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Phenprocoumon
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DRUG INFO
Phenprocoumon
Drug Name:
Phenprocoumon
Indication: Used in the management of thromboembolic disorders
Pharmacology: Phenprocoumon, a coumarin anticoagulant, is a racemic mixture of two active isomers. It is used in the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation (AF).
Mechanism Of Action: inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.
Drug Category: Anticoagulants; ATC:B01AA04
Brand Names/Synonyms: 4oh-Coumarin Deriv.; Falithiom; Falithrom; Fencumar; Fenprocumone [Dcit]; Liquamar; Marcoumar; Marcumar; PHENPROCOUMON; Phenprocoumarol; Phenprocoumarole; Phenprocoumon Ala-Nh Deriv.; Phenprocumone; Phenprocumonum
Dosage Forms: TABLETS
Absorption: Bioavailability is close to 100%
Interactions: Not Available
Chemical IUPAC Name: 2-hydroxy-3-(1-phenylpropyl)chromen-4-one
Chemical Formula: C18H16O3
Half Life: 2.5-3.5 days
Drug Type: Approved Drug
# Accession No: APRD00228
CAS Registry Number: 435-97-2
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Phenprocoumon News
(When available)
Silica Nanotubes Loaded with Laser Dyes Dec 29, 2005
Photonics.com, ...both in Taejon; Kangwon National University in Chun-cheon; and Chonbuk National University in Chonju, made nanotubes loaded with coumarin or anthracene dye. ...
Don't want toxins in food? Then eating could be tricky Dec 18, 2005
Los Angeles Times, They include chemicals such as benzyl acetate, caffeic acid, coumarin, quercetin, and respertine — all produced by plants to defend themselves against fungi ...
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