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Tenecteplase
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DRUG INFO
Tenecteplase
Drug Name:
Tenecteplase
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Indication: For treatment of myocardial infarction and lysis of intracoronary emboli
Pharmacology: Cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction.
Mechanism Of Action: TNKase cleaves the Arg/Val bond in plasminogen to form plasmin. This in turn leads to the degradation of blood clots.
Drug Category: Thrombolytic Agents
Brand Names/Synonyms: Tissue-type plasminogen activator precursor;tPA;t- PA;t-plasminogen activator;Alteplase;Reteplase; TNKase (Genentech Inc)
Dosage Forms: POWDER FOR SOLUTION
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: Human tissue plasminogen activator
Chemical Formula: C2561H3919N747O781S40
Half Life: 1.9 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).
Drug Type: Approved Drug
# Accession No: BIOD00019
CAS Registry Number: 105857-23-6
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