Indication: Indicated for the treatment and management of obesity.
Pharmacology: Phentermine is indicated in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. Phentermine hydrochloride is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.
Mechanism Of Action: Phentermine is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. Phentermine (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that phentermine can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage.
Drug Category: Adrenergic Agents; Appetite Depressants; Central Nervous System Agents; Anorexigenic Agents; Stimulants; ATC:A08AA01; ATC:C01CA11
Absorption: Phentermine is rapidly absorbed after oral ingestion.
Interactions:
DrugBank: Interactions for Phentermine
Interactions for Phentermine:
Concomitant use of alcohol with phentermine hydrochloride may result in an adverse drug interaction.
Chemical IUPAC Name: 2-methyl-1-phenyl-propan-2-amine
Chemical Formula: C10H15N
Half Life: 16 to 31 hours
Drug Type: Approved Drug
# Accession No: APRD00093
CAS Registry Number: 122-09-8
Phentermine News (When available)
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