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Phenmetrazine
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DRUG INFO
Phenmetrazine
Drug Name:
Phenmetrazine
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Indication: Used as an anorectic in the treatment of obesity
Pharmacology: Phenmetrazine is an amphetamine-like drug. Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. Phenmetrazine was originally sold under the tradename Preludin as an anorectic. It has since been removed from the market. It is by some considered to have a greater potential for addiction than the amphetamines, and has been abused in many countries, for example Sweden.
Mechanism Of Action: Phenmetrazine is thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron leading to an increase in the release of these monoamines into the extraneuronal space. Dopamine integrates incoming sensory stimuli, initiates and controls fine movement (nigro-neostriatal pathway), controls emotional behavior (midbrain mesolimbic-forebrain system) and controls hypothalamic-pituitary endocrine system (tubero-infundibular system). It is this latter effect on the tubero-infundibular systm that seems to lead to reduced food intake. Also acts as a monoamine oxidase inhibitor.
Drug Category: Appetite Depressants; Central Nervous System Agents;
Brand Names/Synonyms: A 66; Bromadryl; Cafilon; Dexphenmetrazine; Fenmetrazin; Hydrochloride; Marsin; Mefolin; Neo-Zine; Oxazimedrine; Phenmetrazin; Phenmetrazine; Phenmetrazinum [Inn-Latin]; Preludin; Preludin Hydrochloride; Probese-P; Psychamine a 66; [Inn-Spanish]
Dosage Forms: Not Available
Absorption: Readily absorbed from gastro-intestinal tract, complete absorption after 4-6 hours
Interactions: Not Available
Chemical IUPAC Name: 3-methyl-2-phenyl-morpholine
Chemical Formula: C11H15NO
Half Life: 16-31 hours
Drug Type: Approved Drug – recently withdrawn
# Accession No: APRD00262
CAS Registry Number: 134-49-6
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