Pharmacology: Phenoxybenzamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phenoxybenzamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phenoxybenzamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phenoxybenzamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure.
Mechanism Of Action: Phenoxybenzamine produces its therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure.
Drug Category: Vasodilator Agents; Antihypertensive Agents; ATC:C04AX02
Interactions:
DrugBank: Interactions for Phenoxybenzamine
Interactions for Phenoxybenzamine:
Dibenzyline (phenoxybenzamine hydrochloride) may interact with compounds that stimulate both alpha- and
beta- adrenergic receptors (i.e., epinephrine) to produce an exaggerated hypotensive response and
tachycardia.
Dibenzyline blocks hyperthermia production by levarterenol, and blocks hypothermia production by
reserpine.
Chemical IUPAC Name: N-benzyl-N-(2-chloroethyl)-1-phenoxy-propan-2-amine
