Somatropin recombinant resources


DRUG INFO
Somatropin recombinant

Drug Name: Somatropin recombinant

Indication: For treatment of dwarfism, acromegaly and prevention of HIV-induced weight loss



Pharmacology: Used in the treatment of dwarfism and growth failure, growth hormone (hGH) stimulates skeletal growth in pediatric patients with growth failure due to a lack of adequate secretion of endogenous GH. Skeletal growth is accomplished at the epiphyseal plates at the ends of a growing bone. Growth and metabolism of epiphyseal plate cells are directly stimulated by GH and one of its mediators, IGF-I (insulin-like growth factor).

Mechanism Of Action: hGH binds to the human growth hormone receptor (GHR). Upon binding, hGH causes dimerization of GHR, activation of the GHR-associated JAK2 tyrosine kinase, and tyrosyl phosphorylation of both JAK2 and GHR. These events recruit and/or activate a variety of signaling molecules, including MAP kinases, insulin receptor substrates, phosphatidylinositol 3' phosphate kinase, diacylglycerol, protein kinase C, intracellular calcium, and Stat transcription factors. These signaling molecules contribute to the GH-induced changes in enzymatic activity, transport function, and gene expression that ultimately culminate in changes in growth and metabolism.

Drug Category: Anabolic Agents; Hormone replacement; pituitary (68:28.00)

Brand Names/Synonyms: Somatotropin precursor;Growth hormone;GH;GH-N;Pituitary growth hormone;Growth hormone 1; BioTropin (Biotech General); Genotropin (Pharmacia; Pfizer); Humatrope (Eli Lilly); Tev-Tropin (GATE); Nutropin (Genentech Inc.); NutropinAQ (Genentech Inc.); Protropin (Genentech Inc.); Norditropin (Novo Nordisk); Saizen (Serono SA); Serostim (Serono SA)

Dosage Forms: LIQUID;POWDER FOR SOLUTION

Absorption: Not Available

Interactions: Not Available



Chemical IUPAC Name: Human growth hormone

Chemical Formula: C990H1532N262O300S7

Half Life: Not Available

Drug Type: Approved Drug

# Accession No: BIOD00086

CAS Registry Number: 12629-01-5



Somatropin recombinant News
(When available)


The perils of whistleblowing  Jan 6, 2006
In-PharmaTechnologist.com, Dr Rost accused Pfizer/Pharmacia of defrauding the Medicare Program by off-label promotion of Genotropin, a prescription growth hormone. ...

Ex-Pfizer VP named 2005's "Whiny Whistleblower"  Jan 10, 2006
Spero News Dr. Eric Topol, the Cleveland Clinic," Rost said, adding "I’m only saddened that Dr. Ross failed to mention that under my leadership Genotropin became the #1 ...

Fired executive Rost sues Pfizer  Dec 14, 2005
Pharma Times (subscription), ...he brought against the company, alleging that Pfizer's Pharmacia unit had inappropriately marketed its human growth hormone product Genotropin (somatropin) for ...

Fired drug-industry critic sues Pfizer  Dec 13, 2005
Newark Star Ledger, ...dismissal was in retaliation for his efforts to bring attention to allegedly illegal marketing tactics to promote the "off- label" use of Genotropin, a human ...

Whistle-Blower Sues Pfizer  Dec 13, 2005
New York Times, Recently unsealed documents showed that Mr. Rost filed a lawsuit in June 2003, asserting that Genotropin, a human growth hormone, was being promoted illegally.

Pfizer gains on increase to dividend  Dec 13, 2005
Providence Journal (subscription), And on another front, former Pfizer vice president Peter Rost, who was fired after suing the drugmaker for promoting unauthorized uses for Genotropin, a growth ...

Whiny Whistleblower of the Year Award  Dec 30, 2005
American Council on Science and Health, ...investigation of his own company in 2003, alleging that Pfizer was responsible for the improper marketing of the synthetic growth hormone Genotropin (which had ...

Terminated Pfizer Exec Files Lawsuit against Pfizer  Dec 13, 2005
Yahoo! News (press release) ...and, thereafter, another Pharmacia employee who had raised issues of illegality regarding the marketing, selling and distribution of Genotropin, a prescription ...

Former Pfizer Exec Files Another Lawsuit  Dec 13, 2005
Brandweek Magazine, However, one of Rost's first acts was to inform Pfizer that the Pharmacia human growth hormone business, and its main brand, Genotropin, was riddled with legal ...

Fired Pfizer Official Rost Sues Company, Alleging Improper ...  Dec 14, 2005
Kaiser network.org, Rost's lawsuit alleged that Pharmacia, which Pfizer acquired in 2003, engaged in inappropriate sales and marketing of the growth hormone Genotropin before the ...

Business news in brief  Dec 14, 2005
Philadelphia Inquirer, Rost said in a June 2003 complaint that Pharmacia marketed the human growth hormone Genotropin for unapproved, or "off-label," uses, and improperly sought ...

Business Digest  Dec 14, 2005
Baltimore Sun, Rost charged in a June 2003 complaint that Pharmacia marketed the human growth hormone Genotropin for unapproved uses and improperly sought reimbursement from ...

Nautilus Moves its Long-Lasting, High Availability Human Growth ...  Jan 9, 2006
PR Newswire UK (press release), ...today that it has successfully completed pharmacokinetics and therapeutic efficacy animal studies on its long-lasting human growth hormone (hGH), Vitatropin(TM ...

Can growth hormone reverse the aging process?  Jan 10, 2006
Standard-Speaker, Jan. 10: NBC's Robert Bazell reports on the push of human growth hormone (hGH) on consumers as the modern-day fountain of youth. ...

Can growth hormone reverse the aging process?  Jan 8, 2006
MSNBC By Judith Reichman, MD. Is human growth hormone (hGH), the long sought after fountain of youth? Dr. Judith Reichman was invited on ...

Is Growth Hormone Replacement Illegal in Deficient Adults?  Dec 21, 2005
PR Newswire (press release), ...firm of Collins, McDonald & Gann, PC (http://www.cmgesq.com), recently presented a lecture entitled "Legal Update 2005: Prescribing Growth Hormone for Adult ...

Novo Nordisk Introduces New Storage Flexibility for Norditropin(R)  Jan 11, 2006
Yahoo! News (press release) ...announced that Norditropin NordiFlex® (somatropin [rDNA origin] injection) 5 mg and 10 mg, the only prefilled, multi-dose, disposable growth hormone pen, can ...

Serono Completes Second Phase III Trial of its Proprietary ...  Jan 8, 2006
Yahoo! News (press release) NYSE: SRA) announced today the completion of its pivotal Phase III double-blind, placebo-controlled trial of Serono's recombinant human growth hormone in the ...

Foreign Drugs May Have Same Name as US Product but Different ...  Jan 12, 2006
SeniorJournal.com, Taking a different active ingredient may not help, and may even harm, the user, warns the FDA. Jan. 10, 2006 - Can growth hormone reverse the aging process? ...

Novo Nordisk Introduces New Storage Flexibility for Norditropin(R)  Jan 11, 2006
PR Newswire (press release), New FDA approved growth hormone storage guidelines and expanded product line provide flexibility, choice and convenience PRINCETON, NJ, Jan. ...

Krabbe's former coach caught in drugs net again  Jan 14, 2006
Scotland on Sunday, As part of the current criminal investigation, a raid on Springstein and Breuer's house produced a haul of drugs including Andriol, growth hormone and insulin ...

Lilly, Alkermes Partner on Osteoporosis Treatment  Jan 9, 2006
Inside INdiana Business (press release), In 2000, Lilly and Alkermes partnered on an inhaled form of a human growth hormone and in 2001, the companies agreed to develop an inhaled insulin system. ...

Alkermes and Lilly Announce Agreement for the Development and ...  Jan 9, 2006
Genetic Engineering News, ...parathyroid hormone provides an opportunity to leverage the experience we have gained from our inhaled insulin and human growth hormone collaborations," stated ...

US Federal District Court in Indianapolis Rules in Emisphere's ...  Jan 9, 2006
Yahoo! News (press release) ...confidential know-how outside of the licensed field of PTH (including use of Emisphere's technology with insulins, human growth hormone, interferon follicle ...

HARPER'S INDEX  Jan 15, 2006
Fort Worth Star Telegram, ...other than sex. 2: Average height gain, in inches, of adolescents who use human growth hormone over five and a half years. 8: Age ...

Time to stage a better kudocast  Jan 15, 2006
Variety (subscription) ...unheeded, despite the fact that 99% of viewers don't recognize the name of a publicist at PMK/HBH, which to the untrained ear sounds like a human growth hormone ...

Newspaper Publisher Turns Cheese Maker  Jan 14, 2006
Houston Chronicle, ...of it," Miller said. "They mixed it with a growth hormone that wouldn't occur in nature, and they found listeria.". Miller says he ...

Commenting on amino acids  Jan 10, 2006
The South African Journal of Natural Medicine (subscription), As we age the levels of growth hormone in tissues decline. Lowered levels of growth hormone are considered to be related to ageing changes seen in people. ...

Why do some people gain weight when others don’t?  Dec 15, 2005
U of M News Service (press release), It turned out that animals with high levels of growth hormone were resistant to gaining weight. Horowitz returned to his study data ...

Hopkins Researcher Links Gene Mutation With Poor Outcomes In ...  Jan 9, 2006
Science Daily (press release) For Common Kind Of Dwarfism (January 11, 2001) -- A common type of dwarfism may not be principally caused by a defect in the human growth hormone gene, as ...

Salmon That Grow Up Fast  Jan 10, 2006
BusinessWeek In normal salmon, the gene that controls the production of growth hormone is activated by light, so the fish generally grow only during the sunny summer months ...

Serono completes phase 3 trial of r-hGH drug for HIV-linked ...  Jan 8, 2006
Forbes GENEVA (AFX) - Serono said it has completed its second phase III double-blind, placebo-controlled trial of its recombinant human growth hormone (r-hGH) to ...

Tercica Launches Increlex in the US; Only Drug Approved for the ...  Jan 3, 2006
Genetic Engineering News, ...patients throughout the US, represents the first major innovation in treating children with short stature since recombinant human growth hormone was approved ...

The perils of whistleblowing  Jan 6, 2006
In-PharmaTechnologist.com, Dr Rost accused Pfizer/Pharmacia of defrauding the Medicare Program by off-label promotion of Genotropin, a prescription growth hormone. ...

Theratechnologies Comments on Stock Activity  Jan 9, 2006
CCNMatthews (press release), ...specified primary and major secondary endpoints in its pivotal Phase 3 double-blind, placebo-controlled trial of its recombinant human growth hormone in the ...

Antares Pharma Submits Additional Listing Application With The ...  Jan 11, 2006
PharmaLive.com (press release), ...injector system is distributed in more than 30 countries for the administration of insulin and is marketed for use with human growth hormone through licensees ...

Is local the new organic?  Jan 12, 2006
Grist Magazine, Even though it's not organic, there's no growth hormone used and I am supporting the last of the independent dairy farms in my state, Washington. ...

Tranzyme Pharma Receives IND Clearance for its Novel Ghrelin ...  Jan 10, 2006
Genetic Engineering News, Importantly, concurrent studies in rats have demonstrated that TZP-101 does not elicit growth hormone release at gastroprokinetic doses, in contrast to other ...

5 Doping Scandal Predictions for 2006  Jan 2, 2006
NewsReleaseWire.com (press release) ...tremors, tennis players will use mild anabolics such as decadurabolin or oxandrolone, in addition to track favorites such as modafinil and growth hormone (GH). ...

Lilly, partner to develop inhalable Forteo  Jan 10, 2006
Indianapolis Star, The two developed an inhaled insulin, now in late-phase testing, and an inhalable human growth hormone, which is in early-phase testing. ...

Theratechnologies says 18% stock hike may be due to Serono SA ...  Jan 9, 2006
Canada.com, ...because Theratechnologies is presently recruiting patients in a Phase 3 clinical trial for a similar indication testing its growth hormone releasing factor ...

Worse Than Being Bald  Jan 12, 2006
CBS News Too bad he felt like hair would really make a difference in his life because getting banned from the Olympics for using a hair growth hormone is clearly worse ...

(PRN) - Roche and Amira Pharmaceuticals Announce Innovative ...  Jan 8, 2006
Bolsamania.com, ...(PRN) - Serono Completes Second Phase III Trial of its Proprietary Recombinant Human Growth Hormone for HIV-Associated Adipose Redistribution Syndrome (HARS ...

Emisphere Technologies Presentation at the 24th Annual JPMorgan ...  Jan 10, 2006
Yahoo! News (press release) ...and its partners have advanced oral formulations or prototypes of salmon calcitonin, heparin, insulin, parathyroid hormone, human growth hormone and cromolyn ...

Genentech Announces Full Year and Fourth Quarter 2005 Results  Jan 10, 2006
MSN Money US sales of legacy products in 2005, including growth hormone, cardiovascular products and Pulmozyme(R) (dornase alfa, recombinant) Inhalation Solution ...

LAB International common shares eligible for coverage under Quebec ...  Jan 10, 2006
Canada NewsWire (press release), ...powder inhaler platform. Its pipeline also includes therapeutics for asthma, COPD, and growth hormone deficiencies. LAB Research ...

Buna man gains national attention after doctors discover a rare ...  Jan 5, 2006
KBTV4.tv, ...“His particular type of tumor had the genetic code tell it to produce a certain hormone called growth hormone�, Dr. Joseph Zwrischenberger said during a ...

Doctor’s Research Gets Top Honor At National Conference  Dec 28, 2005
Westchester.com, ...of children with growth disorders in the US, specifically, NCGS collects data on patients being treated with Nutropin, a growth hormone, which Genentech ...

Breast cancer drug helps height?  Dec 17, 2005
myDNA.com, Each boy took tamoxifen pills twice a day for six months to two years. Six of the boys also received regular doses of growth hormone. ...

2005: A Year of Success for Plant and Animal Biotechnology  Jan 4, 2006
PR Newswire (press release), Scientists estimate that just 15 of these Jersey cows could produce enough human growth hormone to meet the current world demand for the hormone. ...

European Indexes Up at Midday  Jan 9, 2006
BusinessWeek Serono (SRA )(+1.45%) climbed as its recombinant human growth hormone achieved primary and secondary endpoints in a Phase III trial to treat an HIV-related ...

Genentech Announces Full Year and Fourth Quarter 2005 Results  Jan 10, 2006
Yahoo! News (press release) US sales of legacy products in 2005, including growth hormone, cardiovascular products and Pulmozyme® (dornase alfa, recombinant) Inhalation Solution ...

Alkermes, Eli Lilly enter new drug pact  Jan 9, 2006
BusinessWeek ...filings. Alkermes and Lilly are already collaborating on a form of inhalable insulin and a form of inhalable human growth hormone. ...

Earnings Watch Updates, advisories and surprises  Jan 11, 2006
MarketWatch ...due to exocrine pancreatic insufficiency, and ALTU-238, which is a Phase II clinical trial in adults for the treatment of growth hormone deficiency. ...

(PRN) - Quest Diagnostics to Speak at the 24th Annual JPMorgan ...  Jan 9, 2006
Bolsamania.com, ...[+]. (PRN) - Nautilus Moves its Long-Lasting, High Availability Human Growth Hormone Into Formal Preclinical Development ... [+.

Ambrx to Present at the 24th Annual JPMorgan Healthcare Conference  Jan 10, 2006
PR Newswire (press release), ...and peptides. Ambrx's most advanced product candidate, ARX-201, is a patent-protected, long-acting human growth hormone. In preclinical ...

A roundup of editorial opinion from Michigan newspapers  Jan 9, 2006
Flint Journal, US medical professionals for such use, but the drug caught on in the bodybuilding community because it was thought to enhance the production of growth hormone. ...

Ghrelin stimulates phagocytosis and superoxide production in fish ...  Jan 11, 2006
Journal of Endocrinology ...kidney. Gene expression of growth hormone (GH) secretagogue-receptor (GHS-R) was detected by RT-PCR in leucocytes. Pretreatment ...

Sleep Better Tonight - Look Your Best Tomorrow  Dec 19, 2005
Christian Post, Take glutamine before bed. Taking 2000 mg to 3000 mg of glutamine before bed encourages the release of growth hormone. Growth ...

68 year old American arrested for fake Viagra scam  Jan 9, 2006
Think Spain, Christmas skiing holiday in the Swiss Alps. The man is also sought by the FBI for the illegal distribution of a growth hormone.

Holding on to hope  Jan 10, 2006
Black Hills Pioneer, Shirleen added later that Charlie could even give himself his own growth hormone shots. "It's painful to watch your child knowing you can't do anything. ...

Experts trying to push lifespans even higher  Jan 11, 2006
Asbury Park Press, ...version of the Fountain of Youth. Then human growth hormone was touted as a cure for old age. "Nothing discovered yet has been shown ...

Sports and Substance Abuse  Jan 10, 2006
Medscape (subscription) ...direct testosterone analogues used in the 1930s to the use of more modern, sophisticated hormones like synthetic erythropoietin and human growth hormone (HGH). ...

Biogenerics Could Now Enter the EU Market in a Matter of Months ...  Jan 3, 2006
Business Wire (press release), 2006. In the US immediate progress depends on the FDA's use of the controversial 505(b)(2) pathway for insulin and growth hormone. ...

Billie Jean King and Novo Nordisk Offer Scholarships to Young ...  Jan 8, 2006
PR Web (press release), In addition, Novo Nordisk has a leading position within areas such as hemostasis management, growth hormone therapy, and hormone therapy for women.

Doctor offered cheating tips  Dec 16, 2005
Myrtle Beach Sun News, ...and Shortt could "keep levels adjusted.". use of a "medium amount of growth hormone.". Short transcripts of taped interviews with ...

Sapphire Therapeutics, Inc. Builds Drug Development Team Through ...  Jan 9, 2006
dBusinessNews Newark (press release), ...products. While at Merck, he co-chaired the growth hormone secretagogue project team with Sapphire founder Dr. Roy G. Smith. With ...

10 trends in technical barriers to trade  Dec 27, 2005
China Economic Net, One of the most representative cases in international trade is Beef Hormone Dispute between EU and the US for beef containing growth hormone, which might bring ...

UPDATE 2-Insmed says FDA approves Iplex for growth failure  Dec 12, 2005
Reuters ...is entitled to seven years of marketing exclusivity for the treatment of children with severe primary IGF-1 deficiency or with growth hormone gene deletion who ...

Court transcripts detail Walls' in-depth talk with doctor about ...  Dec 14, 2005
San Jose Mercury News, ...declined comment. Shortt has pleaded not guilty to all 43 counts of illegally distributing steroids and human growth hormone. Sources ...

Palmeiro's plight part of biggest story in 2005 - steroids  Jan 5, 2006
San Jose Mercury News, ...them pass the tests.". Certainly there are ways to do so. Baseball still does not test for human growth hormone. Use of insulin-like ...

Small plants loom large  Jan 2, 2006
Checkbiotech.org (press release), ...described in the Nature article directs the plant to make a protein, dubbed DWF1 (for "Dwarf 1"), that is involved in the production of a plant growth hormone. ...

CEO Sets Sights on Building Shareholder Value at Theratechnologies ...  Dec 15, 2005
Business Wire (press release), THG213.29 in acute renal failure, TH9507 in cystic fibrosis and TH9507 in adult growth hormone deficiency are projects that meet the value-creation criteria. ...

Supplementing teenagers?  Dec 17, 2005
Malaysia Star, The growth hormone which regulated growth in childhood is supplemented with sex hormones which initiate the adolescent growth spurt. ...

US analysts: Good year expected for Teva  Jan 2, 2006
Ynetnews, ...in neurological drugs and notes the drug maker is well-prepared for the potential surge of so-called generic biologic drugs, such as growth hormone and anemia ...

(PZ) Novo Nordisk Receives Subpoena  Dec 20, 2005
Houston Chronicle, In addition, Novo Nordisk has a leading position within areas such as haemostasis management, growth hormone therapy and hormone replacement therapy. ...

Accused French considered suicide  Jan 5, 2006
Australian, French's life was turned upside down in December 2003 when a cleaner found a bucket filled with new and used syringes, equine growth hormone, steroids and ...

Generic-Drug Makers Face a Big Year  Jan 3, 2006
Los Angeles Times, ...drugs, and she notes that the drug maker is prepared for the potential surge of so-called generic biologic drugs, such as growth hormone and anemia treatments. ...

America's Weight Problem - Where Is The Pharmaceutical Industry?  Dec 19, 2005
Medical News Today (press release), ...carboxypeptidase inhibitors, adipocyte 11B-hydroxysteroid dehydrogenase type 1, amylase inhibitors, synthetic human growth hormone, corticotrophin-releasing ...

How Shortt coached NFL players to cheat  Dec 16, 2005
Charlotte Observer, Shortt also told Walls he “could do with a little bit of growth hormone,� which Carson said is used to build muscle mass but hasn’t been shown to have ...

Biotech company closes after running out of cash  Jan 2, 2006
Checkbiotech.org (press release), ...than using genetically engineered bacteria or animal cells, which is the usual method of producing pharmaceutical proteins like insulin and growth hormone. ...

New Study Results Validate Tight Blood Sugar Control  Jan 3, 2006
Yahoo! News (press release) ...specialized training enables them to be experts in the care of endocrine diseases, such as diabetes, thyroid disorders, growth hormone deficiency, osteoporosis ...

Sapphire Therapeutics, Inc.'s Oral Ghrelin Mimetic Shows Potential ...  Dec 15, 2005
Genetic Engineering News, Ghrelin is a small endogenous protein that acts on the Growth Hormone Secretagogue Receptor (GHSR), recognized as a key control point in the growth hormone ...

Longtime administrator leaves dairy commission  Jan 6, 2006
Capital Press (subscription), He leaves an industry facing a controversy over the use of the growth hormone bovine somatotropin and confusion over the health benefits of milk consumption. ...

Confessions of a Fake Journalist 2005: The Year in Satire  Dec 30, 2005
Portsmouth Herald News, The document also alleged that on at least three separate occasions in 2003 Mr. Claus consumed egg nog laced with the Human Growth Hormone. ...

Steroid sighns in fighters  Jan 3, 2006
SaddoBoxing.com ...clue look at Roys cheek bones he used steroids to after he left the middle weight division and for his fight with john ruiz he probaly took human growth hormone ...

Guide to the events of 2006  Jan 4, 2006
Morgan County Citizen, ...hospital’s Love Light Tree, and overnight the tree will grow seven feet (it will later be revealed that the fertilizers contains TGH, or tree growth hormone ...

Former Pfizer Exec Files Another Lawsuit  Dec 13, 2005
Brandweek Magazine, Protection Act, among other claims, after he disclosed to Pfizer that a company it was acquiring, Pharmacia, had been marketing human growth hormone illegally. ...

International Medical Officer  Dec 30, 2005
Dagens Medicin, ...our goal of being the best in our markets and making a signifi cant difference to people within the areas of diabetes, growth hormone therapy, haemostasis ...

SPORTS AND DRUGS Montgomery says he's done  Dec 15, 2005
San Francisco Chronicle, He also denied ever admitting to the BALCO grand jury his use of either "the clear" or human growth hormone. But in reality, during Montgomery's Nov. ...

Athletics: 'Criminal conspiracy' of world sprint king  Dec 13, 2005
Independent, ...later, Conte also accused her of doping abuse, telling the ABC television news programme 20/20 that she had administered herself with human growth hormone in a ...

Grist: The Investment Trap  Dec 16, 2005
Inc.com, Yet R&D spending continues to surge. Innovation is our economy's growth hormone, and all businesses spend an increasing amount of energy in its pursuit. ...

Stimulation of pancreatic b-cell replication by incretins involves ...  Dec 19, 2005
Journal of Endocrinology ...cyclase activator, forskolin, at 10 nM (~90% increase) and was additive (~170-250% increase) with the growth response to human growth hormone (hGH), indicating ...

NEWSMAKER - Doping probe ruins career of "lucky man" Montgomery  Dec 13, 2005
Reuters India, The US Anti-Doping Agency had accused Montgomery of taking a cocktail of banned performance-enhancing drugs plus human growth hormone as early as 2000. ...

FDA Approves Insmed's Orphan Drug, Iplex (mecasermin rinfabate ...  Dec 13, 2005
DG News ...rDNA origin) injection) for the treatment of growth failure in children with severe primary IGF-1 deficiency (Primary IGFD) or with growth hormone (GH) gene ...

CEO Sets Sights on Building Shareholder Value at Theratechnologies ...  Dec 15, 2005
PharmaLive.com (press release), By applying the same value-creation criteria, we have now identified cystic fibrosis and adult growth hormone deficiency as other potential areas for ...

FDA Approvals: iPlex, Cethrin, Brivaracetam  Dec 14, 2005
Medscape (subscription) ...the treatment of growth failure in children with severe primary insulin-like growth factor-1 (IGF-1) deficiency (primary IGFD) or with growth hormone (GH) gene ...

Sprinter Says Ban Is End of His Career  Dec 14, 2005
Los Angeles Times, Chronicle reported in June that Montgomery told a grand jury investigating the BALCO scandal that Conte gave him regular doses of human growth hormone and THG ...

Family with a mission  Dec 18, 2005
Los Angeles Daily News, ...the Byers said. Joshua receives a growth hormone shot every day. He will likely require the shots through age 18. Joshua has dental ...

Plant study could assist in cancer treatment  Dec 20, 2005
Indianapolis Star, Researchers have discovered for the first time that proteins similar to multi-drug-resistant proteins in humans move a plant growth hormone into cells, said ...

Disorder leads to compulsive eating  Dec 20, 2005
The News Journal, Growth hormone has been used in Prader-Willi patients over the last five to seven years to increase their growth rate and help them put on lean muscle mass ...

Update 1: Sprinter Tim Montgomery Calls It Quits  Dec 15, 2005
Forbes Montgomery, however, testified that in 2001 Conte gave him weekly doses of human growth hormone and the "clear," the San Francisco Chronicle reported in June ...

Athletics: Shamed sprint king quits  Dec 15, 2005
New Zealand Herald, San Francisco Chronicle last year reported that Montgomery told the grand jury that Balco founder Victor Conte gave him weekly doses of growth hormone and a ...

Alba Therapeutics Announces Upcoming Trials in Celiac Disease and ...  Dec 23, 2005
PR Newswire (press release), Group VP of Lilly Research Labs and was directly involved in the discovery and development of several Lilly drugs, including Humulin(R), Humatrope(R), Evista(R ...

Alba Therapeutics Announces Upcoming Trials in Celiac Disease and ...  Dec 23, 2005
Yahoo! News (press release) VP of Lilly Research Labs and was directly involved in the discovery and development of several Lilly drugs, including Humulin®, Humatrope®, Evista®, Xigris ...

Novo Nordisk Introduces New Storage Flexibility for Norditropin(R)  Jan 11, 2006
Yahoo! News (press release) 11 /PRNewswire-FirstCall/ -- Novo Nordisk today announced that Norditropin NordiFlex® (somatropin [rDNA origin] injection) 5 mg and 10 mg, the only prefilled ...

Novo Nordisk Introduces New Storage Flexibility for Norditropin  Jan 11, 2006
PharmaLive.com (press release), PRINCETON, NJ, January 11, 2006 /PRNewswire-FirstCall/ -- Novo Nordisk today announced that Norditropin NordiFlex(R) (somatropin [rDNA origin] injection) 5 mg ...

Novo Nordisk Introduces New Storage Flexibility for Norditropin  Jan 11, 2006
DG News PRINCETON, NJ -- January 11, 2006 -- Novo Nordisk today announced that Norditropin NordiFlex(R) (somatropin [rDNA origin] injection) 5 mg and 10 mg, the only ...

(PRN) - Webcast Alert: Sovereign Bancorp, Inc. Announces 4Q 2005 ...  Jan 11, 2006
Bolsamania.com, Partnership With the World Golf Championships ... [+. PRN) - Novo Nordisk Introduces New Storage Flexibility for Norditropin(R) ... [.

Genentech Announces Full Year and Fourth Quarter 2005 Results  Jan 10, 2006
MSN Money Months Ended December 31, 2005 2004 Net US Product Sales Rituxan $484,404 $429,184 Herceptin 250,069 125,952 Avastin 359,110 190,546 Nutropin products 94,891 ...

Genentech Announces Vice President Appointments in Commercial ...  Jan 9, 2006
Yahoo! News (press release) In this role, Oswald will be responsible for sales and marketing for four distinct operating groups: Lucentis, Lytics, Nutropin and Pulmozyme. ...

Doctor’s Research Gets Top Honor At National Conference  Dec 28, 2005
Westchester.com, ...largest observational database of children with growth disorders in the US, specifically, NCGS collects data on patients being treated with Nutropin, a growth ...

Genentech/Biogen Idec: wearing the drug marketing suit well?  Jan 12, 2006
Pharmaceutical Business Review For example, in 1999, Genentech paid a $50 million fine related to improper marketing of Protropin (somatrem) and, in October 2004, received a federal subpoena ...

Dead kangaroos don’t bounce, do they?  Jan 14, 2006
Business Online, ...development. The company markets eight recombinant products – Rebif, Gonal-f, Saizen, Serostim, Ovidrel, Luveris, Zorbtive and Raptiva. ...

Serono Completes Second Phase III Trial of its Proprietary ...  Jan 8, 2006
Yahoo! News (press release) The Company has eight biotechnology products, Rebif®, Gonal-f®, Luveris®, Ovidrel® /Ovitrelle®, Serostim®, Saizen®, Zorbtive(TM) and Raptiva®. ...

Serono Completes Second Phase III Trial of its Proprietary ...  Jan 8, 2006
PR Newswire (press release), The Company has eight biotechnology products, Rebif(R), Gonal-f(R), Luveris(R), Ovidrel(R) /Ovitrelle(R), Serostim(R), Saizen(R), Zorbtive(TM) and Raptiva(R ...

Md. Nets $262 Million In Medicaid Settlement  Jan 10, 2006
WBAL Channel.com, ...to 41 others and Washington, DC, has settled in a $262 million agreement over claims against Serono SA, a Swiss corporation that manufactures Serostim, a drug ...

Serono Study Outcome Good, Stock Expensive  Jan 9, 2006
New Ratings 0946 GMT [Dow Jones] Serono (SRA) announces positive results of phase III trial on its drug Serostim in the treatment of HIV-associated adipose redistribution ...

AG Lautenschlager: Announces Wisconsin to Receive $24,899 in ...  Dec 25, 2005
Democratic Party of Wisconsin (press release) State of Wisconsin’s Medicaid program will receive a total of $24,899.70 to address Serono’s unlawful conduct in marketing Serostim,� Lautenschlager said ...

The Siren Song of Serono  Jan 13, 2006
TheStreet.com Legally, Serono is best known for its October settlement of a US government investigation into the marketing of Serostim, a treatment for AIDS wasting. ...

Dead kangaroos don’t bounce, do they?  Jan 14, 2006
Business Online, ...development. The company markets eight recombinant products – Rebif, Gonal-f, Saizen, Serostim, Ovidrel, Luveris, Zorbtive and Raptiva. ...

AG Joins Feds, States To Collect Damages For False Marketing Of ...  Dec 29, 2005
East Texas Review, ...a settlement involving criminal and civil penalties of $704 million paid by a Swiss company for its misleading promotion and marketing of the drug Serostim. ...

Swiss drug firm guilty in AIDS drug case  Dec 28, 2005
Monsters and Critics.com, Geneva-based Serono Laboratories made Serostim, a once-popular anti-wasting drug sold to doctors treating AIDS patients. But as ...

Texas receives $3.6M in settlement over AIDS drug  Dec 27, 2005
San Antonio Business Journal, ...(NYSE:SRA) for illegally promoting and marketing the AIDS drug Serostim. The state of Texas and the Medicaid program received almost ...

Settlement will boost state Medicaid funds by $3 million  Dec 28, 2005
TheNewsTribune.com (subscription), 15 to illegally marketing its AIDS wasting drug, Serostim. ... Despite the settlement, Serostim will remain available through Medicaid. ...

Ohio to share in AIDS drug settlement  Dec 28, 2005
Columbus Business First, ...guilty Dec. 15 to falsifying data on the effectiveness of Serostim, a drug intended to slow weight loss in AIDS patients. The company ...

Texas AG: Texas share nearly $3.6 million  Dec 27, 2005
Team 4 News, Greg Abbott. Abbott says the matter involves misleading promotion and marketing of the drug Serostim (SEHR'-uhs-tihm). Serono Laboratories ...

Abbott says Texas to share nearly $3.6 million  Dec 27, 2005
Denton Record Chronicle (subscription), Abbott. He said the matter involves misleading promotion and marketing of the drug Serostim. Serono Laboratories pleaded guilty Dec. ...

Serono changes tack  Jan 9, 2006
Nature.com (subscription), ...its cash pile was slashed by around $700 million, due to the settlement of a Medicaid fraud case related to its AIDS wasting drug Serostim (somatropin), in the ...

Serono Completes Second Phase III Trial of its Proprietary ...  Jan 8, 2006
Yahoo! News (press release) The Company has eight biotechnology products, Rebif®, Gonal-f®, Luveris®, Ovidrel® /Ovitrelle®, Serostim®, Saizen®, Zorbtive(TM) and Raptiva®. ...

Serono Completes Second Phase III Trial of its Proprietary ...  Jan 8, 2006
PR Newswire (press release), The Company has eight biotechnology products, Rebif(R), Gonal-f(R), Luveris(R), Ovidrel(R) /Ovitrelle(R), Serostim(R), Saizen(R), Zorbtive(TM) and Raptiva(R ...

Other News To Note  Dec 20, 2005
TMCnet ...has formally concluded the previously announced settlement of the government investigation into commercial practices related to Serostim (somatropin [rDNA ...

Eli Lilly fined for selling drug for off-label uses  Dec 21, 2005
The State, In October of this year, Serono SA agreed to pay $704 million for its improper promotion and marketing of an AIDS-wasting drug called Serostim.


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