Indication: Used in the treatment of signs and symptoms of benign prostatic hyperplasia.
Pharmacology: Tamsulosin, an alpha-adrenoceptor blocker with enhanced specificity for the alpha-adrenoceptors of the prostate, is commonly used to treat benign prostatic hyperplasia (BPH).
Mechanism Of Action: Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.
Absorption: Absorption of tamsulosin HCI from capsules 0.4 mg is essentially complete (>90%) following oral administration under fasting conditions.
Interactions:
DrugBank: Interactions for Tamsulosin
Interactions for Tamsulosin:
Drug-Drug Interactions: The pharmacokinetic and pharmacodynamic interactions between FLOMAX capsules
and other alpha-adrenergic blocking agents have not been determined. However, interactions may be expected and FLOMAX
capsules should NOT be used in combination with other alpha-adrenergic blocking agents.
The pharmacokinetic interaction between cimetidine and FLOMAX capsules was investigated. The results indicate
significant changes in tamsulosin HCI clearance (26% decrease) and AUC (44% increase). Therefore, FLOMAX capsules
should be used with caution in combination with cimetidine, particularly at doses higher than 0.4 mg.
Results from limited in vitro and in vivo drug-drug interaction studies between tamsulosin HCI and
warfarin are inconclusive. Therefore, caution should be exercised with concomitant administration of warfarin and
FLOMAX capsules.
Chemical IUPAC Name: 5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxy-benzenesulfonamide
Chemical Formula: C20H28N2O5S
Half Life: 5-7 hours
Drug Type: Approved Drug
# Accession No: APRD00036
CAS Registry Number: 106133-20-4
Tamsulosin News (When available)
FLOMAX One-Week Sweepstakes ChallengeDec 15, 2005 CBS 3, ...even more serious,� said Monroe. Click below to learn more about this condition and the FLOMAX one-week sweepstakes challenge.
FDA Cautions Consumers Against Filling US Prescriptions AbroadJan 12, 2006 Community Dispatch (press release) For example, in the United States, "Flomax" is a brand name for tamsulosin, a treatment for an enlarged prostate, while in Italy, the active ingredient in the ...
US warns of brand errors in imported drugsJan 12, 2006 International Herald Tribune, Drugs with identical brand names cited in the FDA warning are: Aldactone, Alphadine, Antagon, Calan, Cervidil, Cloderm, Diasorb, Dilacor, Flomax, Hexalen, Naqua ...
Local doctor credited with a medical inventionDec 31, 2005 Marshalltown Times Republican, In correcting urination problems, Tamsulosin, or Flomax, also paralyzes dilator muscles in the normally firm iris of the eye, making it floppy. ...
On prostate health, Monroe offers pearls of wisdomDec 16, 2005 philly.com, Approximately 50 percent of men between 51 and 60 have some symptoms. In Monroe's case, he was treated with a drug called Flomax. ...
Fitch Affirms Abbott Laboratories 'AA-'; Outlook StableDec 22, 2005 Business Wire (press release), ...from Synthroid and Biaxin generic competition and a co-promotion agreement with Boehringer Ingleheim (BI) for the low-margin Mobic, Flomax, and Micardis ...
Using his legend to educateDec 18, 2005 philly.com, ...that was treatable, and I wanted other people to know about this," said Monroe, who for the last month has been on a media tour called the "Flomax One Week ...
OLD SCHOOL: Earl MonroeDec 18, 2005 Cleveland Plain Dealer, Monroe is trying to champion another cause, this one being the Flomax One Week Challenge, a national campaign to educate men about benign prostatic hyperplasia ...
It’s all in the nameDec 28, 2005 Calcutta Telegraph, A 50-year-old woman, for example, was hospitalised after taking Flomax, used to treat the symptoms of an enlarged prostate, instead of Volmax, used to relieve ...
Mixing meds and supplements could be dangerousDec 28, 2005 Asbury Park Press, ..."And I take glucosamine and chondroitin for my joints, a multivitamin, Vitamin E, and Flomax for my prostate," he said listing the supplements he takes daily. ...
Astellas May Sell Over-the-Counter Drug Unit, People SayDec 14, 2005 Bloomberg 30, Astellas' net income rose 42 percent from a year earlier to 67.3 billion yen on overseas demand for its Harnal prostate treatment and Prograf organ ...
