Indication: For the short-term treatment of insomnia (generally 7-10 days).
Pharmacology: Temazepam is a benzodiazepine used as a hypnotic agent in the management of insomnia. Temazepam produces CNS depression at limbic, thalamic, and hypothalamic levels of the CNS. Temazepam increases the affinity of the neurotransmitter gamma-aminobutyric acid (GABA) for GABA receptors by binding to benzodiazepine receptors. Results are sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action.
Mechanism Of Action: Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
Drug Category: Anti-anxiety Agents; Adjuvants, Anesthesia; Benzodiazepines; GABA Modulators; ATC:N05CD07
Absorption: Well absorbed, minimal first-pass metabolism.
Interactions:
DrugBank: Interactions for Temazepam
Interactions for Temazepam:
The pharmacokinetic profile of temazepam does not appear to be altered by orally administered cimetidine dosed
according to labeling.
Chemical IUPAC Name: 10-chloro-4-hydroxy-6-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-2,8,10,12-tetraen-5-one
Chemical Formula: C16H13ClN2O2
Half Life: 10-20 hours
Drug Type: Approved Drug
# Accession No: APRD00676
CAS Registry Number: 846-50-4
Temazepam News (When available)
Max Green Alchemy Introduces Scalp Rescue Hair Styling Gel16 Jan 2006 NPIcenter (press release), San Francisco, California (January 9, 2006) Max Green Alchemy Ltd introduces Scalp Rescueâ„¢ Styling Gel, a 100% plant-derived hair styling gel made without ...
GEL continues to do well e16 Jan 2006 Barbados Advocate, Caribbean) Limited, Caribbean Label Crafts Limited, and the Guyana-based BEV Processors Incorporated are the manufacturing entities within the GEL Group. ...
Rabbit magical in win16 Jan 2006 StarPhoenix, ..."I thought we were starting to gel a bit (Saturday)," said Klassen. ... "I'm not making excuses, but teams gel and that's when it starts coming into view.
Presidents reviews avian flu response16 Jan 2006 Messenger.ge, The government has decreed that the driver of a family car has to pay GEL 3.60, of marshrutka - GEL 4.80, of bus - GEL 9.60, and of cargo vehicles - GEL 12 for ...
Economic Ministry Praised For 200516 Jan 2006 Prime News Agency, According to him, the projected state revenues and financial sources were revised four times and rose by GEL 581 m in total. “Despite ...
GroPep Starts Phase 1 Infertility Trial16 Jan 2006 Medical News Today (press release), The trial, conducted at the CMAX Adelaide-based facilities, involves healthy female volunteers each receiving a single administration of PV903 gel (or placebo ...
Goddards retiringB16 Jan 2006 Barbados Advocate, We are also heartened to pass the baton to someone who has served the company for the last 24 years, Directors said in the GELs annual report for 2005.
Keep Them Guessing ... By Simply Renewing Your Smile16 Jan 2006 PR Newswire (press release), ...you appear younger." How Crest Whitestrips Renewal works is simple: it uses clear, flexible strips coated with a specially-formulated whitening gel to brighten ...
A DOG'S LIFE TO STAY WITH PET16 Jan 2006 Electric New Paper, Star. To bathe him weekly, she buys cleansing gel from Nu Skin, a US cosmetics brand that's usually used by people, not dogs. A ...
Genetic Fingerprint unmasks Microbial Vandals16 Jan 2006 Open PR (press release), In a technique known as denaturing gradient gel electrophoresis, the ITS1 fragments are applied to a gel which is subjected to an electrical charge. ...
FOREX-Dollar on back foot on interest rate worries16 Jan 2006 Reuters.uk, ...expectations of its dwindling rate advantage, some dealers said support for the US currency against the euro and the yen was beginning to gel around current ...
Portsmouth 0, Everton 1 (D,Post)16 Jan 2006 ic Liverpool, ...arrivals - a spending spree which, bankrolled by Russian millionaire Alexandre Gaydamak, is something Moyes can only dream about - gel quickly otherwise they ...
Russia, Germany and Energy Politics16 Jan 2006 theTrumpet.com, Russian President Putin is too shrewd of a political strategist to have not thought this thing through. Something does not quite gel in this whole scenario. ...
Big Monday Preview - UConn at Syracuse16 Jan 2006 SyracuseInsider.com (subscription) ...makings of something special. One thing SU has got going right now is the way the team has started to gel offensively. This is due ...
Marathoners raise $6 million16 Jan 2006 Arizona Republic, ..."But I feel good.". She consumed a power gel pack for energy and some ibuprofen for her legs and a got hug for her morale then got back on the road to Tempe. ...
RESERVE BANK STAFF GIVEN BIRDFLU EMERGENCY BAG16 Jan 2006 TMCnet New Zealand Press Association Via Thomson Dialog NewsEdge)Wellington, Jan 16 NZPA - Reserve Bank staff have been given medical face masks, hand-gel, gloves and ...
Pushing on with caution16 Jan 2006 Woodstock Sentinel Review, We just want to get our game ready for that. "We have our lines set for the last nine games, so it will take a game or two for them to gel," Partlo said. ...
Birds die in Azerbaijan, but bird flu is not confirmed16 Jan 2006 Regnum, Tests have been taken from birds at the Caspian Sea shore, in Ag Gel National Park and other places, Sadagyat Mamedova, Head of the Environment and Natural ...
Ruffled feathers16 Jan 2006 Business Standard, Godrej Consumer Products, for instance, markets its body gel only in international markets, saying India is not yet ready for such products. ...
Flaxseed oil aid to eye problem16 Jan 2006 Belfast Telegraph, Can you suggest anything? A: I would suggest that you apply arnica gel to the affected area 1-2 times a day to help reduce pain and inflammation. ...
For fewer sinus ills, keep your nose clean16 Jan 2006 Evansville Courier & Press (subscription), ...to promote sound nasal health practices, including nasal cleansing with saline sprays or cleansing agents and moisturizing nasal passages with a gel such as AYR ...
Four charged in alleged kidnapping16 Jan 2006 Council Bluffs Daily Nonpareil, ..."We were very fortunate to have things gel the way they did," Anderson said. "Everyone who assisted us was right on the numbers.".
Special delivery: New York slices on ice16 Jan 2006 Allentown Morning Call, Sicilian or round Neapolitan — is baked, heat-sealed in a plastic bag, frozen overnight and shipped in a white pizza box insulated with frozen gel packs and ...
Surprised Bell hoping to cement place in England ODI squad16 Jan 2006 IndiaExpress.com, It’sa difficult place to go and play cricket but we really did work hard on and off the field to make ourselves better cricketers and to start to gel as a ...
[FOUNTAIN]Superego vs. superhold gelJan 15, 2006 International Herald Tribune, The self-love and self-absorption of narcissism originates from a mirror. In Greek mythology, a boy named Narcissus was entranced ...
Pioneer likely secures GEL wrestling titleJan 13, 2006 Daily Democrat, Empire League match. Pioneer would have to lose two matches before the end of the season to miss its third GEL title. They will ...
Warriors Continue To Gel, Maintain LeadJan 12, 2006 Arlington Heights Journal, By ANDY COLE. Maine West's girls basketball team has put a target on its back ... and it couldn't be happier about it. The Warriors ...
Perrigo gets FDA nod for Desoximetasone gelJan 10, 2006 Reuters Jan 10 (Reuters) - Perrigo Co. (PRGO.O: Quote, Profile, Research) on Tuesday said it has received regulatory approval for Desoximetasone Gel USP, 0.05 percent ...
Irish bog man liked to slick back with hair gelJan 10, 2006 Reuters.uk, LONDON (Reuters) - The preserved remains of two prehistoric men discovered in an Irish bog have revealed a couple of surprises -- one used hair gel and the ...
Prehistoric bog man liked to slick back with hair gelJan 10, 2006 ABC Online, The preserved remains of two prehistoric men discovered in an Irish bog have revealed a couple of surprises - one used hair gel and the other stood more than ...
Stock up as anti-AIDS gel fast-trackedJan 9, 2006 Australian, It is a vaginal gel which works as a chemical barrier to protect women from contracting HIV and genital herpes during sexual intercourse. ...
Perrigo Company Announces FDA Approval for Desoximetasone GelJan 10, 2006 PharmaLive.com (press release), Company today announced that it has received approval from the US Food and Drug Administration (FDA) to manufacture and market Desoximetasone Gel USP, 0.05%. ...
FDA fast-tracks anti-HIV and herpes gelJan 11, 2006 United Press International 11 (UPI) -- A vaginal gel that incorporates nanotechnology to prevent the spread of HIV and genital herpes could be commercially available as soon as 2008. ...
FDA fast-tracks anti-HIV and herpes gelJan 11, 2006 Monsters and Critics.com, WASHINGTON, DC, United States (UPI) -- A vaginal gel that incorporates nanotechnology to prevent the spread of HIV and genital herpes could be commercially ...
The gel that relieves Alzheimer's - in menJan 3, 2006 Daily Mail - UK, A gel containing the hormone testosterone could be used to treat the symptoms of Alzheimer's in men, new research suggests. Rubbing ...
Turkish Seiner Fined By GEL 50 000Jan 6, 2006 Prime News Agency, Tbilisi. January 06 (Prime-News) – Turkish seiner detained for violation of shipping rules was fined by GEL 50 000. The Prime-News ...
Stocks On GEL 33 978 Sold At Stock ExchangeJan 5, 2006 Prime News Agency, Tbilisi. January 05 (Prime-News) – Stocks on GEL 33 978 were sold at the stock exchange of Georgia on Thursday. The Prime-News ...
Gel Cartridge KitJan 6, 2006 Bioscience Technology, GCK-RNA QC (Quality Control) gel cartridge kit, for use with the eGene HDA-GT12 Genetic Analyzer, can be used to check the quality of total RNA, poly A RNA ...
NSAID gel curbs pain of knee arthritisDec 22, 2005 Reuters NEW YORK (Reuters Health) - Adults with painful osteoarthritis of the knee may find relief by rubbing on a gel containing the nonsteroidal anti-inflammatory ...
Peplin to ramp up testing of cancer gelDec 28, 2005 The Age, Drug developer Peplin Ltd will ramp up human testing of its proposed fast-action skin cancer gel in coming months after raising $10 million from institutional ...
Lakers Continue to GelDec 16, 2005 Los Angeles Times, Kobe Bryant scored 41 points Friday night to lead the Los Angeles Lakers over the Washington Wizards 97-91. The win was the sixth ...
Cancer gel tests bankrolledDec 29, 2005 Australian, DRUG developer Peplin will ramp up human testing of its proposed fast-acting skin-cancer gel in coming months, after raising $10 million from institutional ...
Gel battery boost for radio tagsDec 20, 2005 BBC News, It is called the Organic Radical Battery (ORB) and is based on a type of plastic that exists in a gel state. The gel allows the ...
New Hair Colour Styling Gel From Inspiration Alan SalonDec 29, 2005 Bru Direct, Bandar Seri Begawan – Anyone could celebrate the New Year in style with the new washable hair colour styling gel front Inspiration Alan Salon. ...
NSAID gel curbs pain of knee arthritisDec 28, 2005 ABC News Adults with painful osteoarthritis of the knee may find relief by rubbing on a gel containing the nonsteroidal anti-inflammatory drug (NSAID) diclofenac (sold ...
Hospital’s fears over 'HIV-bashing' gelDec 26, 2005 This is Local London, HEALTH bosses have expressed concern over a new gel which claims to protect against sexually-transmitted infections (STIs). Sx-Gel ...
Tbilisi City Administration Granted GEL 400 To Aged WomenDec 17, 2005 Prime News Agency, December 17 (Prime-News) – In connection with the ‘Barbaroba’ holiday Tbilisi City Administration granted GEL 400 to two aged women Mariam Maissuradze ...
Gel ‘birds’ to clean up strikesDec 20, 2005 Flight International Gel packs that mimic biological soft tissue, with hard particulates inside to represent bone fragments, could replace dead birds in aerospace impact testing. ...
Three-in-one wash gel has owner groomed for successDec 17, 2005 Stuff.co.nz, ...and market research, thinking. There are two-in-ones, so why not a three-in-one shampoo, body wash and shaving gel? He had a hunch ...
Gel-Coated Coil Keeps Brain Aneurysms At BayDec 21, 2005 NBC 17.com, The problem is it can grow back. To treat Goatley, doctors used a new HydroCoil. It's gel coated and expands, so aneurysms can't grow. ...
Carmine Gotti: Got gel?Dec 26, 2005 Asbury Park Press, Carmine Gotti Agnello, whose fame comes from being the grandson of late Godfather John Gotti, has been popping up in the darndest places. ...
Here comes teeth whitening gel!Dec 15, 2005 Business Standard, ..."The product range is led by a teeth whitening gel - Aquawhite - that has introduced a new category of dental care in the country. ...
Antares late-stage study of gel to start in 2006Dec 13, 2005 Reuters Canada, ...(AIS.A: Quote) on Tuesday said it expects to finish by the end of the year mid-stage clinical trials for its gel to treat overactive bladder syndrome, and ...
Antares Reports Progress with Anturol(TM) Oxybutynin GelDec 13, 2005 Yahoo! News (press release) ...(Amex: AIS - News) announced important progress in the development of Anturol(TM), the Company's lead proprietary oxybutynin ATD(TM) gel product for the ...
Antares Reports Progress with Anturol Oxybutynin GelDec 13, 2005 PharmaLive.com (press release), ...announced important progress in the development of Anturol(TM), the Company's lead proprietary oxybutynin ATD(TM) gel product for the treatment of overactive ...
Honored Teachers To Be Granted GEL 50Dec 13, 2005 Prime News Agency, December 13 (Prime-News) – Tbilisi City administration’s culture and education service will grant honored teachers of Tbilisi GEL 50 till the New Year. ...
FDA accepts Barrier's dermatitis gel for reviewDec 12, 2005 Pharmaceutical Business Review The FDA has accepted Barrier Therapeutics' new drug application for Sebazole, a topical gel for the treatment of seborrheic dermatitis, a disease which causes ...
Irish bog man liked to slick back with hair gelJan 8, 2006 Leading The Charge, LONDON - The preserved remains of two prehistoric men discovered in an Irish bog have revealed a couple of surprises --- one used hair gel and the other stood ...
RepHresh Vaginal Gel Approved in EU for Prevention and Treatment ...Jan 5, 2006 Biotech Intelligence (press release), CEDAR RAPIDS, Iowa, January 5/PRNewswire/ -- RepHresh Vaginal Gel has been approved as a Class IIa medical device for the prevention and treatment of bacterial ...
Mom is still the mom -- even when she's sickJan 14, 2006 Richmond Times Dispatch, ...activities. I've been reminding them to wash their hands, and I make sure to carry an extra bottle of antibacterial gel in my purse. ...
Share your good news: Kristen Orlando promotedJan 8, 2006 Daily News Transcript, AliMed inc., a designer, manufacturer and distributor of ergonomic solutions, has added AliEdge Gel to its selection of workplace safety products. ...
Additional Funds For Bird Flu Prevention In GeorgiaJan 11, 2006 Prime News Agency, January 11 (Prime-News) – The Government of Georgia allocated additional GEL 2,7 for bird flu prevention, Zurab Noghaideli, Georgian Prime Minister said ...
NSAID gel curbs pain of knee arthritisDec 22, 2005 NewKerala.com, NEW YORK: Adults with painful osteoarthritis of the knee may find relief by rubbing on a gel containing the nonsteroidal anti-inflammatory drug (NSAID ...
Makeover 911 : Dealing with post-New Year breakoutsJan 12, 2006 INQ7.net, Deep Clean cleansing gel (not the foaming face wash). For some reasons, this is too strong for most faces; but it is fantastic for ...
Ministry Of Economy Satisfied With 2005Jan 9, 2006 Prime News Agency, According to him, average GDP increase was 8-8,5% (GEL 11 bl). He also added that privatisation revenues stood at GEL 387, state ...
Packaging Firm Invests in New VentureJan 10, 2006 PR Newswire (press release), Under its corporate umbrella, the company operates Gel-Pak of Hayward, CA and Quik-Pak of San Diego, CA. Gel-Pak products are used ...
Antares Reports Progress with Anturol(TM) Oxybutynin GelDec 13, 2005 PR Newswire (press release), ...(Amex: AIS) announced important progress in the development of Anturol(TM), the Company's lead proprietary oxybutynin ATD(TM) gel product for the treatment of ...
Antares late-stage study of gel to start in 2006Dec 13, 2005 Metro Toronto, ...on Tuesday said it expects to finish by the end of the year mid-stage clinical trials for its gel to treat overactive bladder syndrome, and start late-stage ...
Sigma introduces one-step affinity purification columnJan 13, 2006 LabTechnologist.com, ...centrifugation). As the culture is lysed in the column, the target protein is captured on the same highly selective HIS-Select Affinity Gel. ...
Perrigo Gets Drug ApprovalJan 11, 2006 TheStreet.com ...commentary - research - Cramer's Take) said on Tuesday it has received Food and Drug Administration clearance to manufacture and market Desoximetasone Gel 0.05 ...
Innovative solution for flawless legsJan 8, 2006 Malta Independent on Sunday, Venalta Gel by Alta Care Laboratoires – Paris helps improve the general tone and reduces visibility of spider veins, varicose veins and thread veins. ...
A 100-watt smileJan 10, 2006 Indianapolis Star, How it's done: The dentist cleans the teeth with pumice, applies either a protective gel to gums or a rubber shield to protect soft tissues. ...
Mylan Laboratories and Forest Laboratories Announce Nebivolol ...Jan 12, 2006 PharmaLive.com (press release), ...and maintenance treatment of major depressive disorder and for generalized anxiety disorder in adults; Namenda(R) (memantine HCl), an N- methyl-D-aspartate ...
‘Butterfly’ impact crater in Hesperia PlanumJan 5, 2006 Moldova.org, Mars Express spacecraft. The pictures show a large elliptical impact crater in the Hesperia Planum region of Mars. The HRSC obtained ...
Water not widespread on MarsJan 2, 2006 Colorado Daily, The region is known as Meridiani Planum, may have been more geologically similar to volcanic areas such as Yellowstone, Hawaii or Italy. ...
Slashback: Dry Mars, Wet Doc, Keyboard TeaserJan 11, 2006 Slashdot Sensible Clod writes "The Meridiani Planum region on Mars, long believed to have been covered with water millions of years ago, may not have been so wet after ...
MRT editorial for Tuesday, Jan. 3Jan 3, 2006 MyWestTexas.com, Scientists studying the bounty of data from Opportunity now believe that life at Meridiani Planum would have likely had a tough time getting started eons ago. ...
Mars Region Probably Less Watery In Past Than Thought, Says StudyDec 21, 2005 CU Boulder News & Events, Known as Meridiani Planum, the region may have been more geologically similar to volcanic regions in parts of North America, Hawaii or Europe, said Thomas ...
European craft snaps a 16-mile crater on MarsJan 5, 2006 Times Online, The European Space Agency’s Mars Express orbiter took the photographs of the elliptical impact crater, right, as it passed over the Hesperia Planum region of ...
New study challenges Martian water theoryDec 21, 2005 Xinhua, The Meridiani Planum on the red planet had been listed asevidence of widespread, intermittent Martian environment after NASA's Mars rover Opportunity had ...
Scientists Release New Theory on the Red PlanetDec 27, 2005 The Conservative Voice, The Meridiani Planum on the red planet had been listed as evidence of widespread, intermittent Martian environment after NASA's Mars rover had explored the ...
Studies Cast Doubt on Idea of Life on MarsDec 21, 2005 ABC News ...by the Mars Exploration rover Opportunity on March 1, 2004, shows the layered rocks of the "El Capitan" area near the rover's landing site at Meridani Planum. ...
Mars not so wet after all?Jan 4, 2006 Hindu, When Opportunity touched down on a part of Mars called Meridiani Planum, it came across geology that looked tantalisingly like the product of standing water. ...
Mars rovers become astronomical successJan 6, 2006 Chicago Tribune, Spirit landed in Gusev Crater, a 90-mile-wide depression south of the Martian equator. Opportunity landed on Meridiani Planum on the other side of the planet. ...
Red rovers go extra milesJan 1, 2006 Ottawa Sun, Spirit landed in Gusev Crater, a 145-km-wide depression south of the Martian equator. Opportunity touched down on Meridiani Planum. ...
Two for the booksJan 3, 2006 Columbus Dispatch (subscription), It bounced to a stop in an area called the Gusev Crater. Opportunity, which landed Jan. 24, landed in a small crater in the Meridiani Planum. ...
Rovers Still Explore Mars After 2 YearsJan 1, 2006 Leading The Charge, Martian equator. Opportunity followed three weeks later, touching down on Meridiani Planum on the other side of the planet. Three ...
It's not over yet for Mars roversJan 2, 2006 Edmonton Sun, ...south of the Martian equator. Opportunity touched down on Meridiani Planum on the other side of the planet. In two years, Spirit ...
Studies cast doubt on idea of life on MarsDec 21, 2005 San Jose Mercury News, Opportunity touched down on Endurance Crater in the Meridiani Planum region and began examining numerous rocks and minerals for geologic evidence of past water ...
Nasa’s rovers still probing Mars after two yearsDec 31, 2005 Gulf Times, Opportunity, which alit on the Meridiani Planum around Mars’ other side from Spirit on January 24, 2004, has been examining bedrock exposures along a route ...
Mars water theory disputedDec 21, 2005 Rocky Mountain News, ...years ago. Opportunity bounced onto the surface of Meridiani Planum, a vast plain that straddles the planet's equator. Three months ...
SPACE 2006: New Orbiter To Join Mars ClanDec 26, 2005 Discovery Channel On March 10, 2006, a new probe joins the Martian armada. When Spirit and Opportunity touched down in Gusav Crater on Jan. 3, 2003, and Meridiani Planum on Jan. ...
A year of far-out findings in spaceDec 29, 2005 Austin American-Statesman (subscription), Analysis of minerals that Opportunity found in the Endurance Crater suggest the area, known as the Meridiani Planum, was covered with water that was too acidic ...
New Sleeping Pills Are Effective, But None Stands Out As The BestJan 1, 2006 Medical News Today (press release), The drugs are commonly prescribed for insomnia in place of older sedatives such as benzodiazepines (marketed under brands such as Halcion, ProSom and Restoril ...
Can't get to sleep? Drug firms take noteDec 26, 2005 Charlotte Observer, ...alcohol and with a low threshold for overdosing -- and most sleep experts consider them improved over sleep inducers such as Halcion and Restoril that were ...
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