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Omapatrilat
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DRUG INFO
Omapatrilat
Drug Name:
Omapatrilat
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Indication: For the treatment of hypertension
Pharmacology: Omapatrilat is used to treat hypertension. Vasopeptidase inhibitor that simultaneously inhibits angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP). Omapatrilat lowers blood pressure by inhibiting the action of the angiotensin converting enzyme (ACE), which causes blood vessels to constrict. But unlike other drugs, omapatrilat also inhibits another enzyme known as neutral endopeptidase (NEP), which helps blood vessels relax. Omapatrilat demonstrated greater reduction in blood pressure than the ACE inhibitor lisinopril in individuals with salt-sensitive hypertension who typically do not respond well to ACE inhibitors.
Mechanism Of Action: Omapatrilat binds to both angiotensin converting enzyme and neutral endopeptidase. This results in a decrease renin-angiotensin-aldosterone production and increase natriuretic peptidase circulation.
Drug Category: Cardiovascular Agents; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Vasopeptidase inhibitor; Protease Inhibitors
Brand Names/Synonyms: Omapatrilat; Omapatrilat [Usan]; Vanlev
Dosage Forms: Not Available
Absorption: The absolute oral bioavailability of omapatrilat is 20% to 30% and the absorption is not affected by food intake.
Interactions: Drug Interactions for Omapatrilat
Drug and food interactions have not been observed with Omapatrilat drug. It is assumed that omapatrilat would have some of the same drug interactions as ACE inhibitors. Some common drug interaction for ACE inhibitors are: Allopurinol,
Aspirin,
Azathioprine,
Lithium,
Potassium supplements,
Potassium sparing diuretics,
and Trimethoprim.
No drug interaction were found when Warfarin was co-administered with omapatrilat.
Chemical IUPAC Name: 6-oxo-5-(3-phenyl-2-sulfanyl-propanoyl)amino-2-thia-7-azabicyclo[5.4.0]undecane-8-carboxylicacid
Chemical Formula: C19H24N2O4S2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00443
CAS Registry Number: 167305-00-2
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