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Phenylephrine
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DRUG INFO Phenylephrine
Drug Name:
Phenylephrine
Indication: For the treatment of ophthalmic disorders (hyperaemia of conjunctiva, posterior synechiae, acute atopic), nasal congestion, hemorrhoids, hypotension, shock, hypotension during spinal anesthesia, paroxysmal supraventricular tachycardia. It is also used as an aid in the diagnosis of heart murmurs and for prolongation of spinal anesthesia
Pharmacology: Phenylephrine is a powerful vasoconstrictor. It is used as a mydriatic, nasal decongestant, and cardiotonic agent. Phenylephrine is a postsynaptic alpha-receptor stimulant with little effect on the beta receptors of the heart. Parenteral administration of Phenylephrine causes a rise in systolic and diastolic pressures, cardiac output is slightly decreased and peripheral resistance is considerably increased, most vascular beds are constricted; renal, splanchnic, cutaneous, and limb blood flows are reduced but coronary blood flow is increased. Pulmonary vessels are constricted, and pulmonary arterial pressure is raised. This alpha receptor sympathetic agonist is also used locally because its vasoconstrictor and mydriatic action.
Mechanism Of Action: Phenylephrine produces its ophthalmic and systemic actions by acting on alpha 1 adrenergic receptors in the pupillary dilator muscle and the vascular smooth musle, resulting in contraction of the dilator muscle and contraction of the smooth muscle in the arterioles of the conjunctiva and peripheral vasoconstriction. Phenylephrine decreases nasal congestion by acting on alpha 1 adrenergic receptors in the arterioles of the nasal mucosa to produce constriction.
Drug Category: Adrenergic alpha-Agonists; Cardiotonic Agents; Nasal Decongestants; Sympathomimetics; Vasoconstrictor Agents; Mydriatics; ATC:C01CA06; ATC:R01AA04; ATC:R01AB01; ATC:R01BA03; ATC:S01FB01; ATC:S01GA05
Brand Names/Synonyms: Adrianol; Ak-Dilate; Ak-Nefrin; Alcon Efrin; Alconefrin Nasal Drops 12; Alconefrin Nasal Drops 25; Alconefrin Nasal Drops 50; Alconefrin Nasal Spray 25; Biomydrin; Dilatair; Dimetane; Dionephrine; Doktors; Duration; Fenilefrina [Inn-Spanish]; HSDB 3383; I-Phrine; Isophrim; Isophrin; Isopto Frin; L-Phenylephedrine; L-Phenylephrine; M-Methylaminoethanolphenol; M-Oxedrine; M-Sympathol; M-Sympatol; M-Synephrine; Mesaton; Mesatone; Mesatonum; Metaoxedrin; Metaoxedrine; Metaoxedrinum; Metasympatol; Metasynephrine; Metsatonum; Mezaton; Minims Phenylephrine; Mydfrin; Neo-Synephrine; Neo-Synephrine Nasal Drops; Neo-Synephrine Nasal Jelly; Neo-Synephrine Nasal Spray; Neofrin; Neophryn; Neosynephrine; Nostril; Nostril Spray Pump; Nostril Spray Pump Mild; Ocu-Phrin Sterile Eye Drops; Ocugestrin; Phenoptic; Phenylephrine; Phenylephrine, I-; Phenylephrine, L-; Phenylephrinhydrochlorid; Phenylephrinum [Inn-Latin]; Prefrin; Prefrin Liquifilm; Pyracort D; Relief Eye Drops for Red Eyes; Rhinall; Spersaphrine; Vicks Sinex; Visadron
Dosage Forms: Ophthalmic Solution; Nasal Solution; Solution (IM, IV, IV infusion and subcutaneous); Gel; Cream; Ointment; Suppository
Absorption: Not Available
Interactions:
DrugBank: Interactions for Phenylephrine
Interactions for Phenylephrine:
Vasopressors, particularly metaraminol, may cause serious cardiac arrhythmias during halothane anesthesia and
therefore should be used only with great caution or not at all.
MAO Inhibitors
The pressor effect of sympathomimetic pressor amines is markedly potentiated in patients receiving monoamine
oxidase inhibitors (MAOI). Therefore, when initiating pressor therapy in these patients, the initial dose should be
small and used with due caution. The pressor response of adrenergic agents may also be potentiated by tricyclic
antidepressants.
Chemical IUPAC Name: 3-(1-hydroxy-2-methylamino-ethyl)phenol
Chemical Formula: C9H13NO2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00365
CAS Registry Number: 59-42-7
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Phenylephrine News (When available)
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Single-Day Famvir Treatment Found to Shorten the Duration of ... Dec 18, 2005 Yahoo! News (press release) ...that a single day of treatment with the antiviral Famvir® (famciclovir) stopped the progression to a full outbreak or shortened the duration of an outbreak in ...
No reduction in six-month duration of supended MLAs: CM Dec 16, 2005 Webindia123, Maharashtra Chief Minister Vilasrao Deshmukh today said there would be no reduction in the suspension period period of the three BJP MLAs, who were suspended ...
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Vicks VapoRub touted as fingernail therapy, too Jan 2, 2006 Fort Wayne Journal Gazette, I have read of the use of Vicks VapoRub for toenails troubled with some types of fungus. I decided that what is good for toenails ...
Will cherry juice end pain of gout? Jan 15, 2006 Charlotte Observer, ...have less pain.". Q. I've read in your column about Vicks VapoRub and the dangers of placing it inside the nostrils. I heard once ...
Sports Briefs Jan 15, 2006 Shreveport Times, Holiday Lanes. Devin Vicks of Bossier City led the girls Senior Division (ages 15-21) with a four game total 773. Also qualifying ...
Vick murder trial testimony focuses on suspect's clothing Jan 13, 2006 Pioneer Press, ...the shooting. Both officers had been consuming alcohol and Vicks blood-alcohol content was twice the legal limit for driving. In ...
Will Horny Goat Weed solve sex problem? Dec 29, 2005 Bradenton Herald, ...life. I read a letter from a reader who used Vicks VapoRub on the soles of her child's feet to help with chest congestion and cough. ...
Throw Out Those Cough Drops, Group Says Jan 9, 2006 ABC News ...is probably an older variety antihistamine with a decongestant, such as Dimetapp Cold and Allergy Elixir, Robitussin Allergy and Cough Liquid, or Vicks NyQuil. ...
Spoonful of cold reality Jan 10, 2006 Chicago Tribune, Products with just the first of those tongue-twisting ingredients include Robitussin Maximum Strength Cough Suppressant, Vicks 44 Cough Relief, Benylin Adult ...
A Sibling Rivalry of Biblical Proportions Jan 10, 2006 New York Times, ..."I say, 'Yes,' so much that I say, 'No,' just so they can hear what the word sounds like," Winslow said, joking. Leman said: "I feel for the Vicks. ...
Booze Billionaire Sidney Frank Dies Jan 11, 2006 Forbes Tasting of root beer, black licorice and Vicks Formula 44, older Europeans had been drinking the stuff since 1935 for its medicinal purposes, rather than its ...
Drug shipped from Indy killed 5 Jan 11, 2006 Indianapolis Star, Products: Among the products containing DXM: Robitussin, Vicks 44, Tiaminic, Pertussin DM, Benylin, Alka-Seltzer Plus, Coricidin, Contac, Comtrex, Thera-Flu ...
Common cold myths confound Dec 20, 2005 Jackson Clarion Ledger, By Gary Pettus. No matter how bad her cold gets, Vonda Gordon of Jackson refuses to chow down on Vicks VapoRub. "I've heard this, but ...
Report: Cough medicine might be a sham Jan 10, 2006 Food Consumer, ...medical benefit. Examples of decongestants are Allergy Elixir, Dimetapp Cold, Robitussin Allergy, and Vicks NyQuill. The panelists ...
Glamour under the weather Jan 11, 2006 ABS CBN News, It has the same effect as paracetamol for the headache, Betadine Oral Antiseptic for the sore throat, and Vicks Vaporub for the bunged up nostrils! ...
New Guidelines Suggest Most Cough Medicines Don't Work Jan 10, 2006 WISC, ..."If you have a child, or yourself, and you're taking Nyquil or Vicks 44, and you feel better, is it placebo effect or medication effect?". ...
Derailed Senior: Fayette School System Was Right Jan 11, 2006 The Citizen.com, ...sufficient warnings. Sadly, Andy Petty may have his own perception of entitlement akin to the Marcus Vicks of the world. Simply ...
Starcom MediaVest ropes Hanmer & Partners as PR mentor Jan 11, 2006 Televisionpoint.com, Note Starcom is a leading agency and mainly handles the strategic media planning for P&G and its products like Tide, Ariel and Vicks, though it does not cater ...
Be the life-giving type Dec 27, 2005 Atlanta Journal Constitution (subscription), 3 and 4, 7 am to 8 pm. Jan 2, 10 am to 6 pm, Jan. 3 and 4, noon to 5 pm. "I was covered in Vicks so I went up like a kerosene candle," says Martinez. ...
It's All Trew: Childhood medications were simple, gave relief Dec 19, 2005 Amarillo.com (subscription), By Delbert Trew. I probably would not have survived childhood without Vicks, Mentholatum, castor oil and coal oil. These crude medications ...
`Glory Road' is a must-see event for all Jan 6, 2006 Miami Herald, What we did disproved that theory and carried over to today when you see him and you see the Michael Vicks," Flournoy said, referring to Atlanta's quarterback. ...
A needed first step to restore an image Jan 7, 2006 Virginian Pilot, ...the Vick family. If the coach doesn’t exactly owe his $2 million salary to the Vicks, he owes maybe half of it. Michael Vick thrust ...
Hokies absorb the news Jan 6, 2006 Roanoke Times, Falcons. But before the Vicks there were Bruce Smith and Jim Druckenmiller and soon there will be other greats to cheer, Shelton said. ...
Kosan Names Albert L. Kraus, Ph.D., Vice President of Regulatory ... Jan 5, 2006 Yahoo! News (press release) He also worked for Richardson Vicks, a Procter & Gamble company, for three years as a Group Leader and Section Head of Pharmacology, Toxicology and Human Safety ...
Ingredients in cold medicines replaced Jan 4, 2006 Washington Times, ...in November started selling a reformulated version of its Vicks NyQuil syrup and DayQuil and NyQuil liquid caps, replacing pseudoephedrine with acetaminophen ...
Synova Healthcare, Inc. Announces Chief Scientific Officer Jan 4, 2006 PR Newswire (press release), ...responsible for their clinical research and development programs, supporting well-known consumer brands including Metamucil(R), Pepto-Bismol(R), Vicks(R) and ...
'Christmas Reciprocity' suggestions Dec 24, 2005 2theadvocate.com, Nothing is sadder than the sight of a young warrior whose chest is draped in a Vicks VapoRub saturated towel and the rest of him swallowed in a blanket as he ...
A fresh start Jan 2, 2006 Towanda Daily Review, Just once, she sprained an ankle playing ball. "Put Vicks salve on it," the doctor ordered. She married Garland Nealis, a local boy, after high school. ...
Police say state, local agencies share blame in Bristol elderly ... Jan 8, 2006 BurlingtonFreePress.com, ...high. He remembers the stench of sewage, so overpowering that he put a dab of Vicks VapoRub under his nose to offset the smell. ...
Synova Healthcare, Inc. Announces Chief Scientific Officer Jan 4, 2006 Yahoo! News (press release) ...for their clinical research and development programs, supporting well-known consumer brands including Metamucil®, Pepto-Bismol®, Vicks® and NyQuil® to name ...
P&G Sues Co. for Alleged Copycat Products Dec 22, 2005 Houston Chronicle, | |