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Oxaprozin
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DRUG INFO
Oxaprozin
Drug Name:
Oxaprozin
Indication: Used to relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis.
Pharmacology: Oxaprozin is a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Oxaprozin is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain.
Mechanism Of Action: Antiinflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
Drug Category: Anti-inflammatory Agents; Nonsteroidal Antiinflammatory Agents (NSAIDs); ATC:M01AE12
Brand Names/Synonyms: Alvo; Daypro; Daypro Alta; Deflam; Oxaprozin; Oxaprozin [Usan:Ban:Inn:Jan]; Oxaprozina [Inn-Spanish]; Oxaprozine; Oxaprozine [Inn-French]; Oxaprozinum [Inn-Latin]; Oxcarbamazepine; Oxcarbazepine; Voir
Dosage Forms: TABLET
Absorption: Oxaprozin is 95% absorbed after oral administration. Food may reduce the rate of absorption of oxaprozin, but the extent of absorption is unchanged. Antacids do not significantly affect the extent and rate of oxaprozin absorption.
Interactions: Interactions for Oxaprozin:
Aspirin: Concomitant administration of Oxaprozin and aspirin is not recommended because oxaprozin displaces salicylates from plasma protein binding sites. Coadministration would be expected to increase the risk of salicylate toxicity.
Methotrexate: Coadministration of oxaprozin with methotrexate results in approximately a 36% reduction in apparent oral clearance of methotrexate. A reduction in methotrexate dosage may be considered due to the potential for increased methotrexate toxicity associated with the increased exposure.
ACE-inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. Oxaprozin has been shown to alter the pharmacokinetics of enalapril (significant decrease in dose-adjusted AUC0-24 and Cmax) and its active metabolite enalaprilat (significant increase in dose-adjusted AUC0-24). This interactionshould be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.
Furosemide: Clinical studies, as well as post marketing observations, have shown that Oxaprozin can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with NSAIDs, the patient should be observed closely for signs of renal failure (see PRECAUTIONS: Renal effects), as well as to assure diuretic efficacy.
Lithium: Coadministration of oxaprozin with lithium carbonate can cause an increase in serum lithium levels. Whenever oxaprozin is added to or removed from patients on lithium therapy, therapeutic drug monitoring of lithium levels should be performed.
Glyburide: While oxaprozin does alter the pharmacokinetics of glyburide, coadministration of oxaprozin to type II non-insulin dependent diabetic patients did not affect the area under the glucose concentration curve nor the magnitude or duration of control. However, it is advisable to monitor patientsŐ blood glucose in the beginning phase of glyburide and oxaprozin cotherapy.
Warfarin: The effects of warfarin and NSAIDs on gastrointestinal (GI) bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than that of users of either drug alone.
H2-receptor antagonists: The total body clearance of oxaprozin was reduced by 20% in subjects who concurrently received therapeutic doses of cimetidine or ranitidine; no other pharmacokinetic parameter was affected. A change of clearance of this magnitude lies within the range of normal variation and is unlikely to produce a clinically detectable difference in the outcome of therapy.
Beta-blockers: Subjects receiving 1200 mg Oxaprozin QD with 100 mg metoprolol bid exhibited statistically significant but transient increases in sitting and standing blood pressures after 14 days. Therefore, as with all NSAIDs, routine blood pressure monitoring should be considered in these patients when starting Oxaprozin therapy.
Other drugs: The coadministration of oxaprozin and antacids, acetaminophen, or conjugated estrogens resulted in no statistically significant changes in pharmacokinetic parameters in single- and/or multiple-dose studies. The interaction of oxaprozin with cardiac glycosides has not been studied.
Laboratory test interactions: False-positive urine immunoassay screening tests for benzodiazepines have been reported in patients taking Oxaprozin. This is due to lack of specificity of the screening tests. False-positive test results may be expected for several days following discontinuation of Oxaprozin therapy. Confirmatory tests, such as gas chromatography/mass spectrometry, will distinguish Oxaprozin from benzodiazepines.
Chemical IUPAC Name: 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoicacid
Chemical Formula: C18H15NO3
Half Life: 54.9 hours
Drug Type: Approved Drug
# Accession No: APRD00030
CAS Registry Number: 21256-18-8
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Oxaprozin News
(When available)
High school basketball player dies Jan 3, 2006
Chicago Tribune, Nathan, whom friends called "Alvo" because of his name and his love of NBA superstar Allen Iverson, had hit the courts twice on Monday, once at school and ...
Moving Image Centre Update December 2005 Dec 21, 2005
Scoop.co.nz (press release), ALVO NOTO ( CARSTEN NICOLAI ): Berlin based sound artist and producer Carsten Nicolai [alva noto] has established himself as a leading member in the realm of ...
New method examines cost-effectiveness of new drugs for chronic ... Jan 1, 2006
Webindia123, For some other groups of patients, such as those who did not respond well to a single agent, newer drugs such as topiramate, Oxcarbazepine, or Lamotrigine ...
Au'voir Afghanistan: A Debriefing Jan 14, 2006
Al-Jazeerah.info, By Ben Tanosborn. It caught me by surprise. After almost three years, my friend Mingo, who I believed to have gone native in his ...
Black-robed sharks prey on jury pool Jan 15, 2006
The Common Voice, This process of screening potential jurors is referred to in legal terms as voir dire, which is an Anglo-French term meaning "to speak the truth." As Judge ...
Judge won't move WR Grace trial Jan 12, 2006
The Missoulian, Molloy wrote that despite the sample of media coverage, expert analysis and the survey, he is confident an unbiased jury can be chosen by the voir dire process ...
Focus on Québec, Revamped Edition Jan 13, 2006
TravelVideo.tv (press release) Histoire de voir Québec is the title for the French-language edition, while the Spanish version is titled Vamos a ver Québec. ...
Dramatic trials and looming labour wars Jan 2, 2006
Globe and Mail, These proceedings, known as a voir dire, are to determine what evidence may be used against Mr. Pickton in the grisly case, which has attracted intense media ...
Jury duty is for Everyman - and some presidents Jan 9, 2006
Christian Science Monitor, ..."Even if [Bush] did show up, almost certainly he - like senators and other high-profile people - would be struck during voir dire," says Cal Jillson, professor ...
Irrational Games avalé par Take Two Jan 9, 2006
No Frag, C'est toujours dommage de voir un développeur indépendant se faire pacmaniser, surtout quand c'est un développeur de cette qualité. ...
22-Year-Old Jazz Singer Sophie Milman To Release Self-Titled Debut ... Jan 9, 2006
Top40-Charts.com, The beautiful and critically acclaimed jazz singer has graced the cover of New York's Forward newspaper, Voir Magazine in Montreal, Lifestyles Magazine, and ...
South Surrey EMS teacher pleads innocent Jan 11, 2006
White Rock Peace Arch News, ...will argue first over admissibility of evidence seized during the investigation. That voir dire hearing is set for Oct. 18 and 19.
Lay, Skilling Request Change of Venue -- Again Jan 5, 2006
Texas Lawyer (subscription), ...panel. The defendants also ask Lake to allow their defense lawyers to individually question prospective jurors during voir dire. ...
Discussion gets heated Dec 23, 2005
Paris News, Superville explained there are only two courtrooms in the renovated courthouse large enough to seat a voir dire panel for jury selection, and that often ...
Judge declares mistrial in drug case Jan 8, 2006
Halifax Herald (subscription), A voir dire, or trial within a trial, was held in the absence of other jurors and ended with the man’s dismissal from the jury. ...
Partez, partez vite Jan 1, 2006
de defensa, Il faut que le gouvernement en place, quel qu’il soit, n’ait plus rien à voir avec les “occupants�, et le plus vite possible. ...
Judge rejects bid to move murder trial for Larmour Dec 23, 2005
Record-Searchlight (subscription), ..."I'm not willing to abandon that," he said. "I'm not willing to throw voir dire (juror quizzing) over the side of the boat.". During ...
Top 10 stories in 2005: High court drama, local politics rule Dec 22, 2005
St. Clair Record, ..."I had never seen that occur in voir dire before in my entire career," said Matushek, of Matushek, Niles & Sinars, in a June 9 interview. ...
Water to Live By Dec 27, 2005
Winston-Salem Journal, ...happen. Road crews are finishing work on 13 bridge, road-raising and culvert projects in and around the 6,000-acre re-ser-voir site. ...
Coastal Sussex offers lots of choices to ring in new year Dec 30, 2005
The News Journal, ...information. 645-6888. House of Welsh: Live music by Lou Voir; free bar admission, but reservations are required for tables. 541-0728. ...
Abolition of Ranking: A Golden Opportunity Missed! Dec 22, 2005
Mauritius Times, Il faut voir dans quelle mesure ils ont pu faire les exercices, où ils doivent construire des phrases et faire des rédactions. ...
Triple-murder trial set for end of January Dec 31, 2005
Ironton Tribune, ...be jurors,� he said. “Then they will come back in different groups for individual voir dire (questioning). They will be asked ...
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