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Phenformin
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DRUG INFO
Phenformin
Drug Name:
Phenformin
Indication: For the reatment of type II diabetes mellitus
Pharmacology: Used to treat diabetes, Phenformin is a biguanide (contains 2 guanidino groups) hypoglycemic agent with actions and uses similar to those of Metformin (Glucophage). Both drugs work by (1) decreasing the absorption of glucose by the intestines, (2) decreasing the production of glucose in the liver, and by (3) increasing the body's ability to use insulin more effectively. More specifically, Phenformin improves glycemic control by improving insulin sensitivity. Phenformin is generally considered to be associated with an unacceptably high incidence of actic acidosis. In general biguanides should be used only in stable type II diabetics who are free of liver, kidney and cardiovascular problems and who cannot be controlled with diet.
Mechanism Of Action: Phenformin binds to the AMP-activated protein kinase (AMPK). AMPK is an ultra-sensitive cellular energy sensor that monitors energy consumption and down-regulates ATP-consuming processes when activated. The biguanide phenformin has been shown to independently decrease ion transport processes, influence cellular metabolism and activate AMPK. Phenformin's hypoglycemic activity is related the effect it has in activating AMPK and fooling insulin sensitive cells into thinking that insulin levels are low and causing the body to use glucose as if in a state of low caloric consumption.
Drug Category: Hypoglycemic Agents; ATC:A10BA01
Brand Names/Synonyms: Azucaps; Beta-Pebg; Beta-Phenethybiguanide; Beta-Phenethylbiguanide; CCRIS 500; Cronoformin; D Bretard; DBI; Db Comb; Db-Retard; Dbi Monohydrochloride; Debeone; Debinyl; Diabis; Dibein; Dibiraf; Dibotin; Dipar; Feguanide; Fenfoduron; Fenformin; Fenformina; Fenformina [Inn-Spanish]; Fenormin; Glukopostin; Glyphen; HSDB 3154; Insoral; Lentobetic; Meltrol; Meltrol-50; N-Phenethylbiguanide Hydrochloride; NCI-C01741; Normoglucina; Pedg; Phenethylbiguanide Hydrochloride; Phenethyldiguanide; Phenformin; Phenformin Hcl; Phenformin Hydrochloride; Phenformine; Phenformine Hcl; Phenformine [Inn-French]; Phenforminum [Inn-Latin]; Phenformix; Phenoformine Hydrochloride; Phenylethylbiguanide; Retardo; Usaf Vi-6; W 32
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: (amino-phenethylimino-methyl)iminomethanediamine
Chemical Formula: C10H15N5
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00511
CAS Registry Number: 114-86-3
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Phenformin News
(When available)
Fil-Taga sets two-day Golfer of the Year tourney Jan 14, 2006
Saipan Tribune, May B Flight), Lito Mendoza (June A Flight), Mike Cruz (June B Flight), Edgar Abalos (July A Flight), Tony Guerrero (July B Flight), William Retardo (August A ...
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