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Phytonadione
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DRUG INFO
Phytonadione
Drug Name:
Phytonadione
Indication: For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Pharmacology: Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Mechanism Of Action: Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hepatic precursors of coagulation factors II, VII, IX and X. Gamma-carboxylation converts these inactive precursors into active coagulation factors which are secreted by hepatocytes into the blood. Supplementing with Phytonadione results in a relief of vitamin K deficiency symptoms which include easy bruisability, epistaxis, gastrointestinal bleeding, menorrhagia and hematuria.
Drug Category: Antifibrinolytic Agents; Vitamins (Vitamin K);
Brand Names/Synonyms: Phylloquinone; VITAMIN K1; Mephyton (TN); Phytonadione (JP14/USP); AquaMEPHYTON; Aquamephyton; Konakion; M.V.I. Pediatric; Mephyton; Phytonadione; Vitamin K1; Vitaped; α-Phylloquinone; 1,4-Naphthoquinone, 2-methyl-3-phytyl-; 2', 3'-trans-Vitamin K1; 2-Methyl-3-phythyl-1,4-naphthochinon; 3-Phytylmenadione; Antihemorrhagic vitamin; Aqua-Mephytin; Combinal K1; K-Ject; Kativ N; Kephton; Kinadion; Menadione; Mono-Kay; Monodion; Phyllochinon; Phythyl-menadion; Phythyl-menadion (GERMAN); Phytomenadione; Phytylmenadione; Synthex P; Vitamin K; Vitamin K1 (VAN)
Dosage Forms: LIQUID
Absorption: Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Interactions: Interactions for Phytonadione:
Temporary resistance to prothrombin-depressing anticoagulants may result, especially when larger doses of phytonadione are used. If relatively large doses have been employed, it may be necessary when reinstituting anticoagulant therapy to use somewhat larger doses of the prothrombin-depressing anticoagulant, or to use one which acts on a different principle, such as heparin sodium.
Laboratory Tests
Prothrombin time should be checked regularly as clinical conditions indicate.
Chemical IUPAC Name: 2-methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione
Chemical Formula: C31H46O2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00464
CAS Registry Number: 84-80-0
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Phytonadione News
(When available)
New labeling rules a boon for consumers with allergies Jan 11, 2006
Amarillo.com (subscription), ...written in Hebrew? Try figuring out what phylloquinone is or sodium selenate. Puhlease. Now there's relief in sight. Recently, the ...
The Nature of Nutrients 16 Jan 2006
Standard-Speaker, They also need adequate protein to form their basic framework, vitamin K to maintain structural proteins and two other bone strengtheners that we're probably ...
Reduce platelet aggregation, blood clotting, inflammation, nervous ... Jan 12, 2006
Health24.com, Vitamin E seldom causes toxicity, even when massive daily doses are taken. Vitamin K, essential for blood clotting, is seldom included in supplements. ...
Supplemental reading: your guide to vitamins Jan 3, 2006
Kentucky.com, ...women. But talk to your doctor before taking vitamin K supplements if you are taking a blood thinner, because K can promote clotting. ...
Britain Outlaws Ketamine Dec 29, 2005
Prensa Latina, Ketamine -also known as Green, K, special K, super K or Vitamin K- is category C of the most dangerous drugs (cannabis) due to the damage it may inflict on the ...
100 dogs die after eating toxic food Jan 10, 2006
Cleveland Plain Dealer, Treatment consists of fluids, antibiotics, vitamin K and plasma, said Terry Hamilton, a veterinarian at the Veterinary Referral Clinic and Emergency Center in ...
UK bans Ketamine from recreational use Jan 1, 2006
Food Consumer, The most common names for ketamine are K, special K, cat valium, and vitamin K. (Please see the Street Terms text box for additional names.).
Books give a leg up on fitness resolutions Jan 8, 2006
London Free Press, ...mindful morsels" to remind us why something so yummy is so good for us (Swiss chard contains more than 150 percent of the recommended daily value of vitamin K ...
Could Vitamin D actually be a miracle in a bottle? Jan 2, 2006
Scotsman, ...selenium because selenium transports the vitamin around the body, and calcium supplements are ineffective unless you are getting enough Vitamin K, which helps ...
Was Popeye On To Something? Jan 6, 2006
WRAL.com, Spinach is a great source of beta-carotene, which your body converts to vitamin A, as well as vitamin C, folate, vitamin K, magnesium and potassium. ...
How to stop that dysfunctional period cycle Jan 5, 2006
Deccan Herald, Dietary supplements like raisins, sweet potato, and green leafy vegetables as they are rich in Vitamin K and evening primrose oil are very useful. ...
Ariel Sharon in Critical Condition After Brain Surgery for Stroke Jan 5, 2006
CNN When the hemorrhage is related to use of blood thinners, "vitamin K or fresh frozen plasma can be tried to overcome the effect of the Coumadin.". ...
Skunk on Bellingham airport runway diverts planes Jan 5, 2006
Seattle Times, She took the skunk back to the Sardis rehabilitation center in Custer, where it's receiving daily vitamin K injections, which serve as an antidote to the rat ...
Special K party drug reclassified Dec 31, 2005
DeHavilland, Day. The powerful hallucinogen, nicknamed "special K" or "vitamin K", has been re-classified as a Class C drug by the Home Office. ...
Horse tranquilliser used by clubbers is added to banned list Dec 28, 2005
Scotsman, The powerful hallucinogen - also nicknamed Special K, tekno smack and vitamin K - was invented in the Parke-Davies laboratories, in Michigan, the United States ...
Horse tranquilliser 'club drug' to be banned Dec 28, 2005
Telegraph.co.uk, Ketamine will become a Class C drug from January 1. The powerful hallucinogen - nicknamed "special K", "tekno smack" and "vitamin K" - is currently legal. ...
Mouse and rat baits pose risk to pets Dec 27, 2005
Charlotte Sun-Herald, An antidote (a form of vitamin K) is commonly given for 30 days and then the blood is tested for normal clotting time before the vitamin K is discontinued. ...
Horse tranquilliser faces ban Dec 29, 2005
Glasgow Evening Times, Nicknamed special K, tekno smack and vitamin K, its usage has rocketed and the powerful hallucinogen will become a Class C drug in the new year. ...
Skunk on mend after airport adventure Jan 4, 2006
Bellingham Herald, ...head out of the box. So he'll spend the next few weeks at Sardis, getting daily vitamin K injections. The vitamin aids blood coagulation ...
Roy pIrRUNg: Calcium is beneficial Dec 23, 2005
Sheboygan Press, Excess calcium can reduce the absorption of zinc and iron and impair the metabolism of vitamin K, and can cause heart or lung failure. ...
Sweet little mystery Dec 23, 2005
Times Online, BABIES given a supplement of vitamin K at birth have a significantly reduced risk of growing up to be alcoholics, a new study from Denmark indicates. ...
Makeover 911 : Sneak peek at presents Dec 22, 2005
INQ7.net, Cernor Vitamin K eye cream is a favorite and well-guarded secret among show-biz personalities who have notoriously late work hours. ...
Dietary supplements: Know the benefits, risks Dec 24, 2005
The Southern, Examples of common drug interactions include magnesium and cancer drugs; Vitamin K and a blood thinner; and St. John's Wort and anti-depression drugs. ...
Toddler with rare disease finds treatment overseas Dec 20, 2005
The Grand Rapids Press, His failing eyesight, combined with his liver being unable to produce normal amounts of vitamin K to clot blood, led to the diagnosis. ...
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