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Terconazole
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DRUG INFO
Terconazole
Drug Name:
Terconazole
Indication: Candidiasis (a yeast-like fungal infection) of the vulva and vagina
Pharmacology: Terconazole is a triazole antifungal agent available for intravaginal use. It is structurally related to imidazole-derivative antifungal agents, although terconazole and other triazoles have 3 nitrogens in the azole ring.
Mechanism Of Action: Terconazole may exert its antifungal activity by disrupting normal fungal cell membrane permeability. Terconazole and other triazole antifungal agents inhibit cytochrome P450 14-alpha-demethylase in susceptible fungi, which leads to the accumulation of lanosterol and other methylated sterols and a decrease in ergosterol concentration.
Drug Category: Antifungals; Antifungals; ATC:G01AG02
Brand Names/Synonyms: Fungistat; Gyno-Terazol; Terazol; Terazol 3; Terazol 7; Terconazole; Tercospor; Triaconazole
Dosage Forms: Vaginal cream and Vaginal suppositories
Absorption: Following intravaginal administration of terconazole in humans, absorption ranged from 5-8% in three hysterectomized subjects and 12-16% in two non-hysterectomized subjects with tubal ligations
Interactions:
DrugBank: Interactions for Terconazole
Interactions for Terconazole:
TERAZOL 7 Vaginal Cream 0.4% and TERAZOL 3 Vaginal Suppositories 80 mg
The therapeutic effect of these products is not affected by oral contraceptive usage.
TERAZOL 3 Vaginal Cream 0.8%
The levels of estradiol (E2) and progesterone did not differ significantly when 0.8% terconazole
vaginal cream was administered to healthy female volunteers established on a low dose oral contraceptive.
Chemical IUPAC Name: 1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)piperazine
Chemical Formula: C26H31Cl2N5O3
Half Life: 6.9 hours (range 4.0-11.3)
Drug Type: Approved Drug
# Accession No: APRD00659
CAS Registry Number: 67915-31-5
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Terconazole News
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