Indication: For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, active benign gastric ulcer, and active duodenal ulcer.
Pharmacology: Nizatidine is a competitive, reversible inhibitor of histamine at the histamine H2-receptors, particularly those in the gastric parietal cells. By inhibiting the action of histamine on stomach cells, nizatidine reduces stomach acid production. Nizatidine had no demonstrable antiandrogenic action. Full-dose therapy for the problems treated by nizatidine lasts no longer than 8 weeks. It has been demonstrated that treatment with a reduced dose of nizatidine is effective as maintenance therapy following healing of active duodenal ulcers.
Mechanism Of Action: Nizatidine competes with histamine for binding at the H2-receptors on the gastric basolateral membrane of parietal cells. Competitive inhibition results in reduction of basal and nocturnal gastric acid secretions. The drug also decreases the gastric acid response to stimuli such as food, caffeine, insulin, betazole, or pentagastrin.
Drug Category: Anti-ulcer Agents; Histamine H2 Antagonists; ATC:A02BA04
Absorption: Rapid (bioavailability of nizatidine exceeds 70%)
Interactions:
DrugBank: Interactions for Nizatidine
Interactions for Nizatidine:
No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine,
phenytoin, and warfarin. Nizatidine does not inhibit the cytochrome P-450-linked drug-metabolizing enzyme system;
therefore, drug interactions mediated by inhibition of hepatic metabolism are not expected to occur. In patients
given very high doses (3900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150
mg b.i.d., was administered concurrently.
Chemical IUPAC Name: N-[2-[[2-(dimethylaminomethyl)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-N'-methyl-2-nitro-ethene-1,1-diamine
Chemical Formula: C12H21N5O2S2
Half Life: 1-2 hours
Drug Type: Approved Drug
# Accession No: APRD00706
CAS Registry Number: 76963-41-2
Nizatidine News (When available)
Reflux Drugs May Raise Diarrhea RiskDec 20, 2005 drkoop.com ...particularly proton pump inhibitors, such as AcipHex, Nexium, Prevacid, Prilosec and Protonix -- and H2 receptor antagonists -- such as Axid, Pepcid, Tagamet ...
Dousing the fire of acid refluxDec 13, 2005 Enid News & Eagle, ...they reduce the production of stomach acid. H2 blockers include Tagamet, Pepcid, Axid and Zantac. Other drugs that are designed to ...
Drugs as effective as surgery for acid refluxDec 15, 2005 DetNews.com, ...less likely to cause side effects. Those drugs include Axid, Pepcid, Tagamet, and Zantac. Although surgery is sometimes chosen with ...
Drugs as Effective as Surgery for Chronic RefluxDec 15, 2005 Forbes H2 receptor antagonists include Axid, Pepcid, Tagamet and Zantac. PPIs appear to have similar clinical effectiveness when compared to each another. ...
Drugs as Effective as Surgery for Management of GerdDec 16, 2005 Newswise (press release) ...headache, diarrhea, abdominal pain). Examples of H2 receptor antagonists include Axid, Pepcid, Tagamet, and Zantac. • PPIs appear to ...
Researchers Find Medications Just as Effective as Surgery in ...Dec 17, 2005 Newsinferno.com, For chronic GERD, over-the-counter H2 receptor antagonist medications (Axid, Pepcid, Tagamet, and Zantac) are not as effective as Proton Pump Inhibitors (PPIs ...
Drugs as Effective as Surgery for Chronic RefluxDec 15, 2005 HealthCentral.com Pump Inhibitors (PPIs), although PPIs have more side effects. H2 receptor antagonists include Axid, Pepcid, Tagamet and Zantac.
Zinga enters 17th District raceDec 20, 2005 Quad City Times, Andrea Zinga of Coal Valley, Ill., became the third Republican to file nomination papers with the State Board of Elections to run for Congress in Illinois ...
3 vie for chance to oppose EvansDec 20, 2005 The Register-Mail, As expected, Republican Andrea Zinga filed her nominating petitions, making it a three-way race to see who will oppose 12-term incumbent Lane Evans in November ...
Mowen believes he can win seatJan 9, 2006 Quincy Herald Whig, Republican nomination. Andrea Lane Zinga of Coal Valley is a former television journalist who was the GOP nominee in 2004. Brian ...
News briefsDec 20, 2005 New Vision, BUSIRO South MP Joseph Balikuddembe Mutebi has appealed to the government to construct ecosan toilets for residents of Bussi, Zinga and Kavanyanja islands in ...
Voters to see a few familiar namesDec 27, 2005 Bloomington Pantagraph, Back again for another run at Evans is former television anchorwoman Andrea Zinga, who watched as 62 percent of the voters went with Evans in the 2004 general ...
Three more file in governor's raceDec 20, 2005 Springfield State Journal Register, The Republicans are Andrea Zinga of Coal Valley, who was defeated by Evans in 2004, along with Jim Mowen of Rock Island and Brian Gilliland of Aledo. ...
LaHood, Evans run unopposed in primariesDec 20, 2005 Peoria Journal Star, Three Republicans will vie for the nomination to challenge him in November: Brian Gilliland of Aledo, Andrea Zinga of Coal City and Jim Mowen of Rock Island. ...
Home
Copyright phasechange.org 2006.
All Rights Reserved.
