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Streptozocin
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DRUG INFO
Streptozocin
Drug Name:
Streptozocin
Indication: For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma)
Pharmacology: Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine. Streptozocin is indicated in the treatment of metastatic islet cell carcinoma of the pancreas. Streptozocin inhibits DNA synthesis in bacterial and mammalian cells. In bacterial cells, a specific interaction with cytosine moieties leads to degradation of DNA. The biochemical mechanism leading to mammalian cell death has not been definitely established; streptozocin inhibits cell proliferation at a considerably lower level than that needed to inhibit precursor incorporation into DNA or to inhibit several of the enzymes involved in DNA synthesis. Although streptozocin inhibits the progression of cells into mitosis, no specific phase of the cell cycle is particularly sensitive to its lethal effects.
Mechanism Of Action: Although its mechanism of action is not completely clear, streptozocin is known to inhibit DNA synthesis, interfere with biochemical reactions of NAD and NADH, and inhibit some enzymes involved in gluconeogenesis. Its activity appears to occur as a result of formation of methylcarbonium ions, which alkylate or bind with many intracellular molecular structures including nucleic acids. Its cytotoxic action is probably due to cross-linking of strands of DNA, resulting in inhibition of DNA synthesis.
Drug Category: Antibiotics; Antineoplastic Agents; ATC:L01AD04
Brand Names/Synonyms: Rcra Waste Number U206; STREPTOZOTOCIN; STRZ; STZ; Streptozocin; Streptozocin [Usan:Inn]; Streptozocine [Inn-French]; Streptozocinium [Latin]; Streptozocinum [Inn-Latin]; Streptozoticin; Streptozotocin; U 9889; U-9889; Zanosar
Dosage Forms: POWDER FOR SOLUTION
Absorption: Poor oral absorption (17-25%)
Interactions:
DrugBank: Interactions for Streptozocin
Interactions for Streptozocin:
ZANOSAR may demonstrate additive toxicity when used in combination with other cytotoxic drugs.
Streptozocin has been reported to prolong the elimination half-life of doxorubicin and may lead to severe bone marrow
suppression; a reduction of the doxorubicin dosage should be considered in patients receiving ZANOSAR concurrently.
The concurrent use of strep-tozocin and phenytoin has been reported in one case to result in reduced streptozocin
cytotoxicity.
Chemical IUPAC Name: 1-methyl-1-nitroso-3-[2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]-urea
Chemical Formula: C8H15N3O7
Half Life: 5-15 minutes
Drug Type: Approved Drug
# Accession No: APRD00209
CAS Registry Number: 18883-66-4
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Streptozocin News
(When available)
Meat preservatives implicated in New Zealand's diabetes crisis Jan 8, 2006
Newstarget.com, He gave tiny doses of a drug called streptozotocin to mice who were genetically prone to developing type 1 diabetes and to another group who were not prone. ...
Renal effects of a neutralising RAGE-antibody in long-term ... Dec 21, 2005
Journal of Endocrinology ...role for RAGE in renal changes in type 1 diabetes, we examined the renal effects of a neutralising murine RAGE-antibody (ab) in streptozotocin (STZ)-diabetic ...
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