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Nicergoline
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DRUG INFO
Nicergoline
Drug Name:
Nicergoline
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Indication: Used to treat senile dementia;Migraines of vascular origin;Transient ischemia;Platelet hyper-aggregability;Macular degeneration
Pharmacology: Nicergoline is a potent vasodilator (improving brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. Nicergoline also improves blood circulation in the lungs and limbs and has been shown to inhibit blood platelet aggregation.
Mechanism Of Action: Nicergoline acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. Therefore the mechanism of Nicergoline is to increase vascular circulation in the brain, thereby enhancing the transmission of nerve signals across the nerve fibres, which secrete acetylcholine as a neural transmitter.
Drug Category: Nootropic Agents; Vasodilator Agents; ATC:C04AE02
Brand Names/Synonyms: FI 6714; MNE; Nargoline; Nicergolin [German]; Nicergolina [Dcit]; Nicergoline; Nicergoline [Usan:Ban:Inn:Jan]; Nicergolinum [Inn-Latin]; Nicotergoline; Nimergoline; Nimergoline Base; Sermion; Vasospan
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: Not Available
Chemical Formula: C24H26BrN3O3
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00617
CAS Registry Number: 27848-84-6
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