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Succinylcholine
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DRUG INFO
Succinylcholine
Drug Name:
Succinylcholine
Indication: Used in surgical procedures where a rapid onset and brief duration of muscle relaxation is needed (includes intubation, endoscopies, and ECT)
Pharmacology: Succinylcholine is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Succinylcholine is a depolarizing skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. This depolarization may be observed as fasciculations. Subsequent neuromuscular transmission is inhibited so long as adequate concentration of succinylcholine remains at the receptor site. Succinylcholine has no direct action on the uterus or other smooth muscle structures.
Mechanism Of Action: The mechanism of action of Succinylcholine involves what appears to be a "persistent" depolarization of the neuromuscular junction. This depolarization is caused by Succinylcholine mimicking the effect of acetylcholine but without being rapidly hydrolysed by acetylcholinesterase. This depolarization leads to desensitization.
Drug Category: Neuromuscular Depolarizing Agents; Skeletal Muscle Relaxants; ATC:M03BX
Brand Names/Synonyms: Anectine; Quelicin; Quelicin Preservative Free; Succinylcholine; Succinylcholine Chloride; Sucostrin
Dosage Forms: LIQUID
Absorption: Not Available
Interactions:
DrugBank: Interactions for Succinylcholine
Interactions for Succinylcholine:
Drugs which may enhance the neuromuscular blocking action of succinylcholine include: promazine,
oxytocin, aprotinin, certain non-penicillin antibiotics, quinidine, b-adrenergic blockers,
procainamide, lidocaine, trimethaphan, lithium carbonate, magnesium salts, quinine, chloroquine, diethylether,
isoflurane, desflurane, metoclopramide, and terbutaline. The neuromuscular blocking effect of succinylcholine may be
enhanced by drugs that reduce plasma cholinesterase activity (e.g., chronically administered oral contraceptives,
glucocorticoids, or certain monoamine oxidase inhibitors) or by drugs that irreversibly inhibit plasma
cholinesterase.
If other neuromuscular blocking agents are to be used during the same procedure, the possibility of a
synergistic or antagonistic effect should be considered.
Chemical IUPAC Name: trimethyl-[2-[3-(2-trimethylammonioethoxycarbonyl)propanoyloxy]ethyl]ammonium
Chemical Formula: C14H30N2O4
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00159
CAS Registry Number: 306-40-1
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Succinylcholine News
(When available)
Vagn Flyger, biologist with squirrel expertise Jan 14, 2006
San Jose Mercury News, Using a new tranquilizing dart gun, Mr. Flyger aided research of large animals by zapping them with succinylcholine chloride, a surgical muscle relaxant. ...
Squirrel migration, polar bear expert Jan 13, 2006
Charlotte Observer, Using a new tranquilizing dart gun, Flyger had successes in aiding research of large animals by zapping them with succinylcholine chloride, a surgical muscle ...
The issue: Is it humane? Dec 28, 2005
North Platte Telegraph, ...anesthesia. The Humane Society International Web site lists succinylcholine chloride as an "inhumane method" of euthanasia. North ...
The issue: Is it humane? Dec 28, 2005
North Platte Telegraph, ...choice. The shelter uses a drug called Sucostrin for the procedure. ... method. Heinzle said he never used Sucostrin in his practice. ...
Euthanasia drug dropped Dec 29, 2005
North Platte Telegraph, The shelter has been using a paralytic drug, Sucostrin, which stopped the animals from breathing, but left them conscious as they died. ...
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