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Pegvisomant
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DRUG INFO
Pegvisomant
Drug Name:
Pegvisomant
Indication: For treatment of acromegaly
Pharmacology: Somavert is used for the treatment of acromegaly, which arises from excessive IGF-1 levels. Somavert selectively binds to growth hormone (GH) receptors on cell surfaces, where it blocks the binding of endogenous GH, and thus interferes with GH signal transduction. Inhibition of GH action results in decreased serum concentrations of insulin-like growth factor-I (IGF-I), and IGF binding protein-3 (IGFBP-3). This reduces the symptoms of acromegaly.
Mechanism Of Action: Somavert selectively binds to growth hormone (GH) receptors on cell surfaces, where it blocks the binding of endogenous GH. This leads to the normalization of serum IGF-1 levels.
Drug Category: Anabolic Agents; Hormone replacement
Brand Names/Synonyms: Somatotropin precursor;Growth hormone;GH;GH-N;Pituitary growth hormone;Growth hormone 1; Somavert (Pfizer Inc)
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: PEGylated human growth hormone
Chemical Formula: C990H1532N262O300S7
Half Life: ~6 days
Drug Type: Approved Drug
# Accession No: BIOD00044
CAS Registry Number: Not Available
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Pegvisomant News
(When available)
Nautilus Moves its Long-Lasting, High Availability Human Growth ... Jan 9, 2006
PR Newswire UK (press release), ...today that it has successfully completed pharmacokinetics and therapeutic efficacy animal studies on its long-lasting human growth hormone (hGH), Vitatropin(TM ...
Can growth hormone reverse the aging process? Jan 10, 2006
Standard-Speaker, Jan. 10: NBC's Robert Bazell reports on the push of human growth hormone (hGH) on consumers as the modern-day fountain of youth. ...
Can growth hormone reverse the aging process? Jan 8, 2006
MSNBC By Judith Reichman, MD. Is human growth hormone (hGH), the long sought after fountain of youth? Dr. Judith Reichman was invited on ...
Is Growth Hormone Replacement Illegal in Deficient Adults? Dec 21, 2005
PR Newswire (press release), ...firm of Collins, McDonald & Gann, PC (http://www.cmgesq.com), recently presented a lecture entitled "Legal Update 2005: Prescribing Growth Hormone for Adult ...
Novo Nordisk Introduces New Storage Flexibility for Norditropin(R) Jan 11, 2006
Yahoo! News (press release) ...announced that Norditropin NordiFlex® (somatropin [rDNA origin] injection) 5 mg and 10 mg, the only prefilled, multi-dose, disposable growth hormone pen, can ...
Serono Completes Second Phase III Trial of its Proprietary ... Jan 8, 2006
Yahoo! News (press release) NYSE: SRA) announced today the completion of its pivotal Phase III double-blind, placebo-controlled trial of Serono's recombinant human growth hormone in the ...
Foreign Drugs May Have Same Name as US Product but Different ... Jan 12, 2006
SeniorJournal.com, Taking a different active ingredient may not help, and may even harm, the user, warns the FDA. Jan. 10, 2006 - Can growth hormone reverse the aging process? ...
Novo Nordisk Introduces New Storage Flexibility for Norditropin(R) Jan 11, 2006
PR Newswire (press release), New FDA approved growth hormone storage guidelines and expanded product line provide flexibility, choice and convenience PRINCETON, NJ, Jan. ...
Krabbe's former coach caught in drugs net again Jan 14, 2006
Scotland on Sunday, As part of the current criminal investigation, a raid on Springstein and Breuer's house produced a haul of drugs including Andriol, growth hormone and insulin ...
Lilly, Alkermes Partner on Osteoporosis Treatment Jan 9, 2006
Inside INdiana Business (press release), In 2000, Lilly and Alkermes partnered on an inhaled form of a human growth hormone and in 2001, the companies agreed to develop an inhaled insulin system. ...
Alkermes and Lilly Announce Agreement for the Development and ... Jan 9, 2006
Genetic Engineering News, ...parathyroid hormone provides an opportunity to leverage the experience we have gained from our inhaled insulin and human growth hormone collaborations," stated ...
US Federal District Court in Indianapolis Rules in Emisphere's ... Jan 9, 2006
Yahoo! News (press release) ...confidential know-how outside of the licensed field of PTH (including use of Emisphere's technology with insulins, human growth hormone, interferon follicle ...
HARPER'S INDEX Jan 15, 2006
Fort Worth Star Telegram, ...other than sex. 2: Average height gain, in inches, of adolescents who use human growth hormone over five and a half years. 8: Age ...
Time to stage a better kudocast Jan 15, 2006
Variety (subscription) ...unheeded, despite the fact that 99% of viewers don't recognize the name of a publicist at PMK/HBH, which to the untrained ear sounds like a human growth hormone ...
Newspaper Publisher Turns Cheese Maker Jan 14, 2006
Houston Chronicle, ...of it," Miller said. "They mixed it with a growth hormone that wouldn't occur in nature, and they found listeria.". Miller says he ...
Commenting on amino acids Jan 10, 2006
The South African Journal of Natural Medicine (subscription), As we age the levels of growth hormone in tissues decline. Lowered levels of growth hormone are considered to be related to ageing changes seen in people. ...
Why do some people gain weight when others don’t? Dec 15, 2005
U of M News Service (press release), It turned out that animals with high levels of growth hormone were resistant to gaining weight. Horowitz returned to his study data ...
Hopkins Researcher Links Gene Mutation With Poor Outcomes In ... Jan 9, 2006
Science Daily (press release) For Common Kind Of Dwarfism (January 11, 2001) -- A common type of dwarfism may not be principally caused by a defect in the human growth hormone gene, as ...
Salmon That Grow Up Fast Jan 10, 2006
BusinessWeek In normal salmon, the gene that controls the production of growth hormone is activated by light, so the fish generally grow only during the sunny summer months ...
Serono completes phase 3 trial of r-hGH drug for HIV-linked ... Jan 8, 2006
Forbes GENEVA (AFX) - Serono said it has completed its second phase III double-blind, placebo-controlled trial of its recombinant human growth hormone (r-hGH) to ...
Tercica Launches Increlex in the US; Only Drug Approved for the ... Jan 3, 2006
Genetic Engineering News, ...patients throughout the US, represents the first major innovation in treating children with short stature since recombinant human growth hormone was approved ...
The perils of whistleblowing Jan 6, 2006
In-PharmaTechnologist.com, Dr Rost accused Pfizer/Pharmacia of defrauding the Medicare Program by off-label promotion of Genotropin, a prescription growth hormone. ...
Theratechnologies Comments on Stock Activity Jan 9, 2006
CCNMatthews (press release), ...specified primary and major secondary endpoints in its pivotal Phase 3 double-blind, placebo-controlled trial of its recombinant human growth hormone in the ...
Antares Pharma Submits Additional Listing Application With The ... Jan 11, 2006
PharmaLive.com (press release), ...injector system is distributed in more than 30 countries for the administration of insulin and is marketed for use with human growth hormone through licensees ...
Is local the new organic? Jan 12, 2006
Grist Magazine, Even though it's not organic, there's no growth hormone used and I am supporting the last of the independent dairy farms in my state, Washington. ...
Tranzyme Pharma Receives IND Clearance for its Novel Ghrelin ... Jan 10, 2006
Genetic Engineering News, Importantly, concurrent studies in rats have demonstrated that TZP-101 does not elicit growth hormone release at gastroprokinetic doses, in contrast to other ...
5 Doping Scandal Predictions for 2006 Jan 2, 2006
NewsReleaseWire.com (press release) ...tremors, tennis players will use mild anabolics such as decadurabolin or oxandrolone, in addition to track favorites such as modafinil and growth hormone (GH). ...
Lilly, partner to develop inhalable Forteo Jan 10, 2006
Indianapolis Star, The two developed an inhaled insulin, now in late-phase testing, and an inhalable human growth hormone, which is in early-phase testing. ...
Theratechnologies says 18% stock hike may be due to Serono SA ... Jan 9, 2006
Canada.com, ...because Theratechnologies is presently recruiting patients in a Phase 3 clinical trial for a similar indication testing its growth hormone releasing factor ...
Worse Than Being Bald Jan 12, 2006
CBS News Too bad he felt like hair would really make a difference in his life because getting banned from the Olympics for using a hair growth hormone is clearly worse ...
(PRN) - Roche and Amira Pharmaceuticals Announce Innovative ... Jan 8, 2006
Bolsamania.com, ...(PRN) - Serono Completes Second Phase III Trial of its Proprietary Recombinant Human Growth Hormone for HIV-Associated Adipose Redistribution Syndrome (HARS ...
Emisphere Technologies Presentation at the 24th Annual JPMorgan ... Jan 10, 2006
Yahoo! News (press release) ...and its partners have advanced oral formulations or prototypes of salmon calcitonin, heparin, insulin, parathyroid hormone, human growth hormone and cromolyn ...
Genentech Announces Full Year and Fourth Quarter 2005 Results Jan 10, 2006
MSN Money US sales of legacy products in 2005, including growth hormone, cardiovascular products and Pulmozyme(R) (dornase alfa, recombinant) Inhalation Solution ...
LAB International common shares eligible for coverage under Quebec ... Jan 10, 2006
Canada NewsWire (press release), ...powder inhaler platform. Its pipeline also includes therapeutics for asthma, COPD, and growth hormone deficiencies. LAB Research ...
Buna man gains national attention after doctors discover a rare ... Jan 5, 2006
KBTV4.tv, ...“His particular type of tumor had the genetic code tell it to produce a certain hormone called growth hormone�, Dr. Joseph Zwrischenberger said during a ...
Doctor’s Research Gets Top Honor At National Conference Dec 28, 2005
Westchester.com, ...of children with growth disorders in the US, specifically, NCGS collects data on patients being treated with Nutropin, a growth hormone, which Genentech ...
Breast cancer drug helps height? Dec 17, 2005
myDNA.com, Each boy took tamoxifen pills twice a day for six months to two years. Six of the boys also received regular doses of growth hormone. ...
2005: A Year of Success for Plant and Animal Biotechnology Jan 4, 2006
PR Newswire (press release), Scientists estimate that just 15 of these Jersey cows could produce enough human growth hormone to meet the current world demand for the hormone. ...
European Indexes Up at Midday Jan 9, 2006
BusinessWeek Serono (SRA )(+1.45%) climbed as its recombinant human growth hormone achieved primary and secondary endpoints in a Phase III trial to treat an HIV-related ...
Genentech Announces Full Year and Fourth Quarter 2005 Results Jan 10, 2006
Yahoo! News (press release) US sales of legacy products in 2005, including growth hormone, cardiovascular products and Pulmozyme® (dornase alfa, recombinant) Inhalation Solution ...
Alkermes, Eli Lilly enter new drug pact Jan 9, 2006
BusinessWeek ...filings. Alkermes and Lilly are already collaborating on a form of inhalable insulin and a form of inhalable human growth hormone. ...
Earnings Watch Updates, advisories and surprises Jan 11, 2006
MarketWatch ...due to exocrine pancreatic insufficiency, and ALTU-238, which is a Phase II clinical trial in adults for the treatment of growth hormone deficiency. ...
(PRN) - Quest Diagnostics to Speak at the 24th Annual JPMorgan ... Jan 9, 2006
Bolsamania.com, ...[+]. (PRN) - Nautilus Moves its Long-Lasting, High Availability Human Growth Hormone Into Formal Preclinical Development ... [+.
Ambrx to Present at the 24th Annual JPMorgan Healthcare Conference Jan 10, 2006
PR Newswire (press release), ...and peptides. Ambrx's most advanced product candidate, ARX-201, is a patent-protected, long-acting human growth hormone. In preclinical ...
A roundup of editorial opinion from Michigan newspapers Jan 9, 2006
Flint Journal, US medical professionals for such use, but the drug caught on in the bodybuilding community because it was thought to enhance the production of growth hormone. ...
Ghrelin stimulates phagocytosis and superoxide production in fish ... Jan 11, 2006
Journal of Endocrinology ...kidney. Gene expression of growth hormone (GH) secretagogue-receptor (GHS-R) was detected by RT-PCR in leucocytes. Pretreatment ...
Sleep Better Tonight - Look Your Best Tomorrow Dec 19, 2005
Christian Post, Take glutamine before bed. Taking 2000 mg to 3000 mg of glutamine before bed encourages the release of growth hormone. Growth ...
68 year old American arrested for fake Viagra scam Jan 9, 2006
Think Spain, Christmas skiing holiday in the Swiss Alps. The man is also sought by the FBI for the illegal distribution of a growth hormone.
Holding on to hope Jan 10, 2006
Black Hills Pioneer, Shirleen added later that Charlie could even give himself his own growth hormone shots. "It's painful to watch your child knowing you can't do anything. ...
Experts trying to push lifespans even higher Jan 11, 2006
Asbury Park Press, ...version of the Fountain of Youth. Then human growth hormone was touted as a cure for old age. "Nothing discovered yet has been shown ...
Sports and Substance Abuse Jan 10, 2006
Medscape (subscription) ...direct testosterone analogues used in the 1930s to the use of more modern, sophisticated hormones like synthetic erythropoietin and human growth hormone (HGH). ...
Biogenerics Could Now Enter the EU Market in a Matter of Months ... Jan 3, 2006
Business Wire (press release), 2006. In the US immediate progress depends on the FDA's use of the controversial 505(b)(2) pathway for insulin and growth hormone. ...
Billie Jean King and Novo Nordisk Offer Scholarships to Young ... Jan 8, 2006
PR Web (press release), In addition, Novo Nordisk has a leading position within areas such as hemostasis management, growth hormone therapy, and hormone therapy for women.
Doctor offered cheating tips Dec 16, 2005
Myrtle Beach Sun News, ...and Shortt could "keep levels adjusted.". use of a "medium amount of growth hormone.". Short transcripts of taped interviews with ...
Sapphire Therapeutics, Inc. Builds Drug Development Team Through ... Jan 9, 2006
dBusinessNews Newark (press release), ...products. While at Merck, he co-chaired the growth hormone secretagogue project team with Sapphire founder Dr. Roy G. Smith. With ...
10 trends in technical barriers to trade Dec 27, 2005
China Economic Net, One of the most representative cases in international trade is Beef Hormone Dispute between EU and the US for beef containing growth hormone, which might bring ...
UPDATE 2-Insmed says FDA approves Iplex for growth failure Dec 12, 2005
Reuters ...is entitled to seven years of marketing exclusivity for the treatment of children with severe primary IGF-1 deficiency or with growth hormone gene deletion who ...
Court transcripts detail Walls' in-depth talk with doctor about ... Dec 14, 2005
San Jose Mercury News, ...declined comment. Shortt has pleaded not guilty to all 43 counts of illegally distributing steroids and human growth hormone. Sources ...
Palmeiro's plight part of biggest story in 2005 - steroids Jan 5, 2006
San Jose Mercury News, ...them pass the tests.". Certainly there are ways to do so. Baseball still does not test for human growth hormone. Use of insulin-like ...
Small plants loom large Jan 2, 2006
Checkbiotech.org (press release), ...described in the Nature article directs the plant to make a protein, dubbed DWF1 (for "Dwarf 1"), that is involved in the production of a plant growth hormone. ...
CEO Sets Sights on Building Shareholder Value at Theratechnologies ... Dec 15, 2005
Business Wire (press release), THG213.29 in acute renal failure, TH9507 in cystic fibrosis and TH9507 in adult growth hormone deficiency are projects that meet the value-creation criteria. ...
Supplementing teenagers? Dec 17, 2005
Malaysia Star, The growth hormone which regulated growth in childhood is supplemented with sex hormones which initiate the adolescent growth spurt. ...
US analysts: Good year expected for Teva Jan 2, 2006
Ynetnews, ...in neurological drugs and notes the drug maker is well-prepared for the potential surge of so-called generic biologic drugs, such as growth hormone and anemia ...
(PZ) Novo Nordisk Receives Subpoena Dec 20, 2005
Houston Chronicle, In addition, Novo Nordisk has a leading position within areas such as haemostasis management, growth hormone therapy and hormone replacement therapy. ...
Accused French considered suicide Jan 5, 2006
Australian, French's life was turned upside down in December 2003 when a cleaner found a bucket filled with new and used syringes, equine growth hormone, steroids and ...
Generic-Drug Makers Face a Big Year Jan 3, 2006
Los Angeles Times, ...drugs, and she notes that the drug maker is prepared for the potential surge of so-called generic biologic drugs, such as growth hormone and anemia treatments. ...
America's Weight Problem - Where Is The Pharmaceutical Industry? Dec 19, 2005
Medical News Today (press release), ...carboxypeptidase inhibitors, adipocyte 11B-hydroxysteroid dehydrogenase type 1, amylase inhibitors, synthetic human growth hormone, corticotrophin-releasing ...
How Shortt coached NFL players to cheat Dec 16, 2005
Charlotte Observer, Shortt also told Walls he “could do with a little bit of growth hormone,� which Carson said is used to build muscle mass but hasn’t been shown to have ...
Biotech company closes after running out of cash Jan 2, 2006
Checkbiotech.org (press release), ...than using genetically engineered bacteria or animal cells, which is the usual method of producing pharmaceutical proteins like insulin and growth hormone. ...
New Study Results Validate Tight Blood Sugar Control Jan 3, 2006
Yahoo! News (press release) ...specialized training enables them to be experts in the care of endocrine diseases, such as diabetes, thyroid disorders, growth hormone deficiency, osteoporosis ...
Sapphire Therapeutics, Inc.'s Oral Ghrelin Mimetic Shows Potential ... Dec 15, 2005
Genetic Engineering News, Ghrelin is a small endogenous protein that acts on the Growth Hormone Secretagogue Receptor (GHSR), recognized as a key control point in the growth hormone ...
Longtime administrator leaves dairy commission Jan 6, 2006
Capital Press (subscription), He leaves an industry facing a controversy over the use of the growth hormone bovine somatotropin and confusion over the health benefits of milk consumption. ...
Confessions of a Fake Journalist 2005: The Year in Satire Dec 30, 2005
Portsmouth Herald News, The document also alleged that on at least three separate occasions in 2003 Mr. Claus consumed egg nog laced with the Human Growth Hormone. ...
Steroid sighns in fighters Jan 3, 2006
SaddoBoxing.com ...clue look at Roys cheek bones he used steroids to after he left the middle weight division and for his fight with john ruiz he probaly took human growth hormone ...
Guide to the events of 2006 Jan 4, 2006
Morgan County Citizen, ...hospital’s Love Light Tree, and overnight the tree will grow seven feet (it will later be revealed that the fertilizers contains TGH, or tree growth hormone ...
Former Pfizer Exec Files Another Lawsuit Dec 13, 2005
Brandweek Magazine, Protection Act, among other claims, after he disclosed to Pfizer that a company it was acquiring, Pharmacia, had been marketing human growth hormone illegally. ...
International Medical Officer Dec 30, 2005
Dagens Medicin, ...our goal of being the best in our markets and making a signifi cant difference to people within the areas of diabetes, growth hormone therapy, haemostasis ...
SPORTS AND DRUGS Montgomery says he's done Dec 15, 2005
San Francisco Chronicle, He also denied ever admitting to the BALCO grand jury his use of either "the clear" or human growth hormone. But in reality, during Montgomery's Nov. ...
Athletics: 'Criminal conspiracy' of world sprint king Dec 13, 2005
Independent, ...later, Conte also accused her of doping abuse, telling the ABC television news programme 20/20 that she had administered herself with human growth hormone in a ...
Grist: The Investment Trap Dec 16, 2005
Inc.com, Yet R&D spending continues to surge. Innovation is our economy's growth hormone, and all businesses spend an increasing amount of energy in its pursuit. ...
Stimulation of pancreatic b-cell replication by incretins involves ... Dec 19, 2005
Journal of Endocrinology ...cyclase activator, forskolin, at 10 nM (~90% increase) and was additive (~170-250% increase) with the growth response to human growth hormone (hGH), indicating ...
NEWSMAKER - Doping probe ruins career of "lucky man" Montgomery Dec 13, 2005
Reuters India, The US Anti-Doping Agency had accused Montgomery of taking a cocktail of banned performance-enhancing drugs plus human growth hormone as early as 2000. ...
FDA Approves Insmed's Orphan Drug, Iplex (mecasermin rinfabate ... Dec 13, 2005
DG News ...rDNA origin) injection) for the treatment of growth failure in children with severe primary IGF-1 deficiency (Primary IGFD) or with growth hormone (GH) gene ...
CEO Sets Sights on Building Shareholder Value at Theratechnologies ... Dec 15, 2005
PharmaLive.com (press release), By applying the same value-creation criteria, we have now identified cystic fibrosis and adult growth hormone deficiency as other potential areas for ...
FDA Approvals: iPlex, Cethrin, Brivaracetam Dec 14, 2005
Medscape (subscription) ...the treatment of growth failure in children with severe primary insulin-like growth factor-1 (IGF-1) deficiency (primary IGFD) or with growth hormone (GH) gene ...
Sprinter Says Ban Is End of His Career Dec 14, 2005
Los Angeles Times, Chronicle reported in June that Montgomery told a grand jury investigating the BALCO scandal that Conte gave him regular doses of human growth hormone and THG ...
Family with a mission Dec 18, 2005
Los Angeles Daily News, ...the Byers said. Joshua receives a growth hormone shot every day. He will likely require the shots through age 18. Joshua has dental ...
Plant study could assist in cancer treatment Dec 20, 2005
Indianapolis Star, Researchers have discovered for the first time that proteins similar to multi-drug-resistant proteins in humans move a plant growth hormone into cells, said ...
Disorder leads to compulsive eating Dec 20, 2005
The News Journal, Growth hormone has been used in Prader-Willi patients over the last five to seven years to increase their growth rate and help them put on lean muscle mass ...
Update 1: Sprinter Tim Montgomery Calls It Quits Dec 15, 2005
Forbes Montgomery, however, testified that in 2001 Conte gave him weekly doses of human growth hormone and the "clear," the San Francisco Chronicle reported in June ...
Athletics: Shamed sprint king quits Dec 15, 2005
New Zealand Herald, San Francisco Chronicle last year reported that Montgomery told the grand jury that Balco founder Victor Conte gave him weekly doses of growth hormone and a ...
OU Trustees approve funding for new dorm, discuss tuition increase Dec 19, 2005
The Athens News, He credited much of the success to the university's financial stake in the Pfizer drug, Somavert(R), which treats the growth hormone disorder, acromegaly. ...
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