Indication: For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation
Pharmacology: Nicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Nicotine exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Nicotine is a highly addictive substance. Nicotine also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Nicotine inhalers and patches are used to treat smoking withdrawl syndrome. Nicotine is classified as a stimulant of autonomic ganglia.
Mechanism Of Action: Nicotine binds to the nicotinic acetylcholine receptor. Stimulation of nicotinic receptors leads to a variety of cholinergic and adrenergic effects; tachycardia or bradycardia mediated by either stimulation or interference with sympathetic or parasympathetic pathways, stimulation of receptors in the carotic and aortic bodies, release of epinephrine from the adrenal medulla, and stimulation of the chemoreceptor-trigger zone.
Drug Category: Anti-craving Agents; Central Nervous System Agents; Autonomic drugs; Nicotinic Agonists; ATC:N07BA01
Absorption: Absorption of nicotine through the buccal mucosa is relatively slow and the high and rapid rise followed by the decline in nicotine arterial plasma concentrations seen with cigarette smoking are not achieved with the inhaler. About 10% of absorbed nicotine is excreted unchanged in urine.
Interactions:
DrugBank: Interactions for Nicotine
Interactions for Nicotine:
Physiological changes resulting from smoking cessation, with or without nicotine replacement, may alter the
pharmacokinetics of certain concomitant medications, such as tricyclic antidepressants and theophylline. Doses of
these and perhaps other medications may need to be adjusted in patients who successfully quit smoking.
Chemical IUPAC Name: 3-(1-methylpyrrolidin-2-yl)pyridine
Chemical Formula: C10H14N2
Half Life: Cotinine has a half life of 15-20 hours, while nicotine has a half life of 1-3 hours
Province ready to help you butt outJan 12, 2006 Toronto Star, Pfizer Consumer Healthcare will supply Nicorette gum and Nicoderm patches at a discounted cost (paid by the province) and oversee their distribution. ...
Great American Smoke-Out is todayJan 5, 2006 Lewis-Clark State College, Research Center and its Campus Health Action on Tobacco Study (CHAT), Student Health will be handing out quit-smoking information, free Nicoderm patches and gum ...
Smokers Get a New Helping Hand With New Year's Quit ResolutionsDec 21, 2005 Market Wire (press release) NicoDerm® CQ® is opening up its proprietary online behavioral support program for free to help them develop their own quit strategies and give them a better ...
Ontario butts in to help people butt outJan 12, 2006 Globe and Mail, How long it lasts depends on how much the smokers chews. Pfizer's Nicoderm patch, costs roughly $30 a week. For an in-depth look at Canadian and US stocks. ...
Kicking the habit is in the cardsDec 18, 2005 Chicago Tribune, As added motivation, the cards include $50 in gift certificates for stop-smoking products, including the NicoDerm CQ patch, Commit lozenges and Nicorette gum. ...
No Smoking at Vegas this YearDec 19, 2005 Skipressworld, Las Vegas (Ski Press)-If you’re a smoker and heading you’re heading to Las Vegas for the SIA.06, you might want to stock up on Nicoderm patches before you ...
Not a first, but still a good impressionJan 6, 2006 Globe and Mail, First Impressions are from a ciggy-voiced Casablancas, who not only hasn't ceased smoking, but, from the sounds of it, has taken to puffing on Nicoderm patches ...
Exercise, diets top sellers for new yearJan 1, 2006 Florida Today, ...well in January, said Lori Lukas, a spokeswoman for GlaxoSmithKline Inc., maker of the popular over-the-counter anti-smoking aids Nicorette, Nicoderm and Commit ...
Booms and busts mark business yearJan 1, 2006 TheReporter.com, Alza - which develops drug delivery systems as well as pharmaceuticals including Concerta and Nicoderm CQ - was founded in 1968, and opened its Vacaville ...
Anti-obesity drug gets its first shotDec 20, 2005 Baxter Bulletin, ...working with retailers to verify the age of people who want to purchase OTC Xenical, an approach Glaxo already has taken with Nicorette and NicoDerm CQ, used ...
Stylish hospital staysDec 20, 2005 Indianapolis Star, As added motivation, the cards can include $50 in gift certificates for stop-smoking products, including the NicoDerm CQ patch, Commit lozenges and Nicorette ...
Smokers Get a New Helping Hand With New Year's Quit ResolutionsDec 21, 2005 Market Wire (press release) NicoDerm® CQ® is opening up its proprietary online behavioral support program for free to help them develop their own quit strategies and give them a better ...
Booms and busts mark business yearJan 1, 2006 TheReporter.com, Alza - which develops drug delivery systems as well as pharmaceuticals including Concerta and Nicoderm CQ - was founded in 1968, and opened its Vacaville ...
Kicking the habit is in the cardsDec 18, 2005 Chicago Tribune, As added motivation, the cards include $50 in gift certificates for stop-smoking products, including the NicoDerm CQ patch, Commit lozenges and Nicorette gum. ...
Anti-obesity drug gets its first shotDec 20, 2005 Baxter Bulletin, ...with retailers to verify the age of people who want to purchase OTC Xenical, an approach Glaxo already has taken with Nicorette and NicoDerm CQ, used to help ...
Stylish hospital staysDec 20, 2005 Indianapolis Star, As added motivation, the cards can include $50 in gift certificates for stop-smoking products, including the NicoDerm CQ patch, Commit lozenges and Nicorette ...
SMOKING: CAUSE OF 50 PCT OF RESPIRATORY ILLNESSESJan 11, 2006 Agenzia Giornalistica Italia, The figures have been presented as part of a new imitative by Nicorette: "reduction to stop", which involved the halving of cigarettes smoked every day to come ...
Calry woman wins Quit Smoking awardJan 10, 2006 Ocean fm, Tara Kelly beat off other ex-smokers from Offaly, Waterford, Wicklow and Louth to scoop the top prize of a holiday in the annual Nicorette Quit Awards. ...
Stick o' Joe: The taste testJan 12, 2006 OSU - The Lantern, It was concluded that Nicorette, the nicotine-enhanced chewing gum, was the standout innovation; Gass said that it has become the most popular gum in the world ...
Province ready to help you butt outJan 12, 2006 Toronto Star, Pfizer Consumer Healthcare will supply Nicorette gum and Nicoderm patches at a discounted cost (paid by the province) and oversee their distribution. ...
Glaxo plans sales curbs for diet pillJan 12, 2006 Boston Globe, Some retailers use this technique in handling the over-the-counter sales of GlaxoSmithKline's nicotine-replacement gum Nicorette. ...
Technology out-muscling rivalsDec 25, 2005 Brisbane Courier Mail, AAPT finished second across the line, 6½ hours behind Nicorette. ... Nicorette broke her mast during a sail for sponsors off Southport early in the year. ...
Australia. Rolex Sydney Hobart: Maxi yachts, damaged last year ...Dec 22, 2005 BYM News (press release), At 92 feet long, the slightly smaller Nicorette profited from both the forced retirement of Konica and the capsize of Skandia, leaving the way clear for Ludde ...
Boat by any other name would be as part of fleetDec 21, 2005 Australian, Langman is on the back foot preparing last year's line honours winner Nicorette, the canting-keeled 90-footer he has chartered from Ludde Ingvall. ...
Teens seek smoke helpDec 23, 2005 Melbourne Herald Sun, Over-the-counter products to help smokers kick the habit range from $13.50 for a 30-pack of Nicorette chewing gum, $22.95 for 36 Nicabate CQ lozenges and ...
Tassie has four entrants in Rolex Sydney HobartDec 25, 2005 Sail World, The 66-foot downwind flyer finished second across the line to Nicorette last year when skippered by Sean Langman, who this year has chartered Nicorette and is ...
Ontario butts in to help people butt outJan 12, 2006 Globe and Mail, ...will also monitor the drugs effectiveness in the quitting process. A package of Pfizer's Nicorette gum normally costs about $38 for a package of 105. ...
Diary of an Expat DownloaderJan 8, 2006 Wired News Sure, illegally downloaded sitcoms, homemade pizza and piles of Nicorette gum hardly qualify for Ernest Hemingway liver-braising debauchment. ...
On record courseDec 28, 2005 Advertiser Adelaide, ...happen.". In 2000, Cahalan became only the second woman on a line honours winner when the Swedish yacht Nicorette claimed victory.
SMOKING OUT CHARLOTTEDec 27, 2005 Mirror.co.uk, Charl recently said of her battle to give up cigs: "It's very hard because If***ing love smoking". Let's hope she got some Nicorette in her stocking.
Tasmania. Rolex Sydney Hobart: AAPT finished Hobart with broken ...Dec 28, 2005 BYM News (press release), AAPT, the former line honours winning (as Nicorette 2004) 92-footer raced by Sean Langman this year has finished 5th across the line, reaching Hobart with the ...
Kicking the habit is in the cardsDec 18, 2005 Chicago Tribune, As added motivation, the cards include $50 in gift certificates for stop-smoking products, including the NicoDerm CQ patch, Commit lozenges and Nicorette gum. ...
Alfa skipper predicts record runDec 23, 2005 Australian, Skandia, the New Zealand water-ballasted 98-footer Konica Minolta and then Sean Langman's AAPT, last year's line honours winner Nicorette, chartered from Ludde ...
Sydney to Hobart records tipped to fall in perfect weatherDec 26, 2005 Gulf Times, ...in the running are Skandia (AUS) and Konica Minolta (NZL), along with AAPT (AUS) — which took line honours last year racing under the name Nicorette. ...
Skipper fears dangerous keelsDec 18, 2005 Melbourne Herald Sun, ...to follow Skandia to the sidelines with structural damage, forcing Thwaites and his team to retire, paving the way for the canting-keeled Nicorette to come ...
Net druggists await impact of new US drug planJan 1, 2006 CTV.ca, Origins: Started in late 1999 when a young Manitoba pharmacy graduate began selling Nicorette gum, a stop-smoking aid, over Ebay at the same time another ...
Australia. Rolex Sydney Hobart: Winner takes all for Wild Oats XIJan 1, 2006 BYM News (press release), Waiting in the wings were the three leading contenders of last year's race - Konica Minolta, Skandia and the 2004 race winner Nicorette, now rebranded and ...
Defending champion’s first-up win in Sailing SouthJan 2, 2006 Sail World, Langman chose to skipper the chartered 90-footer Nicorette, racing as AAPT, in the Rolex Sydney Hobart, but yacht broke its boom and the maxi finished fifth. ...
Exercise, diets top sellers for new yearJan 1, 2006 Florida Today, ...to do well in January, said Lori Lukas, a spokeswoman for GlaxoSmithKline Inc., maker of the popular over-the-counter anti-smoking aids Nicorette, Nicoderm and ...
Businesses banking on your resolutionsJan 1, 2006 Port Huron Times Herald, Huron. "We do markedly higher amount of sales at the new year," he said of items such as Nicorette and nicotine patches. Pashenee ...
Former winner gives tipsDec 25, 2005 Advertiser Adelaide, Sean Langman, skipper of maxi AAPT, which took line honours last year as Nicorette under the guidance of Ludde Ingvall, said the Sydney to Hobart was "more ...
Maxis chase a rare trebleDec 25, 2005 Brisbane Courier Mail, Romeo and Wild Oats XI, and revamped Skandia and Konica Minolta, plus the 27m AAPT, which took line honours last year sailing as Nicorette – comprise the ...
Rare treble beckons for super maxisDec 25, 2005 TVNZ, ...of the fancied super maxis. Nicorette, comprise the largest line-up of big boats in the history of the race. With the fleet of 85 ...
Skandia leads Sydney-Hobart yacht raceDec 25, 2005 CNN International ...structural damage. Last year's line honors winner, the 90-foot Nicorette, is racing this year as AAPT, skippered by Sean Langman.
Alfa Romeo leads Sydney to Hobart fleetDec 26, 2005 The Age, Australian maxi AAPT, which took line honours last year when it was called Nicorette, was 16 miles behind the leader in fifth spot. ...
Maxis eye beers before midnightDec 26, 2005 Australian, Wild Oats powered up quickly to take a lead of four or five boat lengths from Alfa Romeo which, after its slow start, accelerated past Nicorette into clear air ...
Sydney-Hobart winner tough to pickDec 24, 2005 The Age, ...virtually on the same line of betting, well ahead of the other super maxis Skandia and Konica Minolta, with last year's line honours winner Nicorette, known as ...
Race record could go if winds help out Hobart sailorsDec 24, 2005 China Post, ...canting-keeler Skandia, the New Zealand water-ballasted Konica Minolta and AAPT, which won last year's line honors while sailing under the name Nicorette. ...
records set to be blown awayDec 24, 2005 The Age, ...to have reached Hobart, along with their slightly older big boat rivals, Skandia, Konica Minolta and AAPT2, which took line honours last year as Nicorette. ...
Canting keel boosts speed, and riskDec 23, 2005 Australian, Wharington's re-built Wild Thing and AAPT, the former Nicorette 90-footer chartered by Sean Langman for the Hobart race, have canting keels and twin foils but ...
Sydney to Hobart records at riskDec 23, 2005 Brisbane Courier Mail, ...in this race with this forecast, with line honours, the record and handicap," said Sean Langman, skipper of AAPT, which took line honours last year as Nicorette ...
Wild Oats pulling away from Alfa Romeo in Sydney HobartDec 26, 2005 Radio New Zealand, ...second New Zealand 30 metre yacht Konica Minolta is now fifth behind the Australian maxi AAPT, which took line honours last year when it was called Nicorette.
Alfa's record in doubtDec 26, 2005 Hobart Mercury, ...problems there," Spence said. AAPT2, last year's line honours champion under the guise Nicorette, also had problems. Its massive Code ...
Skipper hits back at blue water favouritesDec 21, 2005 ABC Regional Online, ...modifying the rudder to improve handling. The 27-metre maxi won line honours in last year's event, racing under the name of Nicorette.
Skipper hits back at blue water favouritesDec 21, 2005 ABC Online, The 27-metre maxi won line honours in last year's event, racing under the name of Nicorette. The blue water classic begins on Boxing Day.
Bruised Wild Oats eyes trifectaDec 28, 2005 The Mercury, It was followed three hours later by a badly damaged AAPT2 -- last year's line-honours winner as Nicorette -- which had a broken boom.
40 women contest this year's classicDec 24, 2005 FOX SPORTS, In 2000 Cahalan became only the second woman ever to be on a line-honours winner when she sailed into Hobart on the 80-footer Nicorette and is poised to become ...
Leaders close as Hobart fleet slowsDec 26, 2005 Sail World, Jervis Bay at 20:00 hours this evening was Stewart Thwaites’ Konica Minolta, while about three miles astern of her came AAPT, the former Nicorette which took ...
Fixed-keel Skandia takes third placeDec 28, 2005 Sail World, ...<:img med_3708_2_SYHO05cb_9087.jpg left :> Next to arrive was AAPT, the 92-footer which won line honours last year under the name of Nicorette. ...
Hobart Leaders on record paceDec 25, 2005 Sail World, ...her deck. She is already ten minutes behind the leader and only just ahead of Sean Longman’s AAPT, the former Nicorette. Bureau ...
Anti-obesity drug gets its first shotDec 20, 2005 Baxter Bulletin, ...suggested working with retailers to verify the age of people who want to purchase OTC Xenical, an approach Glaxo already has taken with Nicorette and NicoDerm ...
Two sleeps to HobartDec 23, 2005 Sail World, Sean Langman skipper of AAPT, the 90 footer that took line honours last year as Nicorette summed up the general feeling commented ‘A great chance for someone ...
Rolex Trophy - Rating Series ResultsDec 18, 2005 Sail World, ...after yesterday’s racing that she was withdrawing early to undergo “modifications� and with Sean Langman’s 90-footer AAPT (ex Nicorette) failing to ...
They said itDec 28, 2005 Waynesville Smoky Mountain News, ...“Instead of a smoking room, you could have a Nicorette room.� Tom Sithers, an emergency room doctor, chief of staff at Haywood Regional Medical Center ...
Boom-cracking debut breaks in race rookiesDec 29, 2005 Hobart Mercury, AAPT2 won the world's toughest ocean race last year as Nicorette and was this year the dark horse to knock off the four 98ft supermaxis for line honours. ...
Smokers Get a New Helping Hand With New Year's Quit ResolutionsDec 21, 2005 Market Wire (press release) Its more than 30 well-known brands include the leading smoking cessation products, Nicorette®, NicoDerm® and Commit®, as well as many medicine cabinet ...
Sails set for home honoursDec 19, 2005 Hobart Mercury, Contending this time with last year's winner Nicorette, which he has rebadged AAPT for the 61st Hobart, Langman has a serious shot at wowing his new clubmates. ...
Stylish hospital staysDec 20, 2005 Indianapolis Star, ...added motivation, the cards can include $50 in gift certificates for stop-smoking products, including the NicoDerm CQ patch, Commit lozenges and Nicorette gum. ...
Nicotin Products Might Harm Unborn BabyJan 2, 2006 Zaman Online, By Anadolu News Agency (aa), New York. The consumption of nicotine products during the first 12 weeks of pregnancy apparently may ...
Trees and PeopleDec 24, 2005 Napa Valley Register, ...chemicals called neonicotinoids. The "nicotin" part of the name refers to the related, naturally occurring chemical, nicotine. Some of ...
Trees and PeopleDec 24, 2005 Napa Valley Register, Concentrated nicotine alkaloid and sulfate are apparently too potent to be considered safe. The dermal LD50 for rabbits in testing was 50mg/Kg. ...
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