Sulfanilamide resources


DRUG INFO
Sulfanilamide

Drug Name: Sulfanilamide

Indication: For the treatment if vaginitis and vulvovaginitis



Pharmacology: Sulfanilamide is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Mechanism Of Action: Sulfanilamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

Drug Category: Anti-bacterial Agents; Homeopathic Agents; ATC:J01EB06

Brand Names/Synonyms: 1162 F; A-349; AVC; Albexan; Albosal; Ambeside; Antistrept; Astreptine; Astrocid; Avc; Bacteramid; Bactesid; Collomide; Colsulanyde; Copticide; Deseptyl; Desseptyl; Dipron; Ergaseptine; Erysipan; Estreptocida; Exoseptoplix; F 1162; Fourneau 1162; Gerison; Gombardol; HSDB 223; Infepan; Lusil; Lysococcine; NSC 7618; Neococcyl; Orgaseptine; P-Aminobenzenesulfamide; P-Aminobenzenesulfonamide; P-Aminobenzenesulfonylamide; P-Aminobenzensulfonamide; P-Aminophenylsulfonamide; P-Anilinesulfonamide; P-Sulfamidoaniline; P-Sulfamoylaniline; PABS; Prontalbin; Prontosil Album; Prontosil I; Prontosil White; Prontylin; Pronzin Album; Proseptal; Proseptine; Proseptol; Pysococcine; Rubiazol A; Sanamid; Septamide Album; Septanilam; Septinal; Septolix; Septoplex; Septoplix; Solfanilamide [Dcit]; Stopton Album; Stramid; Strepamide; Strepsan; Streptagol; Streptamid; Streptamin; Streptasol; Streptocid; Streptocid Album; Streptocide; Streptocide White; Streptocidum; Streptoclase; Streptocom; Streptol; Strepton; Streptopan; Streptosil; Streptozol; Streptozone; Streptrocide; Sulfamidyl; Sulfamine; Sulfana; Sulfanalone; Sulfanidyl; Sulfanil; Sulfanilamide; Sulfanilamide Vaginal Cream; Sulfanilimidic Acid; Sulfocidin; Sulfocidine; Sulfonamide; Sulfonamide P; Sulfonylamide; Sulphanilamide; Sulphanilamide Extra Pure; Sulphanilamide Gr; Sulphonamide; Therapol; Tolder; White Streptocide

Dosage Forms: LIQUID; PELLET; TABLET

Absorption: Not Available

Interactions: DrugBank: Interactions for Sulfanilamide

Interactions for Sulfanilamide:

This medicine is generally safe with other medications, but patient should consult doctor or pharmacist if patient is taking a blood thinner (anticoagulant), cyclosporin, phenytoin, or methotrexate.



Chemical IUPAC Name: 4-aminobenzenesulfonamide

Chemical Formula: C6H8N2O2S

Half Life: Not Available

Drug Type: Approved Drug

# Accession No: APRD00438

CAS Registry Number: 63-74-1



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