunesta — the first ...
Is long-term use of sleeping pills OK? Dec 18, 2005
Boston Globe, So far, the only sleeping pill approved by the US Food and Drug Administration for long-term use is Lunesta, which has been shown to remain effective for at ...
Is the long-term use of sleeping pills safe? Dec 23, 2005
Baltimore Sun, So far, the only sleeping pill approved by the Food and Drug Administration for long-term use is Lunesta, which has been shown to remain effective for at least ...
Getting A Good Night of Sleep Dec 28, 2005
WNCT, Newer medications, like Ambien?, Sonata?, Lunesta? ... Studies show Ambien, Sonata and Lunesta are safe for short term use. Long-term use has not been studied. ...
Your Health … Can’t seem to get your zzz’s? Stop suffering ... Jan 9, 2006
Valley City Times Record, ...dependence and withdrawal. This class of medications include: Ambien (zolpidem), Sonata (zaleplon), and Lunesta (eszopiclone). The most ...
Pipeline and Commercial Perspectives: Insomnia Dec 20, 2005
Pharmaceutical Business Review ...market is set to grow from $3.7 billion in 2005 to $5.5 billion by 2014 (CAGR, 5.6% 200514), driven primarily by the launch and up-take of Lunesta, Rozerem and ...
Unsound sleep Dec 12, 2005
Arizona Republic, Eichling says the new types of prescription sleeping pills - Ambien, Sonata and Lunesta - are much safer than previous medications. ...
Sleep aids equally efficient, study finds Dec 13, 2005
Detroit Free Press, ...market. Researchers reviewed 141 studies of the sleeping pills Sonata, Ambien, Lunesta and a Canadian brand called Imovane. These ...
A wake-up call for the elusive Mr. Sandman Jan 5, 2006
Fort Lauderdale Sun Sentinel, The companies that make sleep medications such as Ambien and Lunesta would like you to believe that a little pill can magically summon the sandman. ...
Hypnion, Inc. Raises $20.1 Million in Extended Series B Financing Dec 19, 2005
Yahoo! News (press release) ...that Hypnion's proprietary compounds have superior efficacy and side-effect profiles than the leading marketed drugs including Ambien, Lunesta, doxepin, and ...
Selecting the Right Sleeping Pill Dec 14, 2005
WNEP-TV, A review by the oregon evidence-based practice center compared three of the most common prescription insomnia drugs sold today: Sonata, Lunesta, and Ambien. ...
Sleeping Pills Equally Effective Dec 13, 2005
Ivanhoe, ...from the Oregon Evidence-based Practice Center in Portland reviewed 141 studies comparing sleeping pills including Sonata, Ambien, Lunesta and Imovane. ...
Can't get to sleep? Drug firms take note Dec 26, 2005
Charlotte Observer, The newest drugs on the market -- Ambien CR, Sonata and Lunesta -- affect brain chemistry the same way but are choosier about the receptors they target. ...
The Best & Worst Marketing Ideas of 2005 Dec 19, 2005
Brandweek Magazine, ...taste. The NHL made some bold changes and scored a strong comeback. Even the drug industry came up with a winner in Lunesta. In ...
Sleeping pill choices a tossup Dec 19, 2005
Rocky Mountain News, Oregon Evidence-based Practice Center, which compares the efficacy and safety of different drugs, looked at 141 studies of Sonata, Ambien, Lunesta and Imovane ...
Catch a good night’s sleep Dec 13, 2005
Ocala.com, Doctors are still not sure how non-narcotic sleeping drugs, such as top-seller Ambien and Lunesta, actually work, Dement said, except that ``they sedate you ...
New Pharmaceutical Treatment Options in the Elderly Dec 14, 2005
Medscape (subscription) However, it can only be used intravenously and thus has been reserved for complicated infections of the abdomen, skin, and wounds. Eszopiclone (Lunesta). ...
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