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Uracil Mustard
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DRUG INFO
Uracil Mustard
Drug Name:
Uracil Mustard
Indication: Used for its antineoplastic properties
Pharmacology: Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Uracil Mustard-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Mechanism Of Action: After activationm it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
Drug Category: Antineoplastic Agents;
Brand Names/Synonyms: Aminouracil Mustard; CB-4835; Chlorethaminacil; Demethyldopan; Desmethyldopan; Haemanthamine; Nordopan; Rcra Waste Number U237; U 8344; U-8344; URACIL MUSTARD; Uracil Mustard; Uracil Nitrogen Mustard; Uracillost; Uracilmostaza; Uramustin; Uramustine
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: 5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione
Chemical Formula: C8H11Cl2N3O2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00130
CAS Registry Number: 66-75-1
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Uracil Mustard News
(When available)
From a cause, a cure Jan 8, 2006
Boston Globe, ...first performed at Yale in the mid-1940s, on a patient with Hodgkin's disease, which regressed dramatically after treatment with nitrogen mustard, a related ...
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