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Sulfadiazine
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DRUG INFO
Sulfadiazine
Drug Name:
Sulfadiazine
Indication: For the treatment of rheumatic fever and meningococcal meningitis
Pharmacology: Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Mechanism Of Action: Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Drug Category: Antiprotozoals; Anti-Infectives; Anti-Infectives; ATC:D06BA01; ATC:J01EC02
Brand Names/Synonyms: A-306; Adiazin; Adiazine; Coco-Diazine; Cocodiazine; Codiazine; Cremodiazine; Cremotres; Debenal; Deltazina; Diazin; Diazolone; Diazovit; Diazyl; Eskadiazine; Honey Diazine; Lantrisul; Lipo-Diazine; Lipo-Levazine; Liquadiazine; Metha-Meridiazine; Microsulfon; Neazine; Neotrizine; Palatrize; Pecta-Diazine, Suspension; Piridisir; Pirimal; Pyrimal; Quadetts; Quadramoid; RP 2616; S. N. 112; SDA; Sanodiazine; Sildaflo; Silvadene; Spofadrizine; Ssd; Sterazine; Sulfa-Triple #2; Sulfacombin; Sulfadiazene; Sulfadiazin; Sulfadiazine; Sulfaloid; Sulfanilamidopyrimidine; Sulfapirimidin; Sulfapyrimidin; Sulfapyrimidine; Sulfatryl; Sulfazin; Sulfazine; Sulfolex; Sulfonamides Duplex; Sulfonsol; Sulfose; Sulphadiazine; Terfonyl; Theradiazine; Thermazene; Tri-Sulfameth; Trifonamide; Triple Sulfa; Triple Sulfas; Triple Sulfoid; Trisem; Trisulfapyrimidine, Oral Suspension; Truozine
Dosage Forms: CREAM
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: 4-amino-N-pyrimidin-2-yl-benzenesulfonamide
Chemical Formula: C10H10N4O2S
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00190
CAS Registry Number: 68-35-9
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Sulfadiazine News
(When available)
Weight-loss drug isn't for everyone Jan 15, 2006
Miami Herald, Meridia, available by prescription, is intended for people who need to lose 30 or more pounds. It makes them feel full, a signal to stop eating. ...
Pills can help win weight-loss fight Jan 10, 2006
Contra Costa Times, Meridia, on the market since 1997, curbs appetite. Xenical has been around for six years. It contributes to weight loss by inhibiting fat absorption. ...
Arena shares gain from results of weight-loss drug Dec 15, 2005
San Diego Union Tribune, If approved, Arena's drug would face competition from existing medicines such as Roche's Xenical and Abbott Laboratories' Meridia, both of which have side ...
Appetite Suppressants, The Big Hope, The Big Letdown Jan 5, 2006
NewsBlaze (press release), ...stroke. Sibutramine (Meridia) was approved for weight- loss treatment in 1998, just in time to fill the void left by Fen-Phen. Not ...
Glaxo's Weight-Loss Wait Dec 15, 2005
Motley Fool ...had worldwide sales of $496.6 million -- a disappointing level for a veteran product with only one competitor, the appetite suppressant Meridia from Abbott ...
Consumer Reports Examines Weaknesses of Current Drug-safety System Dec 27, 2005
Kansas City infoZine, Mefloquine (Lariam) to prevent malaria; Rosuvastatin (Crestor) for high cholesterol; Salmeterol* (Serevent) for asthma; Sibutramine (Meridia) for weight loss ...
America's Weight Problem - Where Is The Pharmaceutical Industry? Dec 19, 2005
Medical News Today (press release), Meridia® (sibutramine hydrochloride monohydrate) from Knoll Pharmaceuticals, one of two weight loss Rx drugs that have been approved by the Food and Drug ...
Whiny Whistleblower of the Year Award Dec 30, 2005
American Council on Science and Health, ...bans. Graham has made a career out of calling for the banning of drugs, including Accutane, Arava, Meridia, Serevent, and Bextra. ...
Rimonabant adds appetizing choice to slim obesity market Dec 30, 2005
Nature.com (subscription), The drugs on the market—Abbott's Meridia (sibutramine, marketed as Reductil in Europe) and Roche's Xenical (orlistat)—offer ho-hum effectiveness and side ...
The Skinny on Obesity Drugs Dec 22, 2005
Motley Fool As a serotonin 5-HT2C receptor agonist, APD356 is attempting to suppress appetite by essentially the same means employed by Abbott Labs' Meridia and the ...
Gut Reaction Dec 14, 2005
Smartmoney.com Currently, there are only two obesity drugs on the market: Meridia by Abbott Laboratories (ABT) and Xenical by Switzerland's Roche. ...
Wear PJs to library for stories Dec 13, 2005
Daily News Journal (subscription), ...stops will include the Roscoe Brown parking lot, Kurcher Court, Tombee Court, Headwater Court, Berkshire subdivision's pool, Apostle Lane, Meridia Court and ...
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