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Pentamidine
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DRUG INFO
Pentamidine
Drug Name:
Pentamidine
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Indication: For the treatment of pneumonia due to Pneumocystis carinii.
Pharmacology: Pentamidine is an antiprotozoal agent. It is an aromatic diamidine, and is known to have activity against Pneumocystis carinii. The exact nature of its antiprotozoal action is unknown. in vitro studies with mammalian tissues and the protozoan Crithidia oncopelti indicate that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids and proteins. Little is known about the drug's pharmacokinetics. The medication is also useful in Leishmaniasis and in prophylaxis against sleeping sickness caused by Trypanosoma brucei gambiense. Hydration before treatment lessens the incidence and severity of side effects, which include liver or kidney dysfunction, hypertension, hypotension, hypoglycemia, hypocalemia, leukopenia, thrombcytopenia, anemia, and allergic reaction. It is generally well-tolerated.
Mechanism Of Action: The mode of action of pentamidine is not fully understood. It is thought that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids, and proteins.
Drug Category: Trypanocidal Agents; Antiprotozoal Agents; Antifungal Agents; ATC:P01CX01
Brand Names/Synonyms: 4, 4'-Diamidinodiphenoxypentane; Nebupent; PNT; Pentacarinat; Pentam; Pentam 300; Pentamide; Pentamidine; Pentamidine Isethionate; Pentamidine Isetionate; Pneumopent
Dosage Forms: POWDER FOR SOLUTION
Absorption: Absorbed poorly through the gastrointestinal tract and is usually administered parenterally.
Interactions: Not Available
Chemical IUPAC Name: 4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
Chemical Formula: C19H24N4O2
Half Life: 9.1-13.2 hours
Drug Type: Approved Drug
# Accession No: APRD00303
CAS Registry Number: 100-33-4
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