Indication: For the treatment of diarrhea in adults and children caused by the protozoa Giardia lamblia; For the treatment of diarrhea in children caused by the protozoa Cryptosporidium parvum
Pharmacology: Not Available
Mechanism Of Action: The antiprotozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. Studies have shown that the PFOR enzyme from Giardia lamblia directly reduces nitazoxanide by transfer of electrons in the absence of ferredoxin. The DNA-derived PFOR protein sequence of Cryptosporidium parvum appears to be similar to that of Giardia lamblia. Interference with the PFOR enzyme-dependent electron transfer reaction may not be the only pathway by which nitazoxanide exhibits antiprotozoal activity.
Interactions:
DrugBank: Interactions for Nitazoxanide
Interactions for Nitazoxanide:
Tizoxanide is highly bound to plasma protein (>99.9%). Therefore, caution should be used when administering
nitazoxanide concurrently with other highly plasma protein-bound drugs with narrow therapeutic indices, as
competition for binding sites may occur (e.g., warfarin). In vitro metabolism studies have demonstrated that
tizoxanide has no significant inhibitory effect on cytochrome P450 enzymes. Although no drug-drug interaction studies
have been conducted in vivo, it is expected that no significant interaction would occur when nitazoxanide is
co-administered with drugs that either are metabolized by or inhibit cytochrome P450 enzymes.
Chemical IUPAC Name: [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]ethanoate
Chemical Formula: C12H9N3O5S
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00558
CAS Registry Number: 55981-09-4
Nitazoxanide News (When available)
Romark to Develop Alinia (nitazoxanide) as New Treatment for ...Jan 10, 2006 PharmaLive.com (press release), 10, 2006 /PRNewswire/ -- Romark Laboratories announced that it is initiating US clinical development of Alinia(R) (nitazoxanide) tablets for treating chronic ...
Rifle girls net season’s first win while on the roadDec 13, 2005 Glenwood Springs Post Independent, ...three minutes to play. The game’s final dramatics were set up after Alinia Brennan and Aspen Peppel hit field goals. Up 64-63 ...
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