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Thiamylal
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DRUG INFO
Thiamylal
Drug Name:
Thiamylal
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Indication: Used for the production of complete anaesthesia of short duration; For the induction of general anaesthesia;For inducing a hypnotic state
Pharmacology: Thiamylal, a barbiturate, is used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines, and pain. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.
Mechanism Of Action: Thiamylal binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Drug Category: Anesthetics; Hypnotics and Sedatives; ATC:M01A
Brand Names/Synonyms: Dea No. 2100; Surital; Thiamylal; Thiamylal [Usan]; Thioseconal
Dosage Forms: POWDER FOR SOLUTION
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: 5-(1-methylbutyl)-5-prop-2-enyl-2-sulfanyl-1H-pyrimidine-4,6-dione
Chemical Formula: C12H18N2O2S
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00154
CAS Registry Number: 77-27-0
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