Indication: For the treatment of Type II diabetes mellitus
Pharmacology: Rosiglitazone, a member of the drug group known as the thiazolidinediones or "insulin sensitizers", is not chemically or functionally related to the alpha-glucosidase inhibitors, the biguanides, or the sulfonylureas. Rosiglitazone targets insulin resistance and, hence, is used alone or with metformine or sulfonylurea to improve glycemic control in patients with type 2 diabetes mellitus.
Mechanism Of Action: Rosiglitazone acts as an agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In this way, rosiglitazone enhances tissue sensitivity to insulin.
Drug Category: Vasodilator Agents; Hypoglycemic Agents; Fibrinolytic Agents; Thazolidinediones; ATC:A10BG02
Brand Names/Synonyms: Avandia; Rosigliazone Maleate; Rosiglitazone; Rosiglitazone Maleate; Rosiglitazone and Its Intermediates; Rosiglizole
Dosage Forms: Tablets
Absorption: The absolute bioavailability of rosiglitazone is 99%. Peak plasma concentrations are observed about 1 hour after dosing. Administration of rosiglitazone with food resulted in no change in overall exposure (AUC), but there was an approximately 28% decrease in Cmax and a delay in Tmax (1.75 hours). These changes are not likely to be clinically significant; therefore, AVANDIA may be administered with or without food.
Interactions:
DrugBank: Interactions for Rosiglitazone
Interactions for Rosiglitazone:
An inhibitor of CYP2C8 (such as gemfibrozil) may increase the AUC of rosiglitazone and an inducer of CYP2C8 (such
as rifampin) may decrease the AUC of rosiglitazone. Therefore, if an inhibitor or an inducer of CYP2C8 is started or
stopped during treatment with rosiglitazone, changes in diabetes treatment may be needed based upon clinical
response.
Chemical IUPAC Name: 5-[[4-[2-(methyl-pyridin-2-yl-amino)ethoxy]phenyl]methyl]thiazolidine-2,4-dione
Chemical Formula: C18H19N3O3S
Half Life: 3-4 hours
Drug Type: Approved Drug
# Accession No: APRD00403
CAS Registry Number: 122320-73-4
Rosiglitazone News (When available)
GlaxoSmithKline upgraded to "buy"Jan 13, 2006 New Ratings ...drugs. The analysts believe that the sales of GlaxoSmithKline's Avandia and Advair drugs would continue to be robust during 2006. ...
Avandia (rosiglitazone maleate): Post-marketing Reports of New ...Jan 5, 2006 PharmaLive.com (press release), ...care providers, we would like to inform you of important new safety information regarding products containing rosiglitazone (ie, Avandia®, Avandamet®, and ...
GSK's Avandia Issue A Class Effect - UBS>GSKJan 6, 2006 New Ratings 0914 GMT [Dow Jones] GlaxoSmithKline's (GSK) Avandia complication is likely to be viewed as affecting the whole class of drugs the treatment belongs to, rather ...
Glaxo Stk Seen Immune To Avandia Side-EffectJan 6, 2006 New Ratings 0757 GMT [Dow Jones] GlaxoSmithKline (GSK) will see very little impact from news that its Avandia diabetes drug has been linked to swelling inside the eye ...
An Association Between Avandia® and Avandamet® and Vision ...Dec 23, 2005 DG News MISSISAUGA, ONTARIO, CANADA -- December 23, 2005 -- Avandia(R) (rosiglitazone maleate) tablets and Avandamet(R) (rosiglitazone maleate/metformin hydrochloride ...
Avandia users report blurry vision, swollen legsJan 7, 2006 Jamaica Observer, The company said it has received "very rare" reports of new or worsening diabetic macular edema in diabetic patients who have taken Avandia or Avandamet. ...
Alert not likely to hurt Glaxo drugJan 6, 2006 CNN/Money Analysts don't expect a warning about the company's Avandia diabetes treatment to impact sales. LONDON (Reuters) - A warning from ...
Drug warning seen minor setback for GlaxoJan 6, 2006 Reuters.uk, LONDON (Reuters) - A warning from US regulators linking GlaxoSmithKline's (GSK.L: Quote, Profile, Research) diabetes drug Avandia to rare cases of swelling in ...
Diabetes drug warning seen minor setback for GlaxoJan 6, 2006 ABC News Jan 6, 2006 — LONDON (Reuters) - A warning from US regulators linking GlaxoSmithKline's diabetes drug Avandia to rare cases of swelling in the back of the ...
Rosiglitazone Linked to Vision ProblemJan 11, 2006 Diabetes Self Management GlaxoSmithKline announced in December that it has received reports of macular edema in people taking its Type 2 diabetes drug rosiglitazone (brand name Avandia ...
Glaxo's Diabetes Drug Tied to Eye Risk, US FDA Says (Update2)Jan 5, 2006 Bloomberg 5 (Bloomberg) -- GlaxoSmithKline Plc's Avandia diabetes drug has been linked to swelling in the back of the eye, which can reduce vision, US regulators said. ...
UPDATE 1-Diabetes drug warning seen minor setback for GlaxoJan 6, 2006 Reuters LONDON, Jan 6 (Reuters) - A warning from US regulators linking GlaxoSmithKline Plc's (GSK.L: Quote, Profile, Research) diabetes drug Avandia to rare cases of ...
OR Provider numberJan 10, 2006 AustralianDoctor.com (subscription), Doctors in Australia and the US have been alerted to new safety information for rosiglitazone (Avandia), after rare post-marketing reports of new onset or ...
Glaxo says two of its drugs cause eye swellingJan 5, 2006 Raleigh Triangle Business Journal, Avandia and Avandamet, as well as a third diabetes drug called Avandaryl that has yet to be released, all contain rosiglitazone, and all have been reported to ...
FDA Warning for 2 Diabetes DrugsJan 5, 2006 WebMD ...are alerting doctors about reports of new or worsening diabetic eye complications in patients with diabetes taking the drugs Avandia or Avandamet. ...
GSK diabetes drug linked to eye problemsJan 6, 2006 Pharma Times (subscription), ...surveillance has revealed a few 'very rare' cases in which macular edema has either occurred or worsened after patients have taken Avandia (rosiglitazone) or ...
UPDATE 1-US FDA, Glaxo warn doctors over diabetes drugsJan 5, 2006 Reuters In most cases, patients taking rosiglitazone -- sold as Avandia, Avandamet and Avandaryl -- reported swelling of the eye known as macular edema, the company ...
UPDATE 2-US FDA, Glaxo warn doctors over diabetes drugsJan 5, 2006 Reuters The drugmaker had received "very rare" reports of swelling of the eye known as macular edema in patients taking two such drugs, Avandia and Avandamet, the ...
Market Report: Dealers dump AstraZeneca as bid hopes fadeJan 13, 2006 Independent, Meanwhile, Dresdner urged investors to move into GlaxoSmithKline, off 1p at 1,456p. It expects the group's diabetes drug, Avandia, and Advair, its asthma ...
Diabetes drug could lead to swellingJan 5, 2006 KVOA.com, ...swelling of the legs and feet. The drugs are Avandia and Avandamet, made by GlaxoSmithKline. The company says it's received "very ...
Diabetes SwellingJan 5, 2006 WNEP-TV, The drugs are Avandia and Avandamet, made by GlaxoSmithKline.The company says it's received "very rare" reports of new or worsening vision problems in diabetic ...
Diabetes drugs may cause blindness: Health CanadaDec 21, 2005 Globe and Mail, The advisory was released after GlaxoSmithKline Inc., the manufacturer of Avandia and Avandamet, informed Health Canada of reports that some diabetics on the ...
Diabetes Drugs Could Lead To SwellingJan 5, 2006 WPBF Channel.com, ...legs and feet. The drugs are Avandia and Avandamet, made by GlaxoSmithKline, which are used to treat type 2 diabetes. The company ...
Health Canada warns of vision problems from 2 diabetes drugsDec 21, 2005 CBC Calgary, The warning concerns two drugs, Avandia and Avandamet, which are prescribed to people with diabetes whose blood-sugar levels haven't been controlled by diet ...
Unlocking the Diabetes-Heart-Disease ConnectionJan 9, 2006 New York Times, Thiazolidinediones, like Actos and Avandia, used to increase insulin sensitivity in diabetes, act by regulating glucose and insulin. ...
SIU doctor aims to teach elder careJan 10, 2006 Belleville News-Democrat, GlaxoSmithKline said last week that it has received "very rare" reports of new or worsening diabetic macular edema in people who have taken Avandia or Avandamet ...
Europe studies eye problem link to diabetes drugsDec 15, 2005 NewKerala.com, Agency said yesterday rare episodes of macular oedema, or swelling of the back of the eye, had been reported with GlaxoSmithKline Plc's Avandia and Takeda ...
US FDA, Glaxo warn doctors over diabetes drugsJan 5, 2006 Reuters In most cases, patients taking the drugs -- Avandia, Avandamet and Avandaryl -- reported swelling of the eye known as macular edema, the company said in the ...
UK Stocks Climb, Led by BP, Royal Dutch Shell; Vodafone GainsJan 6, 2006 Bloomberg The company's Avandia diabetes drug has been linked to swelling in the back of the eye, which can reduce vision, the Food and Drug Administration said in an e ...
BMW, Cap Gemini, Douglas, Euronext: European Equity PreviewJan 5, 2006 Bloomberg GlaxoSmithKline Plc (GSK LN): The Avandia diabetes drug made by Europe's biggest drugmaker has been linked to swelling inside the eye that can reduce vision ...
UK Stocks Including BAE Systems Advance; Glaxo Shares DropJan 6, 2006 Bloomberg Shares of GlaxoSmithKline Plc fell after US regulators said Europe's biggest drugmaker's Avandia diabetes drug has been linked to eye swelling that can reduce ...
Drug stocks mixed, Nuvelo soars on Bayer dealJan 5, 2006 Investor's Business Daily (subscription) The Food and Drug Administration announced late Thursday that an advisory has been issued on Glaxo's diabetes drug Avandia, warning it can worsen the eye ...
Sector movers: Aerospace flies, Drugs retreatJan 6, 2006 ShareCast, Sales of GlaxoSmithKline’s diabetes drug Avandia are unlikely to be impacted in major way by a warning from the US Food and Drug Administration linking it to ...
BAE Systems climbs in stronger London marketJan 6, 2006 Investor's Business Daily (subscription) GlaxoSmithKline (GSK)(GSKGSK) added some pressure to the benchmark by losing 0.5% after it said Thursday that its diabetes drug, Avandia, can cause serious eye ...
BAE Systems, Vodafone gain as FTSE hits new highJan 6, 2006 Investor's Business Daily (subscription) Elsewhere, GlaxoSmithKline (GSK)(GSKGSK) declined 1.2% after it said Thursday that its diabetes drug, Avandia, can cause serious eye problems in some users. ...
AstraZeneca Is The Latest To Join Alzheimer's FightJan 6, 2006 Investor's Business Daily (subscription) ...of the disease. GlaxoSmithKline (GSK) looks to use its $2 billion-a-year diabetes drug, Avandia, to fight Alzheimer's. The theory ...
Business news in briefJan 6, 2006 Philadelphia Inquirer, The company said it has received "very rare" reports of new or worsening diabetic macular edema in diabetic patients who have taken Avandia or Avandamet. - AP. ...
Glaxo, IMI, LSE, Persimmon, SMG: UK, Irish Equity PreviewDec 15, 2005 Bloomberg GlaxoSmithKline Plc (GSK LN): The diabetes drug Avandia, made by Europe's largest drugmaker, and Takeda Pharmaceutical Co.'s Actos will be reviewed by European ...
Glitazone link to macular oedema exploredDec 15, 2005 Reuters The CHMP investigation comes after the EMEA received reports of cases of macular oedema in patients taking GlaxoSmithKline's Avandia/Avandamet (rosiglitazone ...
Trainer Holloway Disqualified Over Drugs16 Jan 2006 Virtual Form Guide, Both Holloway and Hedges denied giving the six-year-old the substance Acepromazine Maleate, commonly known as Ace, and offered that it could have been done by ...
NSW stewards inquiry into tranquiliser findJan 13, 2006 ThoroughbredNews.co.nz, 1pm on Monday, 16 January 2006, following the Analyst's report of the presence of a metabolite of the veterinary tranquiliser Acepromazine Maleate being found ...
NPPA FIXES/REVISES THE PRICES OF BULK DRUGS AND FORMULATIONSDec 27, 2005 Press Information Bureau (press release), Bulk Drugs – The prices of bulk drugs Sodium Penicillin G, Procaine Penicillin G, Benzathine Penicillin G, Phenramine Maleate, Trimethoprim, Pentoxyphylline ...
Bulk drug prices revisedDec 27, 2005 Business Standard, Authority (NPPA) has revised the prices of some bulk drugs and formulations, including Sodium and Procaine Penicillin G, Phenramine Maleate, Trimethoprim and ...
NPPA revamps bulk drugs/formulation pricesDec 27, 2005 NewKerala.com, Meanwhile, the prices of bulk drugs Pheniramine Maleate, Trimethoprim, Rifampicin were revised upwards to Rs 1107/kg, Rs 840/kg, Rs 3560/kg from the existing ...
In fine healthJan 8, 2006 Business Standard, ...companies. The company has also recently received tentative US FDA approval for its anti-diabetic drug, Rosiglitazone Maleate tablets. ...
BioDelivery Sciences Files IND for BEMA(TM) LA, a treatment for ...Jan 9, 2006 dBusinessNews Triangle (press release), Needless to say, with our existing NDA for Emezine(R) (prochlorperazine maleate) under review at FDA; BEMA(TM) Fentanyl entering Phase III and now with our ...
Drug prices may face a small hikeDec 28, 2005 Andhra Cafe, Also, prices of other bulk drugs such as pheniramine maleate and timethoprim have been raised by 3.65 and 20 per cent respectively. ...
Easing IBSJan 4, 2006 WOWT, Researchers are now testing the use of another drug, tegaserod maleate, can help prevent overgrowth of bacteria for longer periods of time.
Irritable Bowel Syndrome (IBS)Dec 16, 2005 WSOCtv.com, Tegaserod maleate (Zelnorm®) is approved for women with IBS who have constipation as their main symptom. There aren't any conclusive diagnostic tests for IBS. ...
An Association Between Avandia® and Avandamet® and Vision ...Dec 23, 2005 DG News MISSISAUGA, ONTARIO, CANADA -- December 23, 2005 -- Avandia(R) (rosiglitazone maleate) tablets and Avandamet(R) (rosiglitazone maleate/metformin hydrochloride ...
Pen G derivatives prices reduced by up to 32%Dec 27, 2005 Financial Express, The authority also announced hike in prices of bulk pheniramine maleate (3.65%), trimethoprim (20%) and rifampicin (2.3%), citing rise in prices of raw ...
Sensex snaps 5-day rally; rupee climbsDec 14, 2005 Gulf Times, The company won approval to sell 2-milligram, 4-milligram and 8-milligram tablets of rosiglitazone maleate in the US, the drug regulator said in an e-mailed ...
Mother explains horrors of local OTC drug abuseDec 15, 2005 Atlanticville, C (CCC), a nickname for the cough medicine Coricidin HBP Cold & Cough, the most popular brand of dextromethorphan (DXM) and chlorpheniramine maleate that is ...
In fine healthJan 8, 2006 Business Standard, ...companies. The company has also recently received tentative US FDA approval for its anti-diabetic drug, Rosiglitazone Maleate tablets. ...
An Association Between Avandia® and Avandamet® and Vision ...Dec 23, 2005 DG News MISSISAUGA, ONTARIO, CANADA -- December 23, 2005 -- Avandia(R) (rosiglitazone maleate) tablets and Avandamet(R) (rosiglitazone maleate/metformin hydrochloride ...
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