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Vigabatrin
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DRUG INFO
Vigabatrin
Drug Name:
Vigabatrin
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Indication: Used for the treatment of refractory seizure disorders (epilepsy, complex partial seizures, seconday generalized seizures and infantile spasms in West syndrome
Pharmacology: Vigabatrin, although chemically unrelated to other anticonvulsants, is an anticonvulsant used to treat tonic-clonic seizures, complex partial seizures, absence seizures, myoclonic seizures, bipolar disorder, and migraines. It inhibits the catabolism of GABA.
Mechanism Of Action: Vigabatrin is an irreversible inhibitor of gamma-aminobutyric acid transaminase (GABA-T), the enzyme responsible for the catabolism of GABA. Gamma-aminobutyric acid (GABA), is an inhibitory neurotransmitter in the CNS. This inhibition increases the level of GABA in the synapses. Vigabatrin is a racemic compound, and its [S]-enantiomer is pharmacologically active. Vigabatrin may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. Vigabatrin is an analog of GABA but is not a receptor agonist.
Drug Category: Anticonvulsants; Enzyme Inhibitors; ATC:N03AG04
Brand Names/Synonyms: CHEMBANK1798; GVG; Gamma-Vinyl Gaba; Sabril; Vigabatrin; Vigabatrin [Usan:Ban:Inn]; Vigabatrina [Spanish]; Vigabatrine; Vigabatrine [French]; Vigabatrinum [Latin]; [Latin]; [Usan:Ban:Inn]
Dosage Forms: POWDER; TABLETS
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: 4-aminohex-5-enoic acid
Chemical Formula: C6H11NO2
Half Life: 5-8 hours
Drug Type: Approved Drug
# Accession No: APRD00282
CAS Registry Number: 60643-86-9
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