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Pentolinium
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DRUG INFO
Pentolinium
Drug Name:
Pentolinium
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Indication: Used to produce controlled hypotension during surgical procedures and in hypertensive crises.
Pharmacology: Acts as a ganglionic blocking agent. Pentolinium inhibits release of adrenaline and noradrenaline from adrenergic nerves. It is used as an antihypertensive, and can be administered orally, intramuscularly, and subcutaneously.
Mechanism Of Action: Binds to the nicotinic (ganglion) acetylcholine receptor. This receptor/channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. Blockage of the receptor leads to smooth muscle relaxation and vasodilaton.
Drug Category: Antihypertensive Agents
Brand Names/Synonyms: Ansolysen; Pentolinium; Pentolinium Tartrate; Pentolonium; Pentolonum
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: 1-methyl-1-[5-(1-methyl-2,3,4,5-tetrahydropyrrol-1-yl)pentyl]-2,3,4,5-tetrahydropyrrole
Chemical Formula: C15H32N2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00038
CAS Registry Number: 52-62-0
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