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Sulfametopyrazine
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DRUG INFO
Sulfametopyrazine
Drug Name:
Sulfametopyrazine
Indication: For the treatment of urinary tract infection and chronic bronchitis
Pharmacology: Sulfametopyrazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Mechanism Of Action: Sulfametopyrazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Drug Category: Antimalarials; Anti-Infectives; Anti-Infective Agents, Urinary
Brand Names/Synonyms: AS 18908; Dalysep; F.I. 5978; FI 5978; Farmitalia 204/122; Kelfizin; Kelfizina; Kelfizine; Kelfizine W; Longum; Polycidal; SMP; SMP2; Solfametopirazina [Dcit]; Sulfalen; Sulfalene; Sulfalene [Usan:Inn]; Sulfaleno [Inn-Spanish]; Sulfalenum [Inn-Latin]; Sulfamethopyrazine; Sulfamethoxypyrazine; Sulfamethoxysuccinate; Sulfametopyrazine; Sulfametoxypyridazin; Sulfapyrazinemethoxine; Sulfapyrazinemethoxyine; Sulfapyrazinemethoxyne; WR 4629
Dosage Forms: Tablet
Absorption: Not Available
Interactions: Drug Interactions:
Sulfametopyrazine increases the effects of the some drugs, including:
ACETOHEXAMIDE
CHLORPROPAMIDE
CLOZAPINE
GLIBENCLAMIDE
GLIBORNURIDE
GLICLAZIDE
GLIMEPIRIDE
GLIPIZIDE
GLIQUIDONE
GLYMIDINE
TOLAZAMIDE
TOLBUTAMIDE
Sulfametopyrazine decreases the effects of the follwing drugs:
ETHINYLESTRADIOL
ORAL CONTRACEPTIVES
POTASSIUM AMINOBENZOATE
Chemical IUPAC Name: 4-amino-N-(3-methoxypyrazin-2-yl)-benzenesulfonamide
Chemical Formula: C11H12N4O3S
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00517
CAS Registry Number: 152-47-6
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Sulfametopyrazine News
(When available)
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NewKerala.com, There are different varieties of pepper such as Betal pepper (Piper betle), Indian long pepper (Piper longum), Java long pepper (Piper retrofractum), Rough ...
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