|
Tadalafil
resources
|
|
|
|
|
|
DRUG INFO
Tadalafil
Drug Name:
Tadalafil
Indication: Used for the treatment of erectile dysfunction
Pharmacology: Tadalafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Tadalafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with Tadalafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, Tadalafil should not cause an erection.
Mechanism Of Action: Tadalafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by Tadalafil enhances erectile function by increasing the amount of cGMP.
Drug Category: Vasoconstrictor Agents; Phosphodiesterase Inhibitors; ATC:G04BE08
Brand Names/Synonyms: CIA; Cialis; Cialis/Tadalafil Hcl; Cialis/Taladafil; IC 351; ICOS 351; Tadalafil; Tadanafil
Dosage Forms: TABLET
Absorption: After single oral-dose administration, the maximum observed plasma concentration (Cmax) of tadalafil is achieved between 30 minutes and 6 hours (median time of 2 hours). Absolute bioavailability of tadalafil following oral dosing has not been determined.
Interactions: Interactions for Tadalafil:
Effects of Other Drugs on Tadalafil
Cytochrome P450 Inhibitors:
Tadalafil is a substrate of and predominantly metabolized by CYP3A4. Studies have shown that drugs that inhibit CYP3A4 can increase tadalafil exposure.
Ketoconazole (400 mg daily), a selective and potent inhibitor of CYP3A4, increased tadalafil 20-mg single-dose exposure (AUC) by 312% and Cmax by 22%, relative to the values for tadalafil 20 mg alone. Ketoconazole (200 mg daily) increased tadalafil 10-mg single-dose exposure (AUC) by 107% and Cmax by 15%, relative to the values for tadalafil 10 mg alone.
HIV Protease inhibitor: Ritonavir (200 mg twice daily), an inhibitor of CYP3A4, CYP2C9, CYP2C19, and CYP2D6, increased tadalafil 20-mg single-dose exposure (AUC) by 124% with no change in Cmax, relative to the values for tadalafil 20 mg alone. Although specific interactions have not been studied, other HIV protease inhibitors would likely increase tadalafil exposure.
Based upon these results, in patients taking concomitant potent CYP3A4 inhibitors, the dose of Tadalafil should not exceed 10 mg, and Tadalafil should not be taken more frequently than once in every 72 hours.
Other cytochrome P450 inhibitors: Although specific interactions have not been studied, other CYP3A4 inhibitors, such as erythromycin, itraconazole, and grapefruit juice, would likely increase tadalafil exposure.
Cytochrome P450 Inducers:
Studies have shown that drugs that induce CYP3A4 can decrease tadalafil exposure.
Rifampin: Rifampin (600 mg daily), a CYP3A4 inducer, reduced tadalafil 10-mg single-dose exposure (AUC) by 88% and Cmax by 46%, relative to the values for tadalafil 10 mg alone. Although specific interactions have not been studied, other CYP3A4 inducers, such as carbamazepine, phenytoin, and phenobarbitol, would likely decrease tadalafil exposure. No dose adjustment is warranted.
Gastrointestinal Drugs:
H2 antagonists: An increase in gastric pH resulting from administration of nizatidine had no significant effect on tadalafil pharmacokinetics.
Antacids: Simultaneous administration of an antacid (magnesium hydroxide/aluminum hydroxide) and tadalafil reduced the apparent rate of absorption of tadalafil without altering exposure (AUC) to tadalafil.
Effects of Tadalafil on Other Drugs:
Drugs Metabolized by Cytochrome P450
Tadalafil is not expected to cause clinically significant inhibition or induction of the clearance of drugs metabolized by cytochrome P450 (CYP) isoforms. Studies have shown that tadalafil does not inhibit or induce P450 isoforms CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP2E1.
CYP1A2 substrate: Tadalafil had no clinically significant effect on the pharmacokinetics of theophylline. When tadalafil was administered to subjects taking theophylline, a small augmentation (3 beats per minute) of the increase in heart rate associated with theophylline was observed.
CYP3A4 substrates: Tadalafil had no clinically significant effect on exposure (AUC) to midazolam or lovastatin.
CYP2C9 substrate: Tadalafil had no clinically significant effect on exposure (AUC) to S-warfarin or R-warfarin, nor did tadalafil affect changes in prothrombin time induced by warfarin.
Alcohol
Alcohol and PDE5 inhibitors, including tadalafil, are mild systemic vasodilators. The interaction of tadalafil with alcohol was evaluated in 3 clinical pharmacology studies. In 2 of these, alcohol was administered at a dose of 0.7 g/kg, which is equivalent to approximately 6 ounces of 80-proof vodka in an 80-kg male, and tadalafil was administered at a dose of 10 mg in 1 study and 20 mg in another. In both these studies, all patients imbibed the entire alcohol dose within 10 minutes of starting. In one of these two studies, blood alcohol levels of 0.08% were confirmed. In these two studies, more patients had clinically significant decreases in blood pressure on the combination of tadalafil and alcohol as compared to alcohol alone. Some subjects reported postural dizziness, and orthostatic hypotension was observed in some subjects. When tadalafil 20 mg was administered with a lower dose of alcohol (0.6 g/kg, which is equivalent to approximately 4 ounces of 80-proof vodka, administered in less than 10 minutes), orthostatic hypotension was not observed, dizziness occurred with similar frequency to alcohol alone, and the hypotensive effects of alcohol were not potentiated. Tadalafil did not affect alcohol plasma concentrations and alcohol did not affect tadalafil plasma concentrations. Both alcohol and Tadalafil, a PDE5 inhibitor, act as mild vasodilators. When mild vasodilators are taken in combination, blood-pressure-lowering effects of each individual compound may be increased. Substantial consumption of alcohol (e.g., 5 units or greater) in combination with Tadalafil can increase the potential for orthostatic signs and symptoms, including increase in heart rate, decrease in standing blood pressure, dizziness, and headache.
Anti-Hypertensives
PDE5 inhibitors, including tadalafil, are mild systemic vasodilators. Clinical pharmacology studies were conducted to assess the effect of tadalafil on the potentiation of the blood-pressure-lowering effects of selected anti-hypertensive medications.
Alpha Blockers
Doxazosin: When tadalafil 20 mg was administered to healthy subjects taking doxazosin (8 mg daily), an alpha[1]-adrenergic blocker, there was significant augmentation of the blood-pressure-lowering effect of doxazosin.
Tamsulosin: In a clinical pharmacology study, when a single dose of tadalafil 20 mg was administered to healthy subjects taking 0.4 mg once-daily tamsulosin, a selective alpha[1A]-adrenergic blocker, no significant decreases in blood pressure were observed. Therefore, based upon significant augmentation of the blood-pressure-lowering effect of doxazosin, an alpha[1]-adrenergic blocker, and no significant effect seen with 0.4 mg once-daily tamsulosin, a selective alpha[1A]-adrenergic blocker, administration of Tadalafil to patients taking any alpha-adrenergic blocker other than 0.4 mg once-daily tamsulosin is contraindicated.
Other Anti-Hypertensive Agents
Amlodipine: A study was conducted to assess the interaction of amlodipine (5 mg daily) and tadalafil 10 mg. There was no effect of tadalafil on amlodipine blood levels and no effect of amlodipine on tadalafil blood levels. The mean reduction in supine systolic/diastolic blood pressure due to tadalafil 10 mg in subjects taking amlodipine was 3/2 mm Hg, compared to placebo. In a similar study using tadalafil 20 mg, there were no clinically significant differences between tadalafil and placebo in subjects taking amlodipine.
Metoprolol: A study was conducted to assess the interaction of sustained-release metoprolol (25 to 200 mg daily) and tadalafil 10 mg. Following dosing, the mean reduction in supine systolic/diastolic blood pressure due to tadalafil 10 mg in subjects taking metoprolol was 5/3 mm Hg, compared to placebo.
Bendrofluazide: A study was conducted to assess the interaction of bendrofluazide (2.5 mg daily) and tadalafil 10 mg. Following dosing, the mean reduction in supine systolic/diastolic blood pressure due to tadalafil 10 mg in subjects taking bendrofluazide was 6/4 mm Hg, compared to placebo.
Enalapril: A study was conducted to assess the interaction of enalapril (10 to 20 mg daily) and tadalafil 10 mg. Following dosing, the mean reduction in supine systolic/diastolic blood pressure due to tadalafil 10 mg in subjects taking enalapril was 4/1 mm Hg, compared to placebo.
Angiotensin II receptor blocker (and other anti-hypertensives): A study was conducted to assess the interaction of angiotensin II receptor blockers and tadalafil 20 mg. Subjects in the study were taking any marketed angiotensin II receptor blocker, either alone, as a component of a combination product, or as part of a multiple anti-hypertensive regimen. Following dosing, ambulatory measurements of blood pressure revealed differences between tadalafil and placebo of 8/4 mm Hg in systolic/diastolic blood pressure.
Aspirin
Tadalafil did not potentiate the increase in bleeding time caused by aspirin.
Chemical IUPAC Name: (6R-trans)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
Chemical Formula: C22H19N3O4
Half Life: 17.5 hours
Drug Type: Approved Drug
# Accession No: APRD00071
CAS Registry Number: 171596-29-5
|
|
|
|
|
|
Tadalafil News
(When available)
Sex and Eugenics in the Twenty-First Century: Huh? 15 Jan 2006
Digital Divide Network, Indeed, on a planet where we have problems feeding everyone, it's hard to defend against Eugenics because we have Viagra and Cialis for people 'past their prime ...
NFL Stiffs Levitra 15 Jan 2006
The Moderate Voice ...the Olympics. As a result, Cialis, which is marketed by ICOS and Eli Lilly & Co., will not be promoted during the Super Bowl. The ...
Last hurrah for Western Open? Jan 14, 2006
Chicago Tribune, By Ed Sherman. This year's Cialis Western Open may mark the final time "Western" is in the title. The PGA Tour confirmed Friday that ...
Cialis Ads Change Focus Jan 11, 2006
Media Buyer Planner, A new ad campaign for impotence drug Cialis begins today, and it's a departure from earlier ads, the New York Times reports. In ...
Cialis and Levitra Could Significantly Challenge Market Leader ... Dec 20, 2005
PR Newswire (press release), ...is dominated by Pfizer's Viagra, the reported efficacy of Bayer/GlaxoSmithKline's Levitra and the longer duration of action of Lilly/Icos's Cialis could enable ...
For Impotence Drugs, Less Wink-Wink Jan 10, 2006
New York Times, By STUART ELLIOTT. THE makers of Cialis, a prescription drug to treat erectile dysfunction, are changing the way they advertise it to consumers. ...
Warning Label on Levitra Jan 12, 2006
LiveArticles.org, FDA approved three drugs for erectile dysfunction are Levitra, Viagra and Cialis. ... Viagra accounts for more cases of blindness than Levitra and Cialis. ...
Levitra: Alternative to Viagra and Cialis Dec 14, 2005
LiveArticles.org, The names of these drugs are Viagra, Cialis and Levitra. ... But other drugs which are giving tough competition to Viagra are Cialis and Levitra. ...
Ads for erectile drug Levitra less racy now Jan 13, 2006
NorthJersey.com, And Eli Lilly, which makes Cialis, the third pill in the erectile dysfunction niche, is using an actual doctor in its new campaign, eschewing attractive actors ...
Makers of drugs for impotence tone down ads Jan 9, 2006
Seattle Post Intelligencer By STUART ELLIOTT. The makers of Cialis, a prescription drug to treat erectile dysfunction, are changing the way they advertise it to consumers. ...
NFL dropping Levitra as a sponsor Jan 10, 2006
Bothell Herald, Changes in guidelines mean drugs, such as ICOS' Cialis, will see less advertising during sporting events. By Eric Fetters. The National ...
NFL ends marketing for erectile dysfunction drugs, saying ads got ... Jan 11, 2006
Pittsburgh Post Gazette, ...with the makers of the anti-impotence drug Levitra out of concern ads promoting the three most popular erectile dysfunction drugs -- Viagra, Cialis and Levitra ...
Super Bowl Forces New Look at Sexy Ads Jan 12, 2006
FOX News Barack Obama, D-Ill., described himself in a statement as “a parent who has had to sit through uncomfortable Cialis commercials while watching television ...
Super Bowl no longer 'right moment' Jan 6, 2006
Indianapolis Business Journal, In a marketing strategy shift, the Indianapolis drugmaker will forgo TV commercials for its erectile dysfunction drug Cialis during the Super Bowl and the ...
Magic pills shut out Jan 10, 2006
San Jose Mercury News, League spokesman Brian McCarthy told the Associated Press the league doesn't want to deal with Levitra, Viagra or Cialis anymore because ``the ads shifted from ...
Sex dysfunction drugs: Nowhere to grow? Jan 5, 2006
CNN ...annual sales. But Viagra sales growth failed to impress in 2005, and its new competitors -- Cialis from Eli Lilly & Co. and Levitra ...
Grave side-effects from sex drug contents in product Jan 10, 2006
Malay Mail, ...‘Tadalafil’, better known as ‘Cialis’, should not be used as an ... ‘Cialis’ is an anti-erectile dysfunction drug that is available by prescription. ...
DemiDose(TM) Pill Splitter Allays Concern Over Dose Accuracy in ... Jan 11, 2006
PR Newswire (press release), By design, DemiDose(TM) specifically splits many of the highest priced brand name prescription pharmaceutical tablets, eg, Cialis(R), Fosamax(R), Levitra(R ...
NFL REVEALS PLAN TO STIFF-ARM LEVITRA AND NOT RE-UP Jan 10, 2006
New York Post, ...yesterday that it does not plan to renew its $6 million-a-year sponsorship deal with Levitra and that it has no interest in signing on with Cialis, Viagra or ...
NFL Nixes ED Sponsors, Not Ads Jan 10, 2006
Broadcasting & Cable (subscription), The NFL says it will no longer accept sponsorships from the erectile dysfunction category--Levitra, Cialis--but that does not mean you won't see adds for those ...
ICOS downgraded to "neutral" Jan 9, 2006
New Ratings Although Cialis has witnessed robust market share gains in 2005, the drug is expected to continue to witness stable sales growth going forward, the analysts say ...
68 year old American arrested for fake Viagra scam Jan 9, 2006
Think Spain, He is thought to have been the leader of a group responsible for selling Viagra, Cialis, Propedio and Erectil tablets, found to be either lacking in active ...
DemiDose(TM) Pill Splitter Allays Concern Over Dose Accuracy in ... Jan 11, 2006
Yahoo! News (press release) By design, DemiDose(TM) specifically splits many of the highest priced brand name prescription pharmaceutical tablets, eg, Cialis®, Fosamax®, Levitra ...
Psychological cure for Impotence Dec 31, 2005
24-7PressRelease.com (press release) Apart from branded medications such as Viagra, Levitra, and Cialis, the generic form of erectile dysfunction drugs are also of immense benefits. ...
Activists push for greater access to emergency contraception Jan 12, 2006
Kentucky.com, It is inequality at its highest.". Added Rep. Mary Lou Marzian, D-Louisville: "I wish you would survey how many of those pharmacies carry Viagra and Cialis. ...
Total recall of Orgacare ordered Jan 11, 2006
Malay Mail, Tadalafil, better known as Cialis, should not be used as an ingredient in traditional medicines, as uncontrolled consumption can be hazardous to health. ...
TRI: Erectile Dysfunction Drug Linked to Throat Problem Jan 13, 2006
MedPage Today, Phosphodiesterase-5 inhibitors (Viagra, Cialis, and Levitra) comprise a relatively new class of drugs, the side effects of which are slowly being recognized. ...
Dream boats, new sex drug and more Jan 5, 2006
MarketWatch Ed Crane reports. Drugs like Viagra, Cialis and others are considered groundbreaking and revolutionary in treating male erectile dysfunction. ...
The People's Pharmacy Jan 1, 2006
Seattle Times, During the past few years, however, I have had some difficulty maintaining an erection. My urologist prescribed Cialis, which works pretty well. ...
NFL, Levitra marketers set to part ways Jan 9, 2006
MSNBC ...drug category has been under pressure because the market is not expanding as analysts and marketers believed it would after Levitra and Cialis, joined Pfizer ...
Warning Label on Levitra Dec 21, 2005
LiveArticles.org, FDA approved three < A href="http://www.levitratalks.com/">drugs for erectile dysfunction are Levitra, Viagra and Cialis. But the ...
Viagra gets RFID Jan 8, 2006
Australian IT, Although it remains one of the company's biggest products, Viagra revenue has slipped amid competition from the longer-acting Cialis treatment sold by Eli ...
Tagliabue's NFL Too Shy For Racy Levitra Ads Jan 9, 2006
Forbes Cialis, pushed by a joint venture of Eli Lilly (nyse: LLY - news - people ) and ICOS (nasdaq: ICOS - news - people ), sponsors various golf tournaments on the ...
Bogus drugs flood the market Jan 11, 2006
Daily Nation (subscription), Although some of its thunder has been stolen by new entrants in the market like Levitra and Cialis, the name Viagra remains synonymous with sex-enhancing ...
PGA TOUR: Notes: Glover's ace a first Jan 8, 2006
noticias.info, Glover hole-in-one was the first eagle of the season. Glover also had a hole-in-one at the 2004 Cialis Western Open (No. 12 in Round 2). ...
BMW to drive off with Western sponsorship Dec 15, 2005
Chicago Tribune, ...sources. The Western has a year remaining on its deal with Cialis. ... sponsor. Cialis currently is in the final year of a three-year deal. ...
Howard Gensler | Pink & Carey Hart tie the knot Jan 9, 2006
Philadelphia Daily News, ...made it all possible. And what about the scientists behind Viagra and Cialis and Levitra? Where were their prizes? Although many of ...
UPDATE: Levitra, NFL End Sponsorship Pact Jan 9, 2006
Business Online, He noted that partnering with Levitra, or its rivals including Lilly's(LLY)Cialis and Pfizer's(PFE)Viagra may be a bit more controversial than say, a soft ...
The Flip Side Jan 11, 2006
Baltimore Sun, The NFL won't be replacing Levitra with Cialis or Viagra because it is dropping erectile-dysfunction drugs as a sponsorship category. ...
Sex in the golden years: Yes, seniors, the dangers are real Jan 10, 2006
Naples Daily News (subscription), Viagra, Cialis and Levitra, which are designed to help men with erectile dysfunction, had combined global sales of about $2.5 billion in 2004, according to the ...
Hazardous slimming products banned Jan 10, 2006
Sun2Surf, ...erectile dysfunction. (Sildenafil and tadalafil are ingredients in impotency drugs Viagra and Cialis, respectively). "The public ...
Clip and save this: There'll be a quiz later Jan 8, 2006
Los Angeles Daily News, John von Stade, the vice president of a company that handles sponsorship deals for Cialis, told the Sports Business Journal: "There's a real flattening out in ...
Impotence: is it a sign of heart disease? Jan 9, 2006
Times Online, Even more remarkable is the difference that the advent of Viagra, Cialis and Levitra have made to both the understanding and treatment of impotence.
Employees, keep mum on beliefs Dec 16, 2005
Cincinnati Enquirer, ...etc. Men can kiss their Viagra and Cialis goodbye, too. But it won't stop there. Forget about getting a beer at your local pub. ...
Viagra Medicare coverage passes House Dec 14, 2005
United Press International 14 (UPI) -- A House bill that preserves Medicare/Medicaid coverage for impotence drugs like Viagra and Cialis narrowly passed a floor vote Wednesday. ...
Viagra's on the way to India, but there's stiff competition Dec 21, 2005
Australian, Viagra's dominance has since been eroded by drugs such as Eli Lilly & Co's Cialis, the active ingredient of which is tadalafil. ...
Counting on the Viagra brand in India Dec 21, 2005
International Herald Tribune, Pfizer. But Viagra's dominance has since been eroded by drugs like Eli Lilly's Cialis, the active ingredient of which is tadalafil. ...
Avoid the Boulevard of Broken Biotechs Jan 6, 2006
Motley Fool ICOS saw three of its four main drugs in 1997 ultimately fail, but the success of Cialis has meant that long-term investors still have some profits to show for ...
Anti-impotence drug by S.Korea's Dong-A aims for US Dec 30, 2005
Malaysia Star, ..."With Viagra's four hours, you might feel a little rushed, and with Cialis' 36 hours, the effect goes on a bit too long," she said. ...
Freedom of speech getting very expensive Dec 16, 2005
Chicago Tribune, He should rest up, take it easy, play some golf. 10 BMW could replace Cialis as sponsor of the Western Open golf tournament in 2007. ...
Richards Jan 4, 2006
Chicago Sun-Times, An upgraded spam filter will be no better match in 2006 for the purveyors of porn, marketers of mortgages and sellers of Cialis. ...
NEWS SNAP:Bayer Healthcare Fills Its Pipeline -2 Jan 5, 2006
Business Online, ...million. Here Bayer competes with Pfizer Inc.'s (PFE) Viagra and Eli Lilly & Co.'s (LLY) Cialis treatments and ranks behind those two. ...
2006 MERCEDES CHAMPIONSHIPS INTERVIEWS: Jim Furyk Jan 5, 2006
noticias.info, I know that was a disappointment. Bounced back this year with a great win at the Cialis Western Open. Talk about being back here. ...
Flying with the leader Jan 1, 2006
Bothell Herald, ...biotech firms in the state to ever make money, thanks to its joint venture with Eli Lilly & Co., which produces and markets the erectile-dysfunction drug Cialis ...
[FOCUS]Korea must invent new mousetraps Jan 6, 2006
Joongang Ilbo, ...the development and approval by Korean drug regulators of a new treatment for male erectile dysfunction, a market now dominated by Viagra, Levitra and Cialis. ...
Europe on guard against bogus internet Tamiflu Dec 21, 2005
Reuters.uk, ...throws up scores of sites advertising generic Tamiflu, alongside drugs purporting to be copycat versions of impotence treatments Viagra and Cialis, as well as ...
Pfizer eyes 15 percent of Indian market with Viagra Dec 21, 2005
Webindia123, Rs.463 each and the 100-mg pill Rs.594 rupees, on par with prices in other Asian countries, but several times the price of generic alternatives like Cialis. ...
Beyond Viagra: the Cupid chemicals Dec 22, 2005
Kansas City Star, Their experimental chemistry follows the trail of the male-centered miracles of Viagra, Cialis and Levitra that stimulate genital blood flow — a class of ...
Data Show Cost-Effectiveness of NitroMed's BiDil Through Reduced ... Dec 13, 2005
PharmaLive.com (press release), Augmentation of the vasodilatory effects of isosorbide dinitrate by phosphodiesterase inhibitors (eg, Viagra(R)/Revatio(TM), Levitra(R), Cialis(R)) could ...
Accountability welcome Dec 15, 2005
NorthJersey.com, That's a big victory for women - and for fairness. After all, almost all of these plans cover Viagra and Cialis, the top-selling male impotence drugs. ...
(PRN) - United Heritage Corporation Announces the Completion of ... Dec 20, 2005
Bolsamania.com, ...[+]. (PRN) - Cialis and Levitra Could Significantly Challenge Market Leader Viagra for Treatment of Erectile Dysfunction ... [+. ...
Male Sexual Problem Dec 16, 2005
LiveArticles.org, ...drugs. The FDA has approved three oral medicines for the treatments of erectile dysfunction such as Levitra , Cialis and Viagra. ...
Consumers Urged to Seek the VIPPS Seal When Buying Prescription ... Dec 22, 2005
TMCnet ...for access to hard-to-find medications such as Tamiflu or for better prices on drugs not covered by insurance or Medicare such as Viagra(R), Cialis(R) and ...
ICOS to Participate in Upcoming Investment Conference Dec 27, 2005
Business Wire (press release), ...patients. Through Lilly ICOS LLC, ICOS is marketing its first product, Cialis(R) (tadalafil), for the treatment of erectile dysfunction. ...
Diet Pills Popular Among Celebrities Dec 23, 2005
LiveArticles.org, ...to provide visitors with complete information on weight loss, men's health, sexual health, and online prescription drugs like Cialis, Phentermine, Tamiflu ...
Arkansas Sportsman : Hot Springs picks a winner to carry its name Dec 15, 2005
Arkansas Democrat-Gazette (subscription), ...sponsors. Now, you see anglers, boats and tournaments sponsored by an array of sponsors, such as Cialis, Purolator and Land O’Lakes. ...
Pharmaceutical firms vie for new drugs Dec 25, 2005
Korea Herald (subscription), The world's fourth pill for treating erectile dysfunction, Zydena competes against Pfizer's Viagra, Bayer and GlaxoSmithKline's Levitra and Lilly's Cialis. ...
Motorsport: Grey power in driving seat for bit of nostalgia Dec 23, 2005
New Zealand Herald, The players may not be relying on Viagra and Cialis for their drives, but the advertisers recognise the importance of the grey market. ...
Caution tempers hopes for biotech Dec 27, 2005
Seattle Times, ...stocks. Icos' joint venture with Eli Lilly reached profitability in the third quarter on sales of erectile-dysfunction drug Cialis. ...
What I've Learned: BB King Dec 16, 2005
Smartmoney.com ...your lapel. I have an excellent medical team. There's Dr. Viagra, Dr. Cialis, and nurse Levitra. They keep me, er, straight. The ...
PGA's Furyk to host Exelon Invitational Dec 22, 2005
Norristown Times Herald, The West Chester native, who placed fourth on the money list in 2005 and notched his 10th career Tour win at the Cialis Western Open in July, is involved with ...
Health Providers May Not Pay For Viagra For Cancer Patients Dec 21, 2005
NBC4.TV, ...attitude. Every company is different, Hensel reported, so, if you need Viagra, Cialis or Levitra, check the policy ahead of time. ...
Boomers Get Attention Dec 27, 2005
Hartford Courant, ...is at least 50. Thanks to pharmaceutical companies, Viagra and Cialis are pop culture buzzwords. Cosmetic companies recently hired ...
NAACP and NitroMed Announce Partnership to Narrow Disparities in ... Dec 14, 2005
NAACP (press release), Augmentation of the vasodilatory effects of isosorbide dinitrate by phosphodiesterase inhibitors (eg, Viagra® /RevatioT, Levitra®, Cialis®) could result in ...
Lawmakers agree to fund Viagra use for another year Dec 13, 2005
Malaysia Star, 1, 2006, the start of fiscal 2007, according to congressional aides. Other erectile dysfunction drugs include Cialis, sold by Eli Lilly & Co. ...
Eli Lilly ups manufacturing capacity for 2006 Dec 14, 2005
In-PharmaTechnologist.com, They have also expanded into new markets with their strongest therapies such as its recent submissions of Byetta in Europe for type 2 diabetes, Cialis in Japan ...
Assembly OKs birth control benefit bill Dec 13, 2005
NorthJersey.com, Support for the birth control bill gained momentum in recent years with the advent of male impotence drugs such as Viagra and Cialis, which are covered under ...
Mumbai not so hard on Viagra Dec 20, 2005
Mid-Day Mumbai, Says Jayprakash Mehta, manager of Milind Medical Stores, Malad, “Doctors promote drugs with tadanafil, which cause lesser side-effects than drugs containing ...
|
|
|
