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Salmeterol
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DRUG INFO
Salmeterol
Drug Name:
Salmeterol
Indication: For the treatment of Asthma and chronic obstructive pulmonary disease (COPD).
Pharmacology: Salmeterol, a highly selective beta(2)-agonist, is used to treat asthma and to prevent bronchospasm in patients with reversible obstructive airway disease.
Mechanism Of Action: Salmeterol's long, lipophilic side chain binds to exosites near beta(2)-receptors in the lungs and on bronchiolar smooth muscle, allowing the active portion of the molecule to remain at the receptor site, continually binding and releasing. Beta(2)-receptor stimulation in the lung causes relaxation of bronchial smooth muscle, bronchodilation, and increased bronchial airflow.
Drug Category: Bronchodilator Agents; Sympathomimetic; Adrenergic beta-Agonists;
Brand Names/Synonyms: Aeromax; Arial; Astmerole; CHEMBANK1801; SEREVENT; Salmetedur; Salmeterol; Salmeterol Xinafoate; Salmeterol [Usan:Ban:Inn]; Salmeterolum [Latin]; Serevent; [Usan:Ban:Inn]
Dosage Forms: METERED-DOSE (AEROSOL); POWDER
Absorption: Because of the small therapeutic dose, systemic levels of salmeterol are low or undetectable after inhalation of recommended doses (50 mcg of salmeterol inhalation powder twice daily). Following chronic administration of an inhaled dose of 50 mcg of salmeterol inhalation powder twice daily, salmeterol was detected in plasma within 5 to 45 minutes in 7 patients with asthma; plasma concentrations were very low, with mean peak concentrations of 167 pg/mL at 20 minutes and no accumulation with repeated doses.
Interactions: [an error occurred while processing this directive]
Chemical IUPAC Name: 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]-phenol
Chemical Formula: C25H37NO4
Half Life: 5.5 hours
Drug Type: Approved Drug
# Accession No: APRD00277
CAS Registry Number: 89365-50-4
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Salmeterol News
(When available)
Serevent May Pose Greater Risk of Death to Blacks Jan 13, 2006
Newsinferno.com, Recently released information about a safety trial on the asthma drug Serevent indicates that blacks who took the drug were four times as likely to have life ...
Roundup: Diet May Reverse Diabetes; Serevent Poses Danger To Some ... Jan 10, 2006
NBC 10.com, The drug is Serevent, and a study by the maker of the drug found a small but significant increase in respiratory- and asthma-related deaths among African ...
Drug Warning For African Americans: Serevent Jan 10, 2006
KSDK, A study by the maker of the drug Serevent found a small, but significant, increase in respiratory and asthma related deaths among African American patients. ...
Asthma Drug May Be Deadlier for Blacks Jan 12, 2006
WebMD Jan. 12, 2006 -- Serevent, a widely prescribed inhaled asthma treatment, may pose a special risk to blacks. Newly released details ...
AstraZeneca's Symbicort gives asthma patients the power to get ... Jan 13, 2006
Pharmaceutical Business Review However, recent labeling changes proposed by the FDA to three asthma drugs (Advair/Seretide, Foradil, and Serevent) have significant implications for the ...
Common Asthma Medication Poses Risk to Black Patients Jan 11, 2006
Forbes More commonly known by its brand name, Serevent, the drug is a member of the beta agonist class of asthma medications, which treat asthma symptoms by relaxing ...
Common Asthma Medication Poses Risk to Black Patients Jan 11, 2006
HealthCentral.com More commonly known by its brand name, Serevent, the drug is a member of the beta agonist class of asthma medications, which treat asthma symptoms by relaxing ...
Study: Drug Puts Some Asthma Patients At Risk Jan 10, 2006
WBAL Channel.com, The manufacturer of the drug Serevent found a small, but significant increase in respiratory and asthma-related deaths among black patients. ...
People's Pharmacy: Asthma drugs require caution Jan 7, 2006
Bryan College Station Eagle, Several months ago an expert panel considered whether the asthma drugs Advair, Foradil and Serevent also should be withdrawn from the market. ...
New Symbicort dose a boon for AstraZeneca? Jan 11, 2006
Monsters and Critics.com, DataMonitor said FDA`s recent proposed labeling changes for other asthma drugs, including Advair/Seretide, Foradil and Serevent, could affect Symbicort if it ...
Consumer Reports Examines Weaknesses of Current Drug-safety System Dec 27, 2005
Kansas City infoZine, Depo-Provera), a contraceptive; Mefloquine (Lariam) to prevent malaria; Rosuvastatin (Crestor) for high cholesterol; Salmeterol* (Serevent) for asthma ...
Health News Dec 20, 2005
Hampton Union, ...qualify. If you take Flovent, Combivent, Proventil, Advair, Pulmicort, Serevent, Atrovent or any other inhaler, the program may help. ...
Whiny Whistleblower of the Year Award Dec 30, 2005
American Council on Science and Health, ...bans. Graham has made a career out of calling for the banning of drugs, including Accutane, Arava, Meridia, Serevent, and Bextra. ...
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