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Vasopressin
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DRUG INFO
Vasopressin
Drug Name:
Vasopressin
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Indication: Enuresis;Polyuria;Diabetes insipidus;Polydipsia;Oesophageal varices with bleeding
Pharmacology: Vasopressin is an antidiuretic hormone indicated for the prevention and treatment of postoperative abdominal distention, in abdominal roentgenography to dispel interfering gas shadows, and in diabetes insipidus. Vasopressin can cause contraction of smooth muscle of the gastrointestinal tract and of all parts of the vascular bed, especially the capillaries, small arterioles and venules. It has less effect on the smooth musculature of the large veins. Vasopressin may also be used to control bleeding in some forms of von Willebrand disease and to treat extreme cases of bed wetting in children. It may also play a role in memory formation although the mechanism is unknown.
Mechanism Of Action: Vasopressin acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of vasopressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.
Drug Category: Antidiuretics; Vasoconstrictor Agents; Pituitary (68:28.00); ATC:H01BA01
Brand Names/Synonyms: Argiprestocin; Vasopressin; Arginine oxytocin; Pitressin tannate; Arginine vasotocin; Vasotocin; Vasopressin, isoleucyl; 3-Isoleucyl vasopressin; Vasopressin, non-mammalian; Pitressin; Pressyn
Dosage Forms: LIQUID
Absorption: Not Available
Interactions: Interactions for Vasopressin:
1) The following drugs may potentiate the antidiuretic effect of vasopressin when used concurrently: carbamazepine; chlorpropamide; clofibrate; urea; fludrocortisone; tricyclic antidepressants.
2) The following drugs may decrease the antidiuretic effect of vasopressin when used concurrently: demeclocyline; norepinephrine; lithium; heparin, alcohol.
3) Ganglionic blocking agents may produce a marked increase in sensitivity to the pressor effects of vasopressin.
Chemical IUPAC Name: 1-[[19-amino-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-13-(1-methylpropyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-4-yl]carbonyl]-N-[1-(carbamoylmethylcarbamoyl)-4-guanidino-butyl]-pyrrolidine-2-carboxamide
Chemical Formula: C43H67N15O12S2
Half Life: 10-20 minutes
Drug Type: Approved Drug
# Accession No: BIOD00110
CAS Registry Number: 11000-17-2
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