|
Torasemide
resources
|
|
|
|
|
|
DRUG INFO
Torasemide
Drug Name:
Torasemide
Indication: For the treatment of hypertension, edema induced by congestive heart failure or renal disease and ascites assocated with hepatic disease
Pharmacology: Torasemide, a monosulfonamyl loop diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Torasemide is used alone or with atenolol in the management of hypertension and edema. Micropuncture studies in animals have shown that torsemide acts from within the lumen of the thick ascending portion of the loop of Henle, where it inhibits the Na+/K+/2CI--carrier system.
Mechanism Of Action: Torasemide acts on the Na+/K+/2Cl- co-transporter. It inhibits sodium ion transport across the renal tubular epithelium in the cortical diluting segment of the ascending limb of the loop of Henle. By increasing the delivery of sodium to the distal renal tubule, Torasemide indirectly increases potassium excretion via the sodium-potassium exchange mechanism
Drug Category: Diuretics; Antihypertensive Agents; ATC:C03CA04
Brand Names/Synonyms: AC 4464; CCRIS 6736; Demadex; JDL 464; Luprac; TORSEMIDE; Torasemida [Inn-Spanish]; Torasemide; Torasemidum [Inn-Latin]; Torsemide; Torsemide [Usan]
Dosage Forms: LIQUID; TABLET
Absorption: Bioavailability is ~80%, serum concentration peaks after ~1 hour
Interactions: Not Available
Chemical IUPAC Name: 1-[4-(3-methylphenyl)aminopyridin-3-yl]sulfonyl-3-propan-2-yl-urea
Chemical Formula: C16H20N4O3S Not Available
Half Life: 3.5 hours
Drug Type: Approved Drug
# Accession No: APRD00217
CAS Registry Number: 56211-40-6
|
|
|
|
|
|
Torasemide News
(When available)
Penwest Announces Results of Phase IIa Trial for PW2132 Dec 20, 2005
PharmaLive.com (press release), ...dosing. The study also included a comparator arm of DEMADEX(R) 200 mg, which is the branded immediate release version of torsemide. ...
|
|
|
