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Oral interferon alfa
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DRUG INFO
Oral interferon alfa
Drug Name:
Oral interferon alfa
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Indication: For the treatment of oral warts arising from HIV infection
Pharmacology: Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R.
Mechanism Of Action: Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.
Drug Category: Antiinfective; Antineoplastic
Brand Names/Synonyms: Interferon alpha-2 precursor;Interferon alpha-A;LeIF A; Veldona (Amarillo Biosciences)
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: Human interferon alpha
Chemical Formula: C860H1353N227O255S9
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: BIOD00012
CAS Registry Number: 11/1/9008
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