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Phenylbutazone
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DRUG INFO
Phenylbutazone
Drug Name:
Phenylbutazone
Indication: For the treatment of backache and ankylosing spondylitis
Pharmacology: Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Mechanism Of Action: Phenylbutazone binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.
Drug Category: Anti-inflammatory Agents; Nonsteroidal Antiinflammatory Agents (NSAIDs); ATC:M01AA01; ATC:M02AA01
Brand Names/Synonyms: 'Esteve'; A 7514; Alindor; Alka Butazolidin; Alkabutazona; Alqoverin; Ambene; Anerval; Anpuzone; Antadol; Anuspiramin; Apo-Phenylbutazone; Arthrizon; Artizin; Artrizin; Artrizone; Artropan; Azdid; Azobutyl; Azolid; B.T.Z.; Benzone; Betazed; Bizolin; Bizolin 200; Bunetzone; Busone; Buta Phen; Butacompren; Butacote; Butadion; Butadiona; Butadione; Butagesic; Butalan; Butalgina; Butalidon; Butaluy; Butapirazol; Butapirazole; Butapyrazole; Butarecbon; Butartril; Butartrina; Butatron; Butazina; Butazolidin; Butazolidine; Butazona; Butazone; Bute; Butidiona; Butiwas-Simple; Butone; Butoz; Butylpyrin; Buvetzone; Buzon; Chembutazone; Cotylbutazone; DA-192; Digibutina; Diossidone; Diozol; Diphebuzol; Diphenylbutazone; Ecobutazone; Elmedal; Equi Bute; Equipalazone; Eributazone; Exrheudon N; Febuzina; Fenartil; Fenibutal; Fenibutasan; Fenibutazona; Fenibutol; Fenilbutazona; Fenilbutina; Fenilbutine; Fenilidina; Fenotone; Fenylbutazon; Flexazone; G 13, 871; Ia-But; Intalbut; Intrabutazone; Intrazone; Ipsoflame; Kadol; Lingel; Malgesic; Mepha-Butazon; Mephabutazon; Mephabutazone; Merizone; NCI-C55414; Nadazone; Nadozone; Neo-Zoline; Novophenyl; PBZ; Phebuzin; Phebuzine; Phenbutazol; Phenbutazone; Phenopyrine; Phenyl-Mobuzon; Phenylbutaz; Phenylbutazone; Phenylbutazonum; Phenyzene; Phenyzone; Pirarreumol &Quot;B&Quot;; Pirarreumol B; Praecirheumin; Pyrabutol; Pyrazolidin; Rectofasa; Reudo; Reudox; Reumasyl; Reumazin; Reumazol; Reumune; Reumuzol; Reupolar; Robizon-V; Robizone; Robizone-V; Rubatone; Scanbutazone; Schemergin; Shigrodin; Tazone; Tencodyne; Tetnor; Tevcodyne; Therazone; Ticinil; Todalgil; Usaf Ge-15; Uzone; VAC-10; Wescozone; Zolaphen; Zolidinum; Zorane
Dosage Forms: BOLUS; LIQUID; PASTE; POWDER; SOLUTION; TABLET
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: 4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione
Chemical Formula: C19H20N2O2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00409
CAS Registry Number: 50-33-9
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Phenylbutazone News
(When available)
Mozart unites nations Dec 25, 2005
Jerusalem Post, Federico Busone has written: "The magic flute summons up several motifs - instructive, spectacular, sacred, amusing - over which reigns such a fascinating music ...
Church asks SC to review order Dec 14, 2005
Sun.Star, Earlier, Bishops Vicente Navarra of Bacolod, Patricio Buzon of Kabankalan and Jose Advincula of San Carlos wrote Chief Justice Hilario Davide asking whether or ...
Negros bishops-congressmen's forum pushed Dec 15, 2005
Visayan Daily Star, San Carlos Bishop Jose Advincula and Kabankalan Bishop Patrick Buzon were also unable to attend because of conflicts in schedule, Buenafe said. ...
University Of Connecticut Dean's List, Spring 2005 Dec 29, 2005
TheDay (subscription), Carroll DeStefano, Lauren E. Dubuque, Laura Elizabeth Hainline, Lauren M. Kallinen, Eileen M. LeMontagne, James William Mangan, Sharon Buzon Maravilla, Arminta ...
Lawyer demands SC inquiry Dec 13, 2005
Visayan Daily Star, The three bishops of Negros Occidental - Bishops Vicente Navarra of Bacolod, Patricio Buzon of Kabankalan and Jose Advincula Jr. ...
Lawyer questions SC suspension ruling Dec 13, 2005
Sun.Star, Bishops Vicente Navarra of Bacolod, Patricio Buzon of Kabankalan and Jose Advincula of San Carlos wrote Chief Justice Hilario Davide asking whether or not the ...
Exaeris, Inc., an Inyx Subsidiary, Commences Formal Operations Jan 4, 2006
Yahoo! News (press release) ...(NYSE: KG - News) and Inyx announced a 10-year strategic alliance, which includes co-marketing collaboration on King's Intal® (cromolyn sodium) and Tilade ...
Exaeris, Inc., an Inyx Subsidiary, Commences Formal Operations Jan 4, 2006
PR Newswire (press release), ...- Stephen Beckman Named President - Respiratory Sales Force Launched, Intal(R) & Tilade(R) First Products Marketed NEW YORK and EXTON, Pa., Jan. ...
Exaeris, Inc., an Inyx Subsidiary, Commences Formal Operations Jan 4, 2006
Finanzen.net, ...and Inyx announced a 10-year strategic alliance, which includes co-marketing collaboration on King's Intal(R) (cromolyn sodium) and Tilade(R) (nedocromil sodium ...
“There Were Only Local Anaesthetics Available To Amputate Limbs ... Dec 19, 2005
CounterCurrents.org, I had the opportunity to talk with him before he presented his uncensored photo and film material in a conference room of Intal[2]. ...
A young Iraqi doctor testifies on the horror in Iraq Dec 19, 2005
Center for Research on Globalization, I had the opportunity to talk with him before he presented his uncensored photo and film material in a conference room of Intal[ii][ii]. ...
Police station turns into kalyan mantap Dec 23, 2005
Newindpress, Kadol belongs to Lingayat and Priyadarshani to Jain community. Both fell in love in their college days. Both had decided to get married. ...
Howe wins a place in Sail 4 Cancer team for this year’s Olympic ... Jan 10, 2006
Bucks Free Press, Yngling, which means youngster, was invented in 1967 by Norwegian Jan Lingel for his son and it became an Olympic sport in Athens 2004. ...
RETROSPECTIVE: Jamesburg-Monroe Dec 23, 2005
Cranbury Press, They are: John Meindel, president; Kathyrn Szczepanik, vice-president; Betty Smith, secretary; Sara M. Lingel, corresponding secretary; Pearl Etsch, financial ...
Seems like yesterday Dec 18, 2005
Bothell Herald, The Silvertones was a group that took listeners on a musical trip down memory lane. Jeanette Lingel of Marysville set the tempo on the piano. ...
Stateline Area Business People in the News Dec 13, 2005
Beloit Daily News, University of Iowa. Jan Lingel, who has been with the company in various administrative positions sine 1987, has been promoted to buyer.
Packaging Has Something To Shout About At Food & Drink World 06 16 Jan 2006
Packaging & Converting Essentials (press release), ...of the seminar programme include Retail Ready Packaging supported by the Grocer; the Appliance of Science Sessions supported by PIRA International, and ...
CIAMPI: CULTIVATE DIALOGUE, LA PIRA AN EXAMPLE Jan 11, 2006
Agenzia Giornalistica Italia, ...(AGI) - Ragusa, Jan 11 - Showing politicians the way of dialogue Ciampi reminded of Giorgio La Pira, born in the province of Ragusa, "one of the great Italians ...
TUSCANY REGION: LA PIRA PRIZE TO GERMAN JURIST Jan 10, 2006
Agenzia Giornalistica Italia, 9 - In the name of Giorgio La Pira and on an important date in memory of the former Mayor of Florence engaged in the fight for peace and justice (and born on 9 ...
Half PIRA seem to be British agents, says O’Dea Dec 20, 2005
NewsHound (subscription), By Jimmy Woulfe, Mid-West Correspondent. DEFENCE Minister Willie O’Dea said yesterday it seemed that about ‘half the Provisional ...
More groups vie for CTPL Jan 11, 2006
Manila Standard Today, Ramon Dimacali, chairman of Philippine Insurers and Reinsurers Association Inc. (Pira), told a press briefing that the establishment of the compulsory third ...
Sheriff's Council audit may start today Jan 13, 2006
Lompoc Record, Five former presidents of the Sheriff's Council - Alan Cavaletto, Dale Grimm, James Petrovich, Charles Pira and Richard Miller - filed suit Dec. ...
Is IC’s Escobillo ‘lawyering’ for insurance firms? Dec 26, 2005
Manila Standard Today, ...the Insurance Commission, has not given the go-ahead to the scheme which is being proposed by the Philippine Insurers and Reinsurers Association or Pira. ...
Among Friends Dec 21, 2005
New York Sun, DOLCETTO D'ALBA 2004, LUIGI PIRA One of Italy's most pleasing red wines comes from the dolcetto grape variety that is grown almost exclusively in the Piedmont ...
Ceasefire breakdown seen as propaganda opportunity Dec 28, 2005
Guardian Unlimited, ...from army headquarters in Lisburn in July, marked "secret", said: "We have seen many reports during the last six months indicating that PIRA [Provisional IRA ...
Two SD cops cleared in death of suspect Dec 23, 2005
San Diego Union Tribune, Officers Carl Pira and Esmeralda Tagaban were sent to the hotel after residents complained that Camba was yelling and disturbing them, according to a letter ...
Insurance companies support clearinghouse system Dec 25, 2005
Manila Standard Today, Members of the Philippine Insurers and Reinsurers Association (PIRA) expressed support to government’s move to create a clearinghouse for motor vehicle ...
In the endless flow of holiday wines, these two stand out Dec 25, 2005
OregonLive.com, Dolcetto d'Alba 2004, Luigi Pira: The red grape variety called dolcetto (pronounced dole-CHEH-toe) has a curious up-and-down romance with American wine lovers ...
Collusion: sauce for the gander? Dec 21, 2005
Slugger O'Toole, ...(1) It’s no surprise (ie true) that Donaldson was a double agent and that the PIRA indeed had him also spying for them, and that SF must have known. ...
Between Illusion and Reality Jan 1, 2006
NewsBlaze, Whether they operationally will go the route of the Provisional Irish Republican Army (PIRA) in Ulster, actually decommissioning their arms, remains to be seen ...
Quarrels Overshadow Talk of Consensus Jan 4, 2006
Inter Press Service (subscription), ...issues for us are those of Kirkuk and other articles of the Iraqi constitution ratified last October regarding Kurdish rights," Sa'di Ahmad Pira, a senior ...
Forecasting Oil Supply And Demand: Difficulties And Challenges Jan 9, 2006
Middle East Economic Survey, ...different groups. For example, it is difficult to make comparisons among the forecasts of the EIA, the IEA, PIRA, PEL, and others. They ...
More benefits for sea passengers eyed Dec 25, 2005
Manila Standard Today, Escobillo said the IC is now talking with members of the Philippine Insurers and Reinsurers Association (PIRA) that insure properties, vehicles, marine vessels ...
IRA 'carefully infiltrated parts of Army' Dec 29, 2005
NewsHound (subscription), The document also claims the PIRA was assured of the total withdrawal of all British forces from the North and in return undertook to await the result of the ...
Sifting through Sunningdale Dec 31, 2005
Sunday Business Post, O'Connell, according to Rees, “was [still] clearly in touch with the PIRA [Provisional IRA] at some level'‘, but Rees said secretly that “in all his ...
British government refused to share identities of Dublin bombing ... Jan 2, 2006
NewsHound (subscription), ...“The Protestant community, rather than necessarily feeling fear, are frustrated in their suspicions that the PIRA [the Provisional IRA] are winning by ...
VineGuy and VineGal - Wine resolutions - Scott and Cindy Greenberg Jan 4, 2006
Washington Examiner, Cimbolo, Umbria, Italy ($30) should go great with pasta smothered with Grandpa Jules' almost famous Bolognese sauce while the 2001 Luigi Pira Barolo, Piedmont ...
Tribunal hears of alleged campaign of sectarian intimidation Jan 7, 2006
NewsHound (subscription), It read: “Fat Ivor PIRA scum RIP OV.�. Mr Bell said: “I took that to mean Orange Volunteers.� The same night Mr Bell had his locker broken into. ...
Second leading Shinner to be unmasked as spy Dec 18, 2005
Sunday Life, ...sources. Said one intelligence source: "There was a steady flow of information from within PIRA/PSF [Sinn Fein] from the 1970s onwards. ...
DA clears police in death following stun gun Dec 24, 2005
San Diego Union Tribune, Camba was living downtown at the Plaza Hotel on Fourth Avenue. Officers Carl Pira and Esmeralda Tagaban went there Feb. 10 because of a reported disturbance. ...
Natural gas buyers in bidding war Dec 26, 2005
Baltimore Sun, Recently, the Spanish have been willing to pay $2 to $3 per million BTUs above Gulf Coast spot prices, according to PIRA Energy Group, a New York consultant. ...
Court fight over Sheriff's Council records Dec 28, 2005
Santa Barbara News-Press (subscription), September. The lawsuit filed Friday names as plaintiffs James Petrovich, Dale Grimm, Charles Pira, Alan Cavaletto and Robert C. Miller. ...
IC says car accident premiums to hit P3b in ’06 Dec 21, 2005
Manila Standard Today, According to her, the CTPL processing center as well as members of the Philippine Insurers and Reinsurers Association (Pira) are now in the process of linking ...
Sheriff's Council leaders urge state probe Dec 21, 2005
Santa Barbara News-Press (subscription), ...concerning the Sheriff's Council," said Mr. Petrovich, who was part of the group that made the request, along with Chris Edgecomb, Chuck Pira, Alan Cavaletto ...
Gifts fill a driving need Dec 20, 2005
Yakima Herald-Republic, ...organizations. "Just because they're retirement age doesn't mean they need to be put out to pasture," said Yakima Transit planner Gary Pira. ...
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