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Paroxetine
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DRUG INFO
Paroxetine
Drug Name:
Paroxetine
Indication: For the treatment of depression, depression accompanied by anxiety, obsessive compulsive disorder and panic attacks
Pharmacology: Paroxetine, an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) type, has no active metabolites and has the highest specificity for serotonin receptors of all the SSRIs. It is used to treat depression resistant to other antidepressants, depression complicated by anxiety, panic disorder, social and general anxiety disorder, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder, premature ejaculation, and hot flashes of menopause in women with breast cancer.
Mechanism Of Action: Paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake. Paroxetine likely inhibits the reuptake of serotonin at the neuronal membrane, enhances serotonergic neurotransmission by reducing turnover of the neurotransmitter, therefore it prolongs its activity at synaptic receptor sites and potentiates 5-HT in the CNS; paroxetine is more potent than both sertraline and fluoxetine in its ability to inhibit 5-HT reuptake. Compared to the tricyclic antidepressants, SSRIs have dramatically decreased binding to histamine, acetylcholine, and norepinephrine receptors.
Drug Category: Antidepressants; Selective Serotonin Reuptake Inhibitors (SSRIs); ATC:N06AB05
Brand Names/Synonyms: Aropax; FG 7051; Paroxetina [Inn-Spanish]; Paroxetine; Paroxetine Hcl; Paroxetine [Usan:Ban:Inn]; Paroxetinum [Inn-Latin]; Paxil; Paxil Cr; Pexeva; Seroxat
Dosage Forms: Tablet
Absorption: completely absorbed after oral dosing
Interactions: [an error occurred while processing this directive]
Chemical IUPAC Name: 3-(benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluorophenyl)-piperidine
Chemical Formula: C19H20FNO3
Half Life: 24 hours
Drug Type: Approved Drug
# Accession No: APRD00364
CAS Registry Number: 61869-08-7
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Paroxetine News
(When available)
Study of Paxil Use in Menopausal Women Jan 14, 2006
Community Dispatch (press release) By Clinicals Trials - US National Library of Medicine. To evaluate the efficacy, safety, and tolerability of Paroxetine treatment ...
Glaxo May Get US Supreme Court Hearing in Apotex Paxil Fight Jan 9, 2006
Bloomberg Jan. 9 (Bloomberg) -- The US Supreme Court signaled interest in a GlaxoSmithKline Plc bid to block a low-cost version of its Paxil antidepressant, seeking Bush ...
FDA warns pregnant women that Paxil can lead to birth defects Dec 27, 2005
Newstarget.com, FDA's director of medical policy, discusses the administration's recent warning to pregnant women regarding GlaxoSmithKline's antidepressant, Paxil, which has ...
FDA issues warning that Paxil may cause birth defects Dec 27, 2005
Newstarget.com, After reviewing two extensive studies, the FDA has issued a warning to pregnant women on the anti-depressant Paxil, claiming that the drug has been linked to ...
Suspect's sanity called into question Jan 15, 2006
Traverse City Record Eagle, ..."There's a real issue regarding the use of Paxil during that time," said Fred Gibson, Lockman's Clinton Township defense attorney. ...
The fool's gold that heals Jan 13, 2006
Guardian Unlimited, If you are Paxil and you are the only manufacturer who has the drug for social anxiety disorder, it's in your interest to broaden the category as far as ...
Witness: Mom thought killings 'right' Jan 13, 2006
St. Augustine Record, The nurse practitioner who gave her the original prescriptions changed Zoloft to Paxil, another SSRI, two days before the killings. ...
Income may influence antidepressant response Jan 13, 2006
Reuters.uk, ...status and treatment response in 248 depressed adults participating in trials of the antidepressants Pamelor (nortriptyline) or Paxil (paroxetine) combined ...
Defense puts drugs on trial Jan 12, 2006
St. Augustine Record, ...community. The theory being tested was whether certain antidepressants -- Zoloft and Paxil -- can make some people homicidal or suicidal. ...
Drug Supply Shortages Hit GlaxoSmithKline Jan 11, 2006
Forbes Shortages for several drugs such as Coreg, for high blood pressure, Avandamet, for diabetes, and Paxil CR, for depression, were reported this afternoon by ...
Antidepressant May Cause Birth Defects Jan 11, 2006
Diabetes Self Management The Food and Drug Administration (FDA) has issued a public health advisory about the antidepressant paroxetine (brand name Paxil). ...
The Generic Switch: The companies Jan 14, 2006
Newark Star Ledger, This year alone, patents will expire on some of the most widely used medicines, including a pair of antidepressants, Pfizer's Zoloft and GlaxoSmithKline's Paxil ...
Exact cause of restless legs is unknown Jan 9, 2006
Newark Star Ledger, Also, certain medications, such as the tricyclic antidepressants (ie Elavil), selective serotonin reuptake inhibitors (ie Celexa, Paxil) and decongestants, may ...
ANGELS IN LOS ANGELES Jan 1, 2006
Buffalo News, I couldn't shake the psychic terror, couldn't leave the house. My doctor prescribed an anti-anxiety drug called Paxil, and within months I was back to normal. ...
Here we go, down the hole, chasing a Part D drug plan Jan 14, 2006
Newsday, But a 30-day supply of most brand-name maintenance drugs (such as Celebrex, Paxil, Lipitor, Cardizem and Pravachol) for which there are no generics, carries co ...
TeenScreen - New York Times - Danger Signs Dec 17, 2005
OpEdNews Cecily, a recent Stanford University graduate, stabbed herself to death in the chest with a kitchen knife two weeks after she was prescribed Paxil, while her ...
Doctor calls Demeniuk 'controlling' Jan 14, 2006
St. Augustine Record, Sheppard and Thomas say Demeniuk killed her sons after mixing alcohol with Xanax, an anti-anxiety drug, and Paxil, a selective serotonin reuptake inhibitor ...
Antidepressants may reduce suicides Jan 1, 2006
International Herald Tribune, The study is likely to increase the controversy over whether depressed teenagers should routinely be prescribed newer antidepressants like Paxil and Zoloft. ...
Antidepressants appear to reduce risk of suicide Jan 1, 2006
Salt Lake Tribune, The study is likely to increase the controversy over whether depressed teenagers should routinely be prescribed newer antidepressants like Paxil and Zoloft. ...
Antidepressants cut suicidal tendencies, says study Jan 1, 2006
Earthtimes.org The study, by Group Health Cooperative (GHC) researchers, also said that new antidepressants like Paxil and Zoloft were better than older ones where low ...
A New Year’s Resolution Jan 4, 2006
PR Web (press release), Although medications such as Effexor, Prozac, Paxil, Wellbutrin, Zoloft and Celexa are considered non-addictive, there are many people who describe vast swings ...
Antidepressants Don’t Increase Suicide Risk Jan 3, 2006
Christian Broadcasting Network, But new government-sponsored studies on some of the most popular antidepressants, such as Prozac, Zoloft, Celexa, and others, such as Paxil, Lexapro, Effexor ...
The Health Report: Ring in the New Year by Understanding Your ... Jan 5, 2006
DeadBrain.us (satire) The WME recently noticed that patients were confused about antidepressants. Questions such as "What is the difference between Paxil and Pamelor? ...
Poverty Limits Efficacy of Treatment for Depression Jan 3, 2006
MedPage Today, ...investigators analyzed data from the open-label phase of two National Institute of Mental Health-funded trials of nortriptyline or Paxil (paroxetine) combined ...
Initial Results Help Clinicians Identify Patients With Treatment ... Jan 1, 2006
Science Daily (press release) Paxil Treats Major Depression In Adolescents, Study Finds (July 24, 2001) -- The largest clinical trial studying the use of antidepressants for treating major ...
ROUNDUP SkyePharma future remains clouded Jan 11, 2006
Forbes It has worked on top selling drugs such as GlaxoSmithKline PLC's Paxil CR, Novartis AG's Foradil and AstraZeneca PLC's Pulmicort. ...
Glaxo has new shortage of diabetes, heart drugs Jan 11, 2006
Reuters Coreg, Avandamet and Paxil CR, which are all experiencing some degree of shortage because of the Cidra plant issues, make up 5 percent of total Glaxo sales ...
Bags of evidence opened for Demeniuk jurors Jan 11, 2006
St. Augustine Record, They are arguing that a mix of alcohol and certain anti-depressants -- Zoloft and then Paxil -- created a "substance-induced mood disorder" that drove Demeniuk ...
Prosecution Rests, Defense Presents First Witnesses In Demeniuk ... Jan 11, 2006
News4Jax.com, Demeniuk's attorneys argued that the combination of two anti-depressants Zoloft and Paxil, along with the sedative Zantac and alcohol, contributed to her ...
'Why did I kill my babies?' Jan 10, 2006
St. Augustine Record, They both agreed she had to stop taking the medication, Ortiz said. She went to the doctor's office and changed Zoloft for Paxil. ...
The Down Side of Popping Pills Jan 11, 2006
AlterNet, Wellbutrin, Neurontin, Seroquel, Depakote, Effexor, Inderal, Trileptal, Paxil, Zyprexa, Lamictal, Abilify, I've taken them all. ...
Antidepressants May Spur Brain Cell Growth Dec 27, 2005
Forbes 27 (HealthDay News) -- Selective serotonin reuptake inhibitors (SSRIs), a widely used class of antidepressant drugs that include Celexa, Paxil, Prozac and ...
Scientists try to alter traumatic memories Dec 30, 2005
Ottawa Citizen, ...inside them out.". Prozac, Paxil or Zoloft, alone or combined with tranquillizers. Poetry, art, sculpture. Psychotherapy or "extinction ...
Top baby stories of 2005: #1 Tom Cruise and Katie Holmes Dec 30, 2005
Blogging Baby, As if Tom hadn't created enough buzz by dissing on Brooke Shields for using Paxil when she was suffering from almost lethally severe post-partum depression, he ...
Serotonin may not be key to psych drugs Dec 20, 2005
United Press International The new findings contradict the conventional wisdom on how SSRIs work, that the drugs -- including Prozac, Zoloft and Paxil -- increase synaptic concentrations ...
LIFELONG HEALTH : Joyful Christmas season can also bring ... Dec 18, 2005
Arkansas Democrat-Gazette (subscription), ...medications. The most common are drugs called serotonin reuptake inhibitors (SSRIs), such as Prozac, Paxil, Zoloft, Lexapro and Celexa. ...
SSRI antidepressants actions studied Dec 19, 2005
Webindia123, Antidepressants, such as Prozac, Zoloft and Paxil, have been thought to increase synaptic concentrations of serotonin and norepinephrine, enhancing or ...
Fifth Anniversary Of Wakefield Shooting Massacre Dec 26, 2005
CBS4Boston, ...in Wakefield. McDermott was on several medications, including Prozac and Paxil, when killed four women and three men that day. At ...
The Drug Dilemma Dec 28, 2005
ABC7Chicago.com, Antidepressants known as SSRIs pose the biggest problem. Those include drugs like Prozac, Paxil, Zoloft and Lexapro. Antihistamines ...
Alright By Donna Cummings Dec 27, 2005
Berkeley Daily Planet, ...iced tea. From the brown prescription bottle on the table I shake out a pink Paxil and swallow it with a big gulp of tea. The color ...
Good counsel: Premenstrual disorders Dec 22, 2005
Rochester Democrat and Chronicle, Medications have been found to be helpful. Antidepressants known as SSRIs, such as Sarafem, Zoloft and Paxil, are approved by the FDA to treat this condition. ...
US studies find antidepressants work for some Dec 31, 2005
MSN Money Prozac. Other antidepressants include GlaxoSmithKline's Paxil, Pfizer's Zoloft and Forest Laboratories's Celexa, among others. To ...
US studies find antidepressants work for some Dec 31, 2005
Malaysia Star, Other antidepressants include GlaxoSmithKline Plc's Paxil, Pfizer Inc's Zoloft and Forest Laboratories Inc.'s Celexa, among others. ...
Follow-up called key in treating depression Jan 1, 2006
Seattle Times, ...funded by the National Institute of Mental Health, also found the risk of suicidal behavior after starting the newer drugs — including Paxil, Zoloft, Celexa ...
Antidepressants Don't Appear to Raise Suicide Risk, Study Shows Jan 1, 2006
Bloomberg The drugs include in the original FDA warning were Effexor, Prozac, Pfizer Inc.'s Zoloft, GlaxoSmithKline Plc's Paxil, Solvay SA's Luvox, Biovail Corp.'s ...
Suicide Drops With Antidepressant Use Jan 3, 2006
FOX News The 10 drugs identified by the FDA are Prozac, Paxil, Zoloft, Effexor, Celexa, Lexapro, Luvox, Remeron, Serzone, and Wellbutrin. ...
Bring back the 40-hour workweek -- and let us take a long vacation Jan 1, 2006
Los Angeles Times, ...drug sales. Wake up and smell the Paxil. • Provide paid childbirth leave to all working Americans. Family values start here. Only ...
Depression Weighs Heaviest on the Elderly Dec 31, 2005
PakTribune.com, ...anti-depressant medications are more commonly used among the elderly: SSRIs (selective serotonin reuptake inhibitors) such as Prozac, Zoloft and Paxil; and the ...
Study counters past data linking antidepressants to increased ... Jan 1, 2006
Baltimore Sun, ...older medications known as tricyclics. The SSRIs include Prozac, Paxil, Zoloft and Celexa. Among children and adolescents, suicide ...
Herb Weisbaum: Some Encouraging News On Treating Depression Jan 5, 2006
KOMO, And it turns out; the risk of suicidal behavior was the lowest for patients taking 10 of the newest antidepressant, such as Prozac, Paxil, Zoloft, Celexa ...
TeenScreen's Pseudo-Scientific Basis Jan 6, 2006
SierraTimes.com ...disorders], clusters of symptoms presumed to be related, not diseases.� – from Prozac Backlash: Overcoming the Dangers of Prozac, Zoloft, Paxil, and other ...
Jury seated Thursday in Demeniuk trial Jan 6, 2006
St. Augustine Record, SSRI). Her Zoloft prescription was changed to Paxil, another SSRI, two days before the killings, court records revealed. Sheppard ...
Pfizer struggles as generics pummel its drugs Jan 6, 2006
Pittsburgh Post Gazette, ...share of prescriptions flatten and recently start to slip under increasing pressure from generic versions of rival brands, including Celexa, Paxil and Prozac. ...
Mental exam delays hearing Jan 5, 2006
Royal Oak Daily Tribune, Grain has been under the care of a licensed psychiatrist and takes various anti-depressant medications including Prozac and Paxil, said attorney Randy Lewis ...
Left behind by suicide, families seek answers, prevention Jan 7, 2006
Hamilton Journal News (subscription), Banks believes doctors failed her daughter, prescribing nearly two dozen medications like Oxycontin, Paxil, and Ativan that confused her mind and led to her ...
Dealing with depression in children Jan 3, 2006
News-Leader.com, ...helping?'". Poston said her son had a terrifying experience while taking the drug Paxil, becoming more depressed and aggressive. ...
Drug Companies Offer More Details on Clinical Trials Dec 28, 2005
Forbes Recent safety problems with high-profile drugs such as the antidepressant Paxil (made by GlaxoSmithKline) and the painkiller Vioxx (made by Merck) have ...
Popular Antidepressants Boost Brain Growth, Hopkins Scientists ... Dec 20, 2005
Science Daily (press release) Antidepressants, such as Prozac, Zoloft and Paxil, have long been thought to exert their clinical effects by increasing synaptic concentrations of serotonin ...
Gene Variation Affects Tamoxifen's Benefit For Breast Cancer Dec 19, 2005
Science Daily (press release) Their research has also found the antidepressant drug Paxil can prevent tamoxifen from being activated, while the antidepressant drug Effexor does not. ...
Antidepressants for Children? Dec 29, 2005
Ivanhoe, ...selective serotonin reuptake inhibitors). This includes drugs such as Prozac, Zoloft and Paxil, among others. Despite the drugs ...
Popular Antidepressants Boost Brain Growth Dec 29, 2005
Ivanhoe, Medicine. Antidepressants such as Prozac, Zoloft and Paxil have long been thought to work by increasing levels of serotonin. Koliatsos ...
Dowd takes on women in 'Sexes' Dec 17, 2005
commercialappeal.com (subscription), The pharmaceutical industry has been aggressively marketing Vicodin, Zoloft, Paxil and other products promising artificial placidity. ...
R senators choose vacation over security. Dec 22, 2005
RedState.org, ...had them in icu with exhaustion. these guys would probably have to work on paxil if they only had the 10 days the rest of us get.
DOV announces second Phase I trial for depression drug Dec 20, 2005
DrugResearcher.com, For many people, these medications are the first choice and include Fluoxetine (Prozac), Sertraline (Zoloft), Paroxetine (Paxil) and Citalopram (Celexa). ...
Breast cancer: polymorphisms in Tamoxifen metabolizing genes ... Dec 23, 2005
Xagena.it, Their research has also found the antidepressant drug Paroxetine ( Paxil ) can prevent Tamoxifen from being activated, while the antidepressant drug ...
Did a British university sell out to Procter & Gamble? Dec 22, 2005
Slate In addition to the Vioxx episode, recent reports indicate that published academic studies related to the drugs Celebrex, Paxil, and Zoloft appear to have been ...
SSRI antidepressants increase the density of nerve-impulse ... Dec 25, 2005
Xagena.it, Antidepressants, such as Prozac ( Fluoxetine ), Zoloft ( Sertraline ) and Paxil ( Paroxetine ), have long been thought to exert their clinical effects by ...
Drug Supply Shortages Hit GlaxoSmithKline Jan 11, 2006
Forbes Shortages for several drugs such as Coreg, for high blood pressure, Avandamet, for diabetes, and Paxil CR, for depression, were reported this afternoon by ...
ROUNDUP SkyePharma future remains clouded Jan 11, 2006
Forbes It has worked on top selling drugs such as GlaxoSmithKline PLC's Paxil CR, Novartis AG's Foradil and AstraZeneca PLC's Pulmicort. ...
Glaxo has new shortage of diabetes, heart drugs Jan 11, 2006
Reuters Coreg, Avandamet and Paxil CR, which are all experiencing some degree of shortage because of the Cidra plant issues, make up 5 percent of total Glaxo sales ...
Pharmaceutical Industry Marketing and Sales Veteran to Lead ... Jan 4, 2006
PharmaLive.com (press release), ...products. He led the launch of Synthon's first branded drug, Pexeva(r) (paroxetine mesylate) into the SSRI depression market. Prior ...
Drugs and electroconvulsive therapy best treatment for severe ... 16 Jan 2006
News-Medical.net, ...are often castigated in the media, and have raised both public and professional concern, antidepressants such as Prozac and Seroxat, and electroconvulsive ...
Electric shock and drugs 'are best hope for depressives' Jan 13, 2006
Times Online, TWO treatments that have been castigated in the media, electroconvulsive therapy (ECT) and antidepressants such as Prozac and Seroxat, remain the best hope for ...
SkyePharma board to replace Gowrie-Smith Jan 13, 2006
Independent, ...player in speciality pharmaceuticals development, with products including painkillers and a controlled-release version of the anti-depressant Seroxat to its ...
The fool's gold that heals Jan 13, 2006
Guardian Unlimited, ...improving by 7.34 points. People on Paxil/Seroxat improved by 9.88 points, and on the placebo arm by 6.67 points. The scores for ...
Do anti-depressants prevent orgasms? Dec 25, 2005
Ynetnews, ...to feel sexual release. Could it be related to the fact that I am currently under treatment with Seroxat? According to Dr. Liora ...
Antidepressants do not encourage suicidal tendencies: Study Jan 8, 2006
What is the Word, The current study also said that the class of drugs called as SSRIs, or Selective Serotonin Re-uptake Inhibitors of which Prozac and Seroxat are a part ...
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