Indication: Indicated in the treatment of depression.
Pharmacology: Phenelzine belongs to a class of antidepressants called monoamine oxidase inhibitors (MAOIs). Phenelzine works by irreversibly blocking the action of a chemical substance known as monoamine oxidase (MAO) in the nervous system. Within neurons, MAO appears to regulate the levels of monoamines released upon synaptic firing. Since depression is associated with low levels of monoamines, the inhibition of MAO serves to ease depressive symptoms.
Mechanism Of Action: The irreversible inhibition of MAO by Phenelzine causes an increase in the levels of serotonin, norepinephrine, and dopamine in the neuron, relieving depressive symptoms.
Absorption: Readily absorbed after oral administration.
Interactions:
DrugBank: Interactions for Phenelzine
Interactions for Phenelzine:
In patients receiving nonselective monoamine oxidase (MOA) inhibitors in combination with serotoninergic agents
(e.g., dexfenfluramine, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafexine) there have been reports of
serious, sometimes fatal, reactions. Because Nardil is a monoamine oxidase (MAO) inhibitor, Nardil should not be used
concomitantly with a serotoninergic agent.
Chemical IUPAC Name: 2-hydrazinylethylbenzene
Chemical Formula: C8H12N2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00099
CAS Registry Number: 51-71-8
Phenelzine News (When available)
Haden Freeman to Build New Plant for Lansdowne ChemicalsDec 20, 2005 Process & Control Today, ...based chemical engineering specialist, today announced a contract win to design and develop a plant for the safe dilution and packing of Hydrazine Hydrate for ...
Op-Ed Contributor Why I'm Happy I EvolvedJan 1, 2006 New York Times, Still more fabulous is the bacterium Brocadia anammoxidans. It blithely makes a substance that to most organisms is a lethal poison - namely, hydrazine. ...
NJ blasts changes in emissions reportingDec 25, 2005 NorthJersey.com, In 2002, the state demanded answers from a Newark factory after reports of high emissions of hydrazine, a hazardous air pollutant. ...
New discoveries await out on the horizonDec 12, 2005 USA Today The spacecraft itself was filled with a full load of hydrazine fuel the day before the launch rehearsal and at press time was on track to be installed inside ...
DOV announces second Phase I trial for depression drugDec 20, 2005 DrugResearcher.com, ...that are high in tyramine must be avoided as well. The two best-known MAOI's are Phenelzine (Nardil) and Tranylcypromine (Parnate).
Sleep is the best Rx for cold, fluDec 20, 2005 Appleton Post Crescent, ...class (MAOI). Examples are isocarboxizide (Marplan), phenelzine (Nardil), tranylcypromine (Parnate) and St John' s Wort. Cough from ...
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