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Vindesine
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DRUG INFO
Vindesine
Drug Name:
Vindesine
Indication: For the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia and acute panmyelosis
Pharmacology: Vindesine is indicated for the treatment of acute lymphocytic leukemia of childhood that is resistant to vincristine and non-oat cell lung cancer.Vindesine causes the arrest of cells in metaphase mitosis. It is three times more potent than vincristine and nearly 10 times more potent than vinblastine in causing mitotic arrest in in vitro studies at doses designed to arrest from 10 to 15% of the cells in mitosis. Vindesine and vincristine are approximately equipotent at dose levels that arrest 40 to 50% of the cells in mitosis. Unlike vinblastine, vindesine produces very few postmetaphase cells. Vindesine has demonstrated activity in patients who have relapsed while receiving multiple-agent treatment that included vincristine.
Mechanism Of Action: Vindesine acts by causing the arrest of cells in metaphase mitosis through its interaction with tubulin. The drug is cell-cycle specific for the S phase.
Drug Category: Antineoplastic Agents; ATC:L01CA03
Brand Names/Synonyms: CHEMBANK3015; DAVA; Desacetylvinblastine Amide Sulfate; Desacetylvinblastine Amide Sulfate Compound with Mannitol; Eldesine; Eldisine; VINDESINE; Vindesine; Vindesine Sulfate
Dosage Forms: IV Solution; POWDER FOR SOLUTION
Absorption: Not Available
Interactions: Drug Interactions:
Vindesine can interact with the drugs of the following categories:
- Blood dyscrasia: can cause unpredictable myelotoxicity
- Bone marrow depressants: can cause a predictable dose-related myelotoxicity
- Radiation therapy: may cause marrow depression
- Neurotoxic medications: can cause neurologic toxicity
- Phenytoin: can increase seizure activity
- Live virus vaccines: may potentiate the replication of the vaccine virus, may increase the side effects of the vaccination,
and decrease patient's response to the vaccine
- Mitomycin-C: may cause shortness of breath and bronchospasm
- Killed virus vaccines: may decrease patient's response to the vaccine
Chemical IUPAC Name: Not Available
Chemical Formula: C43H55N5O7
Half Life: 24 hours.
Drug Type: Approved Drug
# Accession No: APRD00392
CAS Registry Number: 59917-39-4
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Vindesine News
(When available)
Her name is Kari and she's an 'Earl' girl 15 Jan 2006
The Saratogian, ...'So I packed my stuff and left within a week and found myself in LA I interviewed with (casting director) Dava Waite and she hired me on the spot. ...
Dava Sobel on The Planets Dec 21, 2005
Science & Theology News, By Britt Peterson. Her most recent book, The Planets, takes the reader on a guided tour of our solar system. She told Science & Theology ...
Dava Sobel takes another leap into space with 'The Planets' Dec 14, 2005
Pioneer Press, BY SANDY BAUERS. Dava Sobel has been moving ever-outward into space. Her first book, "Longitude: The True Story of the Lone Genius ...
The book that inspired me Jan 9, 2006
Business Standard, ...gold out of it. A book that helped me was The Illustrated Longitude by Dava Sobel and William JH Andrewes. It discusses the discovery ...
From Sundials To Cell Phones Jan 1, 2006
CBS News ...times when people weren't distracted by neon lights, television, street lights, the sky was the greatest show on earth," says science writer Dava Sobel, whose ...
Lady Orioles shut down Rose Hill Jan 11, 2006
Augusta Daily Gazette, After Rose Hill's Dava Logsdon scored the first points of the game, Rainey Nickel responded with three straight baskets to give Augusta a 7-2 edge. ...
New Venue Set For Christopher Awards Gala On March 16, 2006 Jan 10, 2006
PR Newswire (press release), Hayao Miyazaki, Stephen Daldry, and Ken Burns; authors David McCullough, Dominique Lapierre, Stephen E. Ambrose, Jonathan Kozol and Dava Sobel; children's book ...
EHS girls squad remain searching for first victory Jan 9, 2006
El Dorado Times, One of those was 5-foot-9 center Madison Lucas, who controlled the middle for Rose Hill with Dava Logsdon (another junior) and finished with 14 points. ...
No team scores Jan 7, 2006
U of M Gophersports, Williams, Bemidji State ND Round 1, Flight 2 1 Lyndon McDowell, Unattached 21-2 (6.45m)q 2 Tre Sayles, 1, Concordia St Paul 20-11 1/4 (6.38m)q 3 Dava Ralph, 3 ...
Cirque Hawaii in town Dec 20, 2005
KHON2, ...seats all year long. Maybe their luck will hold out, just like it has for trapeze artist Dava Attantsetseg. The Mongolian native ...
Out of this world: Nasa funds revolutionary ideas Jan 3, 2006
Guardian Unlimited, ...sensors". The iconic but clunky spacesuit is also set for a makeover. Dava Newman, at MIT, presented the Bio-Suit System. Dr Cassanova ...
Davao City cagers, spikers down foes Jan 7, 2006
Sun.Star, The Davao City volleybelles walloped Davao del Sur, 25-1, 25-10, 25-0 in their debut in the meet sanctioned by the Davao Amateur Volleyball Association (Dava). ...
KGSO broadcasting City League boys, girls Jan 6, 2006
The Wichita Eagle, ...win.". Rose Hill has three players averaging double figures -- Kristen Ozbun (12.2), Dava Logsdon (10.8) and Erica Herman (10.7). ...
Peter L. Vescio, 84, 12/31/2005 Jan 2, 2006
Oswego Daily News, Sam Vescio both of Fulton, four sisters Angie Talamo, Rose Clark, Eleanor McGraw, June (Dick) Johnston all of Fulton, four grandchildren, Dava, Jennifer, Tammie ...
2006 ICA Grants and Awards Jan 4, 2006
Boise Weekly, Pomona, CA. $960 to Dava Dahlgran for framing 40 pieces of artwork for an exhibition at the Willowtree Gallery in Idaho Falls. $4,950 ...
Weighing the World The Quest to Measure the Earth Dec 31, 2005
San Francisco Chronicle, As masters of the science-history subgenre such as Dava Sobel know, knotty scientific principles like triangulation and zenith-sector measurement can only be ...
Marriage Licenses Dec 18, 2005
Arkansas Democrat-Gazette (subscription), Renaldo Nemiah Colbert, 23, and Jackie Laverne Heath, 27, both of Fayetteville. Wesley Patrick Johnson, 22, and Dava Latrice Hartzo, 31, both of Fayetteville. ...
Rizal should be youth’s role model, says President Dec 30, 2005
Manila Bulletin, Day commemoration were Rhea Mae Rifani, Benjie Rivera, Edward Folayang and Rexel Nganghayna, wushu; Jouveliet Chalem, boxing; Helen Dava, judo; Christabel ...
`Black Nativity' full of soul Dec 18, 2005
Akron Beacon Journal, The holy family's white costuming has been created by Dava Cansler, while Morris Cammon created the rest of the cast's costumes. ...
2005 A Space Odyssey Dec 19, 2005
Globe and Mail, In Longitude, her 1995 book, science writer Dava Sobel recounted the fascinating tale of John Harrison, the 18th-century English inventor who built the first ...
Rose Hill Rockets notch victories against Buhler Dec 19, 2005
Augusta Daily Gazette, Friday night. Erica Herman led all scorers with 20 points. Dava Logsdon netted 16, and Kristen Ozbun added 15. The Lady Rockets ...
COOL DEAL / Raj Tents offer more than your garden-variety shade Dec 28, 2005
San Francisco Chronicle, Graphic designer Dava Guthmiller sets the tone in fedora and bodysuit with a plunging neckline as she steps from a vintage car (above), while Louise Mann of ...
The year of publishing safely Dec 30, 2005
Guardian Unlimited, ...to be more than one-hit wonders, no one promising to be a durable commercial star emerged in 2005; and neither was there a Lynne Truss, or Dava Sobel-like ...
Smith: Times Sports Personality of the Year Dec 21, 2005
The Times Newspaper Online, ...contributing to me performing the way I did and eventually receiving the awards that I have and also to the coaching staff and the executive of the DAVA, but I ...
Midstate births in October, November and December 2005 Dec 13, 2005
The Tennessean, Givens Reid. Silva, Richard and Dava of Nashville have named their son, born Nov.29 at Baptist Hospital, Richard Manning Silva. Steele ...
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