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Temozolomide
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DRUG INFO
Temozolomide
Drug Name:
Temozolomide
Indication: For the treatment of adult patients diagnosed with anaplastic astrocytoma who have relapsed following chemotherapy
Pharmacology: Temozolomide is an antineoplastic agent. It causes death of of rapidly replicating cells, especially malignant cells, leading to regression or slowed tumor growth.
Mechanism Of Action: Temozolomide is not active until it is converted at physiologic pH to the active form, 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC). The cytotoxicity of MTIC is due to alkylation of DNA at the O6 and N7 positions of guanine.
Drug Category: Antineoplastic Agents; ATC:L01AX03
Brand Names/Synonyms: AIDS-129717; AIDS129717; CHEMBANK1819; Methazolastone; NSC362856; Temodal; Temodar; Temozolamide; Temozolodida [Spanish]; Temozolomide; Temozolomide [Ban:Inn]; Temozolomidum [Latin]
Dosage Forms: CAPSULE
Absorption: Rapid and complete absorption in the gastrointestinal tract
Interactions:
DrugBank: Interactions for Temozolomide
Interactions for Temozolomide:
Administration of valproic acid decreases oral clearance of temozolomide by about 5%. The clinical implication of
this effect is not known.
Patients with Severe Hepatic or Renal Impairment
Caution should be exercised when TEMODAR Capsules are administered to patients with severe hepatic or renal
impairment.
Chemical IUPAC Name: 4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide
Chemical Formula: C6H6N6O2
Half Life: ~1.8 hours .
Drug Type: Approved Drug
# Accession No: APRD00557
CAS Registry Number: 85622-93-1
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Temozolomide News
(When available)
Bryony is full of hope Dec 20, 2005
Manawatu Standard, The Manawatu community in October raised some $40,000 to ensure the 33-year-old mum could try the latest unsubsidised chemotherapy drug Temodal, in an attempt ...
Benefit breakfast, auction, bake sale set for Lois Dekoski Jan 13, 2006
Huron Daily Tribune, ...tumor. In November of 2004, Lois underwent a combined treatment of Temodar (a form of oral chemotherapy) and radiation. On Dec. ...
Most Improved Pipeline: Schering-Plough Jan 10, 2006
R&D Directions (subscription), ..."We are pleased with the continued progress on Temodar, our treatment for certain types of brain tumors, and with the work of our oncology team to build a ...
Gleevec® plus Hydroxyurea Beneficial for Some Patients with ... Dec 20, 2005
Cancer Consultants (press release), ...the trial. They had had received prior treatment with radiation therapy and Temodar® (temozolomide)-based chemotherapy. The following ...
Keryx Biopharmaceuticals, Inc. Announces Appointment of Senior ... Jan 4, 2006
PR Newswire (press release), ...treatment of malignant melanoma, hairy cell leukemia, AIDS-related Kaposi's sarcoma, chronic hepatitis C and chronic hepatitis B, (2) temodar(R) (temozolomide ...
Investigative report reveals how Big Pharma gets special tax ... Jan 3, 2006
Newstarget.com, For instance, PSI covered 50% of a copayment for a six-week course Temodar, a Schering-Plough treatment that costs $1,272 per week, for a New Jersey woman with ...
£10,000 for two years life Dec 30, 2005
Sunderland Echo, Without the drug, known as Temozolamide, the 66-year-old retired newsagent might not see next Christmas as the aggressive tumour, now inoperable, continues to ...
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