Indication: Oxytetracycline is indicated for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.
Pharmacology: Oxytetracycline, a macrolide antibiotic similar to erythromycin and azithromycin, is effective against Mycobacterium avium complex (MAC) and is used for the treatment of Helicobacter pylori-associated peptic ulcer disease, community-acquired pneumonia, sinusitis, and chronic bronchitis. Oxytetracycline is also used to treat respiratory tract, sexually transmitted, otitis media, and AIDS-related infections.
Mechanism Of Action: Oxytetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.
Drug Category: Anti-bacterial Agents; Tetracyclines; ATC:D06AA03; ATC:G01AA07; ATC:J01AA06; ATC:S01AA04
Interactions:
DrugBank: Interactions for Oxytetracycline
Interactions for Oxytetracycline:
No Information Provided
Chemical IUPAC Name: 2-(amino-hydroxy-methylidene)-4-dimethylamino-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a,6,12a-hexahydrotetracene-1,3,12-trione
Chemical Formula: C22H24N2O9
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00019
CAS Registry Number: 79-57-2
Oxytetracycline News (When available)
MoA investigate cattle deathsJan 4, 2006 Republic of Botswana, ...gall bladders. He said he has administered pasturella vaccine to all the animals and terramycin to the critically ill. Kesiile said ...
Antibiotic approved for honeybee diseaseJan 6, 2006 Capital Press (subscription), Before tylosin tartrate, only one other antibiotic, oxytetracycline hydrochloride (Terramycin), was available for use against American foulbrood. ...
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