Nitrendipine resources

DRUG INFO
Nitrendipine

Drug Name: Nitrendipine


Indication: For the treatment of mild to moderate hypertension



Pharmacology: Nitrendipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nitrendipine is similar to other peripheral vasodilators. Nitrendipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Mechanism Of Action: By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nitrendipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Drug Category: Vasodilator Agents; Antihypertensive Agents; ATC:C08CA08; Calcium Channel Blockers;

Brand Names/Synonyms: Bay E 5009; Bay-E 5009; Bayotensin; Baypress; Bylotensin; CA-212; CHEMBANK117; Deiten; N144; Nidrel; Nitrendipin; Nitrendipine; Nitrendipine [Usan:Ban:Inn:Jan]; Nitrendipine, Pharma; Nitrendipino [Inn-Spanish]; Nitrendipinum [Inn-Latin]; Nitrepin

Dosage Forms: Not Available

Absorption: Not Available

Interactions: Not Available



Chemical IUPAC Name: methylethyl2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Formula: C18H20N2O6

Half Life: Not Available

Drug Type: Approved Drug

# Accession No: APRD00421

CAS Registry Number: 39562-70-4