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Piperazine
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DRUG INFO
Piperazine
Drug Name:
Piperazine
Indication: Used as alternative treatment for ascariasis caused by Ascaris lumbricoides(roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm).
Pharmacology: Piperazine is an antinematodal agent indicated as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). Piperazine is especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children.
Mechanism Of Action: Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.
Drug Category: Antinematodal Agents; Anthelmintics; ATC:P02CB01; ATC:R03DA09
Brand Names/Synonyms: Anatensol; Antepan; Antepar; Antiren; Asca-Trol No. 3; Bryrel; Dapotum; Diethylenediamine; Diethyleneimine; Dispermine; Entacyl; Eraverm; Fluphenazine Dihydrochloride; Hexahydropyrazine; Lumbrical; Lyogen; Moditen; Multifuge; Omca; Pacinol; Permitil; Piperazidine; Piperazin; Piperazine; Piperazine Anhydrous; Piperazine Citrate; Piperazine, Anhydrous; Pipersol; Prolixin Decanoate; Pyrazine Hexahydride; Pyrazine, Hexahydro-; Siqualone; Tasnon; Tensofin; UN 2579; Upixon; Uvilon; Valamina; Vermex; Vermidol; Worm-Away; Wurmirazin
Dosage Forms: CAPSULE; DROPS; LIQUID; POWDER; POWDER FOR SOLUTION; SOLUTION; SUSPENSION; SYRUP; TABLET
Absorption: Rapidly absorbed from the gastrointestinal tract
Interactions: Not Available
Chemical IUPAC Name: piperazine
Chemical Formula: C4H10N2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00225
CAS Registry Number: 110-85-0
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Piperazine News
(When available)
Low-level exercise delays heart failure, markedly extends lives ... 15 Jan 2006
Xagena.it, The ) final training intensity was quite low as evidenced by the absence of a training-induced increase in skeletal muscle citrate synthase activity or body ...
Sidnafil Citrate is a medicine, not stimulant warns doctors Jan 3, 2006
Hindu, ..."These tablets which contain Sidnafil Citrate are specific drugs that are effectively used for the treatment of erectile dysfunction. ...
Gadot Biochemicals seeks to acquire co in US or Europe Jan 12, 2006
Globes, ...strategy, marking as growth sources several added value products related to the production of citric acid, such as crystalline fructose and Tri-Sodium Citrate. ...
PURE Bioscience Board Elects D. Michael Sitton to its Board of ... Jan 12, 2006
Business Wire (press release), ...in the Company's growth as I tap the resources in my diverse background to help advance PURE Bioscience's new silver dihydrogen citrate platform technology ...
Tough competition for Pfizer Viagra Jan 5, 2006
CNN-IBN, Viagra is mainly prescribed for erectile dysfunction. The main ingredient in the magic blue pill is Sildenafil Citrate. Sildenafil ...
Osteoporosis International Publishes Study Showing the 'BEST' Way ... Dec 20, 2005
PR Newswire (press release), Weight-Bearing Regimen and Calcium Citrate Proven to Increase Bone Mineral Densityin Four-Year Research Study TUCSON, Ariz., Dec. ...
Osteoporosis International Publishes Study Showing the 'BEST' Way ... Dec 20, 2005
Biotech Intelligence (press release), ...at The University of Arizona which confirmed that a specific regimen of weight-bearing and resistance exercises, combined with calcium citrate supplement over ...
Seek constipation's cause Dec 27, 2005
Contra Costa Times, Q For several months I have been taking large daily doses of magnesium citrate (1200 mg) in an attempt to deal with my long-term constipation (more than 30 ...
- By Our Correspondent Dec 21, 2005
The Asian Age, A spokesperson for Ranbaxy India Limited (RIL) said that Pfizer, the original innovator of Viagra (Sildenefil Citrate), has just come into the market and so it ...
FTC chief concerned about drug patent deals Jan 11, 2006
Reuters The patent settlement challenged in that case involved AstraZeneca's Tamoxifen Citrate, the most widely prescribed drug for breast cancer treatment. ...
Pfizer Introduces RFID Technology to Combat Counterfeiting ... Jan 8, 2006
MoreRFID (press release), RFID technology is being added to all Viagra(R) (sildenafil citrate) sold in the US to enable pharmacies and wholesalers to verify the unique electronic ...
Cephalon, Inc. Announces Agreement with Mylan Pharmaceuticals Inc. ... Jan 10, 2006
PharmaLive.com (press release), ...markets four proprietary products in the United States: PROVIGIL, GABITRIL(R) (tiagabine hydrochloride), ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II ...
Pfizer adds radio tags to Viagra to combat fakes Jan 9, 2006
Pharma Times (subscription), The product to receive the electronic tagging system is erectile dysfunction treatment Viagra (sildenafil citrate), which is one of the most counterfeited ...
Bio/Data Corporation Releases New Control Plasma for vW Testing Jan 11, 2006
Genetic Engineering News, Bio/Data's other reagents for vW testing include: lyophilized platelets, ristocetin, sodium citrate, tris buffered saline, vW abnormal control plasma and vW ...
Double the Size of Your Portfolio in 60 Days with Enzyte Jan 10, 2006
I-Newswire.com (press release) ...which usually show the product's trade name ( eg, Viagra ) in big letters and the scientific-sounding chemical name ( eg, sildenafil citrate ) in parentheses ...
VIAGRA: THE WONDER DRUG Jan 4, 2006
Star of Mysore, ...regain sexual function. Oral tablets like Sildenifil citrate (Viagra), Tadalafil, Yohimbine, etc are routinely used. Injections like ...
Sports and Substance Abuse Jan 10, 2006
Medscape (subscription) Use of drugs like clomiphene citrate, which masks the androgenic effects of steroids, and diuretics, which decrease the accumulation of fluid weight of these ...
Viagra a medicine, not stimulant Jan 4, 2006
Newindpress, ...‘‘These tablets which contain sidnafil citrate are specific drugs that are effectively used for the treatment of erectile dysfunction. ...
Erectile Dysfunction: New Agents, New Data Dec 29, 2005
Medscape (subscription) Sildenafil citrate at a 25- or 50-mg oral daily dose in the morning, or tadalafil at a 5-mg oral dose 3 times weekly in the morning, was administered to 3 men ...
Aspirin Resistance: Fact and Fiction Dec 27, 2005
Medscape (subscription) It is an in vitro quantitative measurement of platelet adhesion and aggregation that requires whole blood collected in 3.8% sodium citrate. ...
Erectile Dysfunction Drug Viagra Launched In India By Pfizer Dec 21, 2005
MedIndia, Infact, a generic version of Viagra (Sildenafil Citrate) was available in India much before the launch of the launch of the pill in the US drug market before 7 ...
Is there a quick fertility drug I can use? Dec 16, 2005
The Monitor, Uganda, ...a woman is found with a problem of ovulation, she is likely to benefit from the so-called fertility drugs of which one common one is called Clomiphene Citrate. ...
Viagra launch could face stiff protest in MP Dec 23, 2005
Business Standard, ...of Viagra from Pfizer will face stiff protest in Madhya Pradesh, particularly from small-scale sector units that manufacture sildenafil citrate—the main ...
Mumbai not so hard on Viagra Dec 20, 2005
Mid-Day Mumbai, Sandeep Ashar and Vrushali Lad report. The original sex pill Viagra (sildenafil citrate) for erectile dysfunction among males is finally here. ...
Take this: Real Viagra comes to India! Dec 20, 2005
Times of India, The original blue pill will cost Rs 594 (Rs 463 for 50 mg) as against Rs 25 or less for the desi or generic version of the drug known as sildenafil citrate. ...
How Viagra stood up as a product Dec 20, 2005
Daily News & Analysis, Dr Peter Ellis, executive director, global R&D, recalled the day in September 1993 when Pfizer bosses were ready to abandon research on sildenafil citrate. ...
GTx Reports Positive Phase III Trial Interim Analysis Results Dec 15, 2005
PR Newswire (press release), ...experienced highly statistically significant increases in bone mineral density (BMD) after one year of treatment with ACAPODENE(R) (toremifene citrate) 80 mg ...
Pfizer to sell Viagra @ Rs 20 in India Dec 18, 2005
Economic Times, The domestic market is already cluttered with almost a dozen Viagra clones (generic versions containing the active ingredient sildenafil citrate). ...
Wonder pill’s here Dec 20, 2005
Calcutta Telegraph, In a market flooded with at least seven local brands of sildenafil citrate tablets selling at much cheaper prices, it is difficult to say how much impact Pfizer ...
PURE Bioscience Reports First Quarter Results Dec 16, 2005
Genetic Engineering News, Michael L. Krall, President and CEO of PURE Bioscience, stated, "We have introduced our silver dihydrogen citrate (SDC) antimicrobial to numerous domestic and ...
Pfizer to launch Viagra in India this week Dec 12, 2005
Rediff, Pfizer, the inventor of Sildenafil Citrate, is planning to roll out its blockbuster erectile disfunction drug brand, Viagra, in India this week after a long ...
Vaccination drive against filaria Jan 6, 2006
Hindustan Times, Singh has constituted 25 teams comprising paramedical staff to visit door to door from January 9 to 14 administering diethyl carbamazine citrate tablets to ...
The cost and the claims Jan 3, 2006
Telegraph.co.uk, Contains: water, glycerol, Vitamin C, Vitamin E, sodium citrate, stabiliser (Xanthan gum), citric acid, sodium chloride (salt), preservative (sorbic acid ...
Manforce rated as No1 erectile dysfunction drug by ORG-IMS Jan 3, 2006
India Infoline.com, As per ORG-IMS audit dated Oct’2005, the total market for ED related drugs in India is about 95 Crore with a yearly growth of 9%. Sildenafil citrate is the ...
Study: Exercise & Calcium Strengthen Bones Jan 5, 2006
KOLD-TV, ...to be supplied by their food intake. They took Citracal calcium citrate in the study. The regimen includes six core exercises: Leg ...
Rachel Emrick avoids illness and derives energy from eating right Dec 31, 2005
Lufkin Daily News, ...system was tweaked as she learned the body's ability to absorb nutrients depended on the supplement's chemical form — like calcium citrate, which cured her ...
Viagra's on the way to India, but there's stiff competition Dec 21, 2005
Australian, Pfizer had been investigating the cardiovascular effects of sildenafil citrate when it stumbled upon its side effect as an impotence drug. ...
Viagra debuts in India at Rs 463 Dec 20, 2005
Financial Express, MUMBAI, DEC 20: Pfizer India on Tuesday announced the launch of its $1.7 billion erectile dysfunction (ED) drug Viagra (sildenafil citrate) in India, nearly ...
'Viagra misuse might make people go berserk' Dec 27, 2005
Times of India, Viagra (sildenafil citrate) manufacturer Pfizer is launching the drug in the Indian market this week, seven years after it was introduced in global markets.
Pfizer set to launch Viagra next week Dec 17, 2005
Sify, ...here. Penegra was the name under which Zydus Cadila launched its version of sildenafil citrate, the active ingredient in Viagra. ...
Counting on the Viagra brand in India Dec 21, 2005
International Herald Tribune, ...are treatments. One tablet of Viagra, or sildenafil citrate, is sold every six seconds worldwide, according to Pfizer. But Viagra's ...
Human trials for new Viagra uses begin Dec 21, 2005
Financial Express, MUMBAI, DEC 21: Pfizer India has commenced clinical trials in India on certain new uses of sildenafil citrate, the active ingredient in its blockbuster ...
Pfizer to bring products from global portfolio Dec 22, 2005
Business Standard, The drug, sildenafil citrate, with serious contraindications is being launched in select cities as it is structured to be sold on the prescription of a ...
FDA Issues Approvable Letter for VIVITROL(TM) (Formerly VIVITREX(R ... Dec 28, 2005
Finanzen.net, ...products in theUnited States: PROVIGIL(R) (modafinil) (C-IV), GABITRIL(R) (tiagabinehydrochloride), ACTIQ(R) (oral transmucosal fentanyl citrate) (C-II)and ...
Pfizer launches Viagra in India Dec 20, 2005
Webindia123, Pfizer today announced the launch of VIAGRA (sildenafil citrate), their breakthrough treatment for Erectile Dysfunction (ED), in the Indian market. ...
Jharkhand Chemists to Boycott Viagra Dec 30, 2005
MedIndia, Association (JCDA). The manufacturer of Viagra, which is chemically sildenafil citrate, is launching the product in India next week. Sinha ...
Druglords descend on R&D haven Dec 25, 2005
Calcutta Telegraph, Similarly, Pfizer India, which launched the Viagra only last week, is also conducting human clinical trials on new uses of sildenafil citrate, the compound ...
Cephalon, Inc. Completes Acquisition of Zeneus Holdings Limited Dec 22, 2005
Yahoo! News (press release) ...products in the United States: PROVIGIL® (modafinil) [C-IV], GABITRIL® (tiagabine hydrochloride), ACTIQ® (oral transmucosal fentanyl citrate) [C-II] and ...
Cephalon, Inc. Completes Acquisition of Zeneus Holdings Limited Dec 22, 2005
Boursorama, ...products in the United States: PROVIGIL(R) (modafinil) [C-IV], GABITRIL(R) (tiagabine hydrochloride), ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II] and ...
MGI PHARMA Provides Update on Aquavan(R) Injection Program; Top ... Dec 21, 2005
Business Wire (press release), ...of four different initial bolus doses of Aquavan Injection (2.0, 5.0, 6.5, or 8.0 mg/kg) or midazolam (0.02 mg/kg) following pretreatment with fentanyl citrate ...
TAMIFLU: DANGEROUS AND INEFFECTIVE? Dec 26, 2005
Free Market News Network, The oral suspension liquid, meanwhile, contains: oseltamivir; saccharin sodium (E954); sodium benzoate (E211); sodium dihydrogen citrate (E331 (a)); sorbitol ...
The many functions of calcium Dec 26, 2005
New Straits Times, ...consider a calcium supplement. Calcium supplements are available in many forms and the citrate form is found to be better absorbed.
Cephalon, Inc. Announces Agreement with Ranbaxy Laboratories ... Dec 22, 2005
Yahoo! News (press release) ...markets four proprietary products in the United States: PROVIGIL, GABITRIL® (tiagabine hydrochloride), ACTIQ® (oral transmucosal fentanyl citrate) [C-II] and ...
Preventing bone loss is best protection Dec 13, 2005
Newsday, ...them at night. Calcium citrate is a better choice, in my opinion, but bone health is not really about the calcium. It's about the ...
Why Viagra Spam Floods Your Email Dec 13, 2005
Emediawire (press release), ...product associated with spammers. Many overseas pharmacies are selling sildenafil citrate, the ingredient in Viagra. The product they ...
The Strong Connection Between Viagra and Spam Dec 13, 2005
Cheap Web Hosting Directory, The strong connection between spam and Viagra may be as follows: Many overseas pharmacies are selling sildenafil citrate, the ingredient in Viagra. ...
Community Association Still Going Strong: Old Mystic group ... Dec 22, 2005
Shore Publishing, Since 1974, the OMCA's mission has been to “provide a closer association among the neighbors that are in the Stonington, Groton, Mystic area, and encourage ...
abLA "LA Picks for 2006" Jan 3, 2006
Art.Blogging.LA, ...we have to an LA-enniel or West Coast-enniel, I'm looking forward to seeing the artists chosen by Elizabeth Armstrong, Karen Moss (both from OMCA) and Rita ...
Study briefs, 1/03: Antipsychotics, kidney disease, foot sores Jan 3, 2006
Lincoln Journal Star, The drugs included the conventional antipsychotics Tindal, Thorazine, Prolixin, Permitil, Serentil, Trilafon, Mellaril, Stelazine, Vesprin, Taractan, Haldol ...
CATIE Phase I Helps Clinicians Tailor Schizophrenia Treatment Jan 12, 2006
Psychiatric Times, ...who discontinued their Phase II treatment and were given open treatment with clozapine, one of the atypicals, fluphenazine decanoate (Prolixin) or dual ...
Study briefs, 1/03: Antipsychotics, kidney disease, foot sores Jan 3, 2006
Lincoln Journal Star, The drugs included the conventional antipsychotics Tindal, Thorazine, Prolixin, Permitil, Serentil, Trilafon, Mellaril, Stelazine, Vesprin, Taractan, Haldol ...
EU panel demands more info on flavour compounds Jan 10, 2006
FoodNavigator.com, ...information. The 18 flavour substances were all pyrazine derivatives. Pyrazine is a hygroscopic white solid and is an aromatic nitrogen. ...
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