Thiopental resources

DRUG INFO
Thiopental

Drug Name: Thiopental

Indication: Intravenous anaesthetic

Pharmacology: Thiopental, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.

Mechanism Of Action: Thiopental binds at a distinct binding site associated with a Cl^- ionopore at the GABA_A receptor, increasing the duration of time for which the Cl^- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Drug Category: Anesthetics; Hypnotics and Sedatives; Anticonvulsants; General Anesthetics; ATC:N01AF03; ATC:N05CA19

Brand Names/Synonyms: Dea No. 2100; Farmotal; Intraval; Nesdonal; Penthiobarbital; Pentothal; Pentothiobarbital; Robinax; Thiomebumal; Thionembutal; Thiopental; Thiopentobarbital; Thiopentobarbitone; Thiopentobarbituric Acid; Thiopentone; Thiothal; Tiopentale; Tiopentale [Italian]; Trapanal

Dosage Forms: POWDER FOR SOLUTION

Absorption: Not Available

Interactions: DrugBank: Interactions for Thiopental

Interactions for Thiopental:

The following drug interactions have been reported with thiopental.

Drug	Effect
Probenecid	Prolonged action of thiopental
Diazoxide	Hypotension
Zimelidine	Thiopental antagonism
Opioid analgesics	Decreased antinociceptive action
Aminophylline	Thiopental antagonism
Midazolam	Synergism

Chemical IUPAC Name: 5-ethyl-5-(1-methylbutyl)-2-sulfanyl-1H-pyrimidine-4,6-dione

Chemical Formula: C11H18N2O2S

Half Life: 3-8 hours

Drug Type: Approved Drug

# Accession No: APRD00660

CAS Registry Number: 76-75-5

Thiopental News
(When available)

Judges deny Allen's appeal -- reprieve sought Supreme Court last ...  16 Jan 2006
San Francisco Chronicle, Sodium pentothal will put him to sleep, pancuronium bromide will stop his breathing, and potassium chloride will stop his heart.

Attorney to court: Lethal injection cruel  Jan 11, 2006
Pensacola News Journal, Florida's lethal injection process calls for injecting inmates with at least two grams of sodium pentothal to render them unconscious before administering ...

Does money buy justice?  Jan 9, 2006
Caribbean Net News, Thiopental Sodium, also called Sodium Pentothal does make the recipient talk willingly but it actually does not mean everything he says is the actual truth. ...

- By Our Correspondent  Dec 27, 2005
The Asian Age, In the narcoanalysis test, Salem will be administered drugs like sodium amytal or sodium pentothal, the "truth serum" that make the subject speak freely, in ...

Jacksonville gives chowdah heads a laugh  Jan 8, 2006
Orlando Sentinel, ...the Jags. But if you injected Paul Tagliabue with sodium pentothal, he'd have to admit he was thrilled with the outcome. It's not ...

Serial blasts: Dar, two others to undergo narco-analysis test  Dec 26, 2005
Outlook (subscription), During the narco test the accused is put in a semi-conscious state by injecting him with a chemical Sodium Pentothal or 'truth serum', which prompts him to ...

Boy, 17, dies after oral surgery in Hempstead  Dec 23, 2005
New York Daily News, ...sedatives used. Como is certified to administer the type of sedative used in the procedure, called Pentothal, Farrell said. "He ...

Abu Salem brought to Bangalore for polygraph test  Dec 28, 2005
NewKerala.com, ...against him. According to experts, Abu Salem will be administered truth serum, which includes a dose of sodium pentothal. When he ...

Thiopental resources

DRUG INFO Thiopental

Interactions for Thiopental:

DRUG INFO
Thiopental