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Peginterferon alfa-2a
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DRUG INFO
Peginterferon alfa-2a
Drug Name:
Peginterferon alfa-2a
Indication: For treatment of hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi's sarcoma
Pharmacology: Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R.
Mechanism Of Action: Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription) which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.
Drug Category: Antiviral Agents; Immunomodulatory Agents; Antineoplastic Agents; interferons (08:18.20)
Brand Names/Synonyms: Interferon alpha-2 precursor;Interferon alpha-A;LeIF A; Pegasys (Hoffman-La Roche Inc)
Dosage Forms: SOLUTION
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: PEGylated human interferon alpha 2a
Chemical Formula: C860H1353N227O255S9
Half Life: 50-140 hrs
Drug Type: Approved Drug
# Accession No: BIOD00043
CAS Registry Number: 198153-51-4
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Peginterferon alfa-2a News
(When available)
Founder of Manhattan Associates Invests in Wandering WiFi 16 Jan 2006
Local Tech Wire, Dabbiere made the investment in Wandering WiFi through his own private investment company known as Pegasys. The amount of his investment was not disclosed. ...
Vertex's Hepatitis C Drug Has Improved Chance Of Success Jan 9, 2006
Forbes This morning Vertex said preliminary data for VX-950 showed patients had a rapid viral response to the drug when used with Pegasys, a pegylated interferon ...
Vertex Hepatitis C Treatment Show Promise in Study (Update2) Jan 9, 2006
Bloomberg Vertex designed the product to be used together with standard therapies such as Roche Holding AG's injection drug Pegasys or Schering-Plough Corp.'s injected ...
VX-950, Investigational Oral Hepatitis C Protease Inhibitor ... Jan 9, 2006
Yahoo! News (press release) ...show that VX-950, an investigational oral hepatitis C virus (HCV) protease inhibitor, dosed in combination with pegylated interferon alfa-2a (Pegasys®; peg-IFN ...
Human Genome Sciences Reports on Progress Toward Commercialization ... Jan 10, 2006
MSN Money A Phase 2B trial of Albuferon in combination with ribavirin compared to Pegasys is currently underway. ... Pegasys, in interferon- naive patients. ...
Drug Stocks Mix It Up On Guidant Bids Jan 14, 2006
Forbes ...the specialty drug firm said preliminary data for VX-950 showed patients exhibited a rapid viral response to the drug when used with Pegasys, a pegylated ...
Idenix Pharmaceuticals Reports Positive 4-Week Data From A Phase ... Jan 9, 2006
PR Newswire (press release), ...treatment arms, all involving dosing regimens of valopicitabine, administered once-daily, in combination with pegylated interferon alfa-2a (Pegasys(R)) 180 5g ...
Health Stocks in Motion Jan 9, 2006
TheStreet.com The biopharmaceutical company said partial four-week data from its Phase IIb trial of valopicitabine combined with the drug Pegasys resulted in a "rapid and ...
Guest speakers to highlight observance for Martin Luther King Jr. Jan 8, 2006
Enid News & Eagle, Devin Washington, Vance Air Force Base; Jackie Reed, Enid Public Schools; Melissa Mowrey, PEGASYS; Angela Mollette, NAACP and curator of the Southern Heights ...
Idenix Pharmaceuticals Reports Positive 4-Week Data From A Phase ... Jan 9, 2006
Yahoo! News (press release) ...(1)Davis G. et al., Liver Transplantation 2003; Vol 9, No 4:331-338 Pegasys® is a registered trademark of Hoffmann-La Roche, Inc. ...
First filing for Novartis' hep B drug Jan 4, 2006
Pharma Times (subscription), ...and Gilead's clevudine, according to Datamonitor, which adds that the newer long-acting forms of interferon alpha, notably Roche's Pegasys (peginterferon alpha ...
Getting coded on PC Dec 26, 2005
Jerusalem Post, ...which seems to me to be the reason that the popular choice for videophiles, from beginner to advanced, is TMPGEnc DVD Author (http://www.pegasys-inc.com ...
Cable dispute leaves Enid viewers scratching heads Dec 28, 2005
Enid News & Eagle, ...recently received a package from Cebridge regarding the franchise agreement it wants to enter into with the city concerning the public-access station PEGASYS. ...
Community Foundation plays Santa by giving $40,000 in grants to ... Dec 22, 2005
Enid News & Eagle, ...storage. • PEGASYS, $515.81 to help sponsor Media Day 2005, an annual event by the public-access television station. • PreventionWorkz ...
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