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Vitamin B3 (Niacin)
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DRUG INFO
Vitamin B3 (Niacin)
Drug Name:
Vitamin B3 (Niacin)
Indication: For the treatment of type IV and V hyperlipidemia. It is indicated as ajunctive therapy.
Pharmacology: Niacin and niacinamide are indicated for prevention and treatment of vitamin B3 deficiency states. Vitamin B3 (Niacin) also acts to reduce LDL cholesterol, triglycerides, and HDL cholesterol. The magnitude of individual lipid and lipoprotein responses may be influenced by the severity and type of underlying lipid abnormality. The increase in total HDL is associated with a shift in the distribution of HDL subfractions (as defined by ultra-centrifugation) with an increase in the HDL2:HDL3 ratio and an increase in apolipoprotein A-I content. Vitamin B3 (Niacin) treatment also decreases the serum levels of apolipoprotein B-100 (apo B), the major protein component of the VLDL (very low-density lipoprotein) and LDL fractions, and of lipoprotein-a, a variant form of LDL independently associated with coronary risk.
Mechanism Of Action: Niacin binds to Nicotinate D-ribonucleotide phyrophsopate phosphoribosyltransferase, Nicotinic acid phosphoribosyltransferase, Nicotinate N-methyltransferase and the Niacin receptor. Niacin is the precursor to nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are vital cofactors for dozens of enzymes. The mechanism by which niacin exerts its lipid lowering effects is not entirely understood, but may involve several actions, including a decrease in esterification of hepatic triglycerides. Niacin treatment also decreases the serum levels of apolipoprotein B-100 (apo B), the major protein component of the VLDL (very low-density lipoprotein) and LDL fractions.
Drug Category: Vasodilator Agents; Antilipemic Agents; Vitamins (Vitamin B Complex); ATC:C04AC01; ATC:C10AD02
Brand Names/Synonyms: -Pyridinecarboxylic Acid; -Pyridylcarboxylic Acid; Acide Nicotinique; Acidum Nicotinicum; Akotin; Anti-Pellagra Vitamin; Apelagrin; Bionic; Daskil; Davitamon Pp; Diacin; Direktan; Efacin; Kyselina Nikotinova; Linic; M-Pyridinecarboxylic Acid; NAH; NICO; N
Dosage Forms: CAPSULE; CAPSULE (EXTENDED-RELEASE); ORAL SOLUTION; TABLET; TABLET (EXTENDED-RELEASE); INJECTION
Absorption: Both nicotinic acid and nicotinamide are efficiently absorbed from the stomach and small intestine
Interactions: Interactions for Vitamin B3 (Niacin):
Antihypertensive Therapy: Nicotinic acid may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension.
Aspirin: Concomitant aspirin may decrease the metabolic clearance of nicotinic acid. The clinical relevance of this finding is unclear.
Other: Concomitant alcohol or hot drinks may increase the side effects of flushing and pruritus and should be avoided at the time of drug ingestion.
Chemical IUPAC Name: pyridine-3-carboxylic acid
Chemical Formula: C6H5NO2
Half Life: 20-45 minutes.
Drug Type: Approved Drug
# Accession No: APRD00536
CAS Registry Number: 59-67-6
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Vitamin B3 (Niacin) News
(When available)
Walker says he's true champion 15 Jan 2006
Australian, Davitamon Lotto rider Henk Vogels crossed the line in fifth place, the same time as Van Hout, and was furious when he learned that he could have still won the ...
Golden dawn for local team with global aim 15 Jan 2006
Australian, After the Tour Down Under -- where it will compete against international teams including Belgium's Davitamon Lotto, France's Credit Agricole and the Spanish ...
Saturday's EuroFile: Tours go their own route; Heras appeals Jan 14, 2006
VeloNews, Robbie McEwen said he'll likely race the Tour of Flanders this year, not with the intention of winning but helping Davitamon-Lotto teammate Peter Van Petegem. ...
Bates has the Blahniks to go with the legs Jan 13, 2006
Australian, Defending champion Robbie McEwen, leader of the European Davitamon-Lotto team, will be among the favourites, but will face strong opposition from fellow ...
Bannan confident about Games cycling Jan 11, 2006
Sydney Morning Herald, Powerful Belgian outfit Davitamon-Lotto, for example, will build a team around McEwen because of his world-class sprinting ability. ...
Amgen Tour of California Jan 13, 2006
OUTDOORNEWSWIRE, Three-time USPRO National Road Champion and Los Angeles-area native "Fast Freddie" Rodriguez's Davitamon-Lotto (BEL) team will be joined in competition with ...
Belgian trio hot to trot in 'heaven' Jan 8, 2006
Advertiser Adelaide, TEAM Davitamon-Lotto's Belgian connection may have looked like they were lapping up the good life at Memorial Drive yesterday but it was no more than a moment ...
An interview with Chris Horner, December 20, 2005 Dec 19, 2005
Cyclingnews.com ...the big moments. Cyclingnews' Les Clarke got the word on '05 from Davitamon-Lotto's latest American import. Last time Cyclingnews ...
Rabobank confirm deal with Ardila Dec 13, 2005
Cyclingpost.com, AMSTERDAM, Dec 13 (CP) - Dutch ProTour team Rabobank have finally confirmed the transfer of Colombian Davitamon-Lotto rider Mauricio Ardila. ...
First Edition Cycling News Dec 21, 2005
Cyclingnews.com There was better news for Belgian Jan Kuyckx (Davitamon-Lotto), who tested positive for ephedrine and norpseudoephedrine during the Ster Elektrotoer earlier ...
First Edition Cycling News Jan 2, 2006
Cyclingnews.com Davitamon-Lotto sprinter Robbie McEwen will commence his Australian campaign on Wednesday, January 4 when he contests the Jayco Geelong Bay Classic in Melbourne ...
Monday's EuroFile: Mancebo shifts to Switzerland; Illes Balears ... Jan 2, 2006
VeloNews, After losing the services of top rider Josep Jufré to Davitamon-Lotto, Spanish continental team Relax-Fuenlabrada has added two riders to its 2006 roster. ...
Wednesday's EuroFile: Valverde wants Tour; Milram to debut at TDU ... Jan 4, 2006
VeloNews, Down Under. Other teams include Liberty Seguros, Ag2r, Bouygues Telecom, Credit Agricole, Davitamon-Lotto and Liquigas. Riders from ...
EuroTrash Thursday! Jan 5, 2006
PezCycling News Seven ProTour teams will be taking to the start line - Liberty Seguros-Wurth, Davitamon Lotto, AG2R Prevoyance, Bouygues Telecom, Credit Agricole, Liquigas and ...
Top cyclists reject Games Dec 22, 2005
FOX SPORTS, The duo are unavailable for the March Games after discussions with European professional teams Davitamon-Lotto and T-Mobile, respectively. ...
Cyclists in blow-out Dec 22, 2005
Melbourne Herald Sun, Evans and Rogers are unavailable for the March Games after discussions with European professional teams Davitamon-Lotto and T-Mobile, respectively. ...
CHASING LANCE: The 2005 Tour de France and Lance Armstrong's Ride ... Dec 27, 2005
International Herald Tribune, Back in bicycle racing as a directeur sportif for the Davitamon team in Belgium, Peiper is also able to write: "I was actually good at this job and would be ...
Riders won't choose country Dec 28, 2005
Brisbane Courier Mail, Triple world time trial champion Michael Rogers (T-Mobile) and Tour de France hero Evans (Davitamon-Lotto) have informed national selectors they are unavailable ...
JACOB'S CREEK TOUR DOWN UNDER Dec 15, 2005
SFCPressPoint (press release), ...sprints to be explosive with 2005 Tour de France green jersey champion, Thor Hushovd (Credit Agricole) and Queensland's Robbie McEwen, (Davitamon-Lotto) who ...
Great White still has bite Dec 17, 2005
Queensland Sunday Mail, Two champions of the road in Queenslander Robbie McEwen (Davitamon Lotto) and Brad McGee of the Francaise des Jeux team, each reportedly earned more than $1 ...
Four Pro Tour teams confirmed in the Tour of the Algarve Dec 16, 2005
Regiao Sul, ...of the Discovery Channel, without the presence of the retired Lance Armstrong, but with José Azevedo and José Luís Rubiera; the Davitamon-Lotto, with Van ...
Ardila to lead Rabobank at Giro Dec 22, 2005
Cyclingpost.com, The cyclist, who rode for Davitamon-Lotto, signed a contract with Rabobank for two seasons, after his good performance at the 2005 editions of the Giro and the ...
JACOB'S CREEK TOUR DOWN UNDER Dec 29, 2005
SFCPressPoint (press release), The team list includes seven ProTour teams - Liberty Seguros-Wurth, Davitamon Lotto, AG2R Prevoyance, Bouygues Telecom, Credit Agricole, Liquigas and Milram ...
Nicotin Products Might Harm Unborn Baby Jan 2, 2006
Zaman Online, By Anadolu News Agency (aa), New York. The consumption of nicotine products during the first 12 weeks of pregnancy apparently may ...
Trees and People Dec 24, 2005
Napa Valley Register, ...chemicals called neonicotinoids. The "nicotin" part of the name refers to the related, naturally occurring chemical, nicotine. Some of ...
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