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Reserpine
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DRUG INFO
Reserpine
Drug Name:
Reserpine
Indication: Foe the treatment of hypertension
Pharmacology: Reserpine is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage. The antihypertensive actions of Reserpine are a result of its ability to deplete catecholamines from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral resistance.
Mechanism Of Action: Reserpine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines.
Drug Category: Antipsychotics; Antihypertensive Agents; Peripheral Adrenergic Inhibitors; ATC:C02AA02
Brand Names/Synonyms: Serpalan (TN); Reserpine (JP14/USP); Cam-Ap-Es; Chlorothiazide And Reserpine; Chlorothiazide W/ Reserpine; Chlorothiazide-Reserpine; Demi-Regroton; Diupres-250; Diupres-500; Diutensen-R; Dralserp; H.R.-50; Hiserpia; Hydralazine Hcl, Hydrochlorothiazide And Reserpine; Hydralazine Hcl-Hydrochlorothiazide-Reserpine; Hydralazine, Hydrochlorothiazide W/ Reserpine; Hydrap-Es; Hydro-Reserp; Hydro-Serp "25"; Hydro-Serp "50"; Hydrochlorothiazide W/ Reserpine; Hydrochlorothiazide W/ Reserpine And Hydralazine; Hydroflumethiazide And Reserpine; Hydromox R; Hydropres 25; Hydropres 50; Hydroserpine Plus (R-H-H); Metatensin #2; Metatensin #4; Naquival; Novoreserpine; Rau-Sed; Regroton; Renese-R; Reserfia; Reserpine; Reserpine And Hydrochlorothiazide; Reserpine And Hydrochlorothiazide-50; Reserpine And Hydroflumethiazide; Reserpine, Hydralazine Hcl And Hydrochlorothiazide; Reserpine, Hydrochlorothiazide, And Hydralazine Hcl; Salutensin; Salutensin-Demi; Sandril; Ser-A-Gen; Ser-Ap-Es; Serpalan; Serpanray; Serpasil; Serpasil-Apresoline; Serpasil-Esidrix #1; Serpasil-Esidrix #2; Serpate; Serpivite; Trichlormethiazide W/ Reserpine; Unipres
Dosage Forms: TABLET
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: Not Available
Chemical Formula: C33H40N2O9
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00472
CAS Registry Number: 50-55-5
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Reserpine News
(When available)
Data Show Cost-Effectiveness of NitroMed's BiDil Through Reduced ... Dec 13, 2005
PharmaLive.com (press release), 12, 2005 - According to a pharmacoeconomic analysis titled "Cost-Effectiveness of Fixed-Dose Combination of Isosorbide Dinitrate and Hydralazine Therapy for ...
NitroMed Promotes Michael Sabolinski, MD to the Position of Chief ... Jan 6, 2006
Genetic Engineering News, ...and participate in certain key decision making processes relative to the development of BiDil(R) (isosorbide dinitrate/hydralazine hydrochloride) outside of ...
NAACP and NitroMed Announce Partnership to Narrow Disparities in ... Dec 14, 2005
PharmaLive.com (press release), NitroMed is the maker of BiDil(R) (isosorbide dinatrate/ hydralazine HCl), a prescription medicine approved this year by the Food and Drug Administration (FDA ...
NitroMed to Present at 24th Annual JPMorgan Healthcare Conference Jan 4, 2006
Genetic Engineering News, ...of Lexington, Massachusetts is a research-based emerging pharmaceutical company and the maker of BiDil(R) (isosorbide dinitrate/hydralazine hydrochloride), an ...
Major new medication promising for black heart patients Jan 2, 2006
Fort Lauderdale Sun Sentinel, The two drugs -- hydralazine hydrochloride and isosorbide dinitrate -- increase nitric oxide that relaxes and dilates blood vessels to improve blood flow. ...
A cost effective heart failure drug hits the market! Dec 17, 2005
MedIndia, The comparison was made in patients who took a medication with two active drug ingredients, isosorbide dinitrate and hydralazine (ISDN/HYD), to those in ...
NitroMed and Boston Scientific Complete Research Collaboration Dec 29, 2005
Finanzen.net, ...of Lexington, Massachusetts is a research-based emergingpharmaceutical company and the maker of BiDil(R) (isosorbidedinitrate/hydralazine hydrochloride), an ...
Heart Failure Drug for Blacks a Good Deal Dec 13, 2005
Forbes It is actually a combination of two older drugs -- hydralazine, an anti-hypertensive agent that relaxes the arteries, and isosorbide dinitrate, an anti-anginal ...
Study says heart drug for blacks cuts costs Dec 12, 2005
Pittsburgh Post Gazette, ...because the maker, NitroMed Inc., won 13 years of patent protection for a combination of two old drugs -- isosorbide dinitrate and hydralazine -- available in ...
NAACP and NitroMed Announce Partnership to Narrow Disparities in ... Dec 14, 2005
PharmaLive.com (press release), NitroMed is the maker of BiDil(R) (isosorbide dinatrate/ hydralazine HCl), a prescription medicine approved this year by the Food and Drug Administration (FDA ...
Strike threat could impact on Nissan production, warns Amicus Jan 11, 2006
Auto Industry, Workers at Unipres (UK) Ltd in Washington Tyneside, which supplies body parts to Nissan and Honda, are being balloted for industrial action over plans to ...
Reports round-up Jan 10, 2006
Socialistworker.co.uk, Workers at car component company Unipres in Washington, Tyneside, are balloting for industrial action over plans to introduce Saturday working. ...
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