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Pipobroman
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DRUG INFO
Pipobroman
Drug Name:
Pipobroman
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Indication: For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia.
Pharmacology: Pipobroman is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Pipobroman has well documented clinical activity against polycythemia vera and essential thrombocythemia.
Mechanism Of Action: The mechanism of action is uncertain but pipobroman is thought to alkylate DNA leading to disruption of DNA synthesis and eventual cell death.
Drug Category: Antineoplastic Agents; ATC:L01AX02
Brand Names/Synonyms: A 1803; A-8103; Amedel; NSC-25154; Pipobroman; Pipobroman [Usan:Inn]; Pipobromanum [Inn-Latin]; Vercyte
Dosage Forms: TABLET (25 mg)
Absorption: Well absorbed from the GI tract.
Interactions: Not Available
Chemical IUPAC Name: 3-bromo-1-[4-(3-bromopropanoyl)piperazin-1-yl]-propan-1-one
Chemical Formula: C10H16Br2N2O2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00693
CAS Registry Number: 54-91-1
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