Indication: Naloxone is indicated for the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol.
Pharmacology: Naloxone is an opiate antagonist and prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine. Naloxone is an essentially pure narcotic antagonist, i.e., it does not possess the "agonistic" or morphine-like properties characteristic of other narcotic antagonists; Naloxone does not produce respiratory depression, psychotomimetic effects or pupillary constriction. In the absence of narcotics or agonistic effects of other narcotic antagonists, it exhibits essentially no pharmacologic activity.
Mechanism Of Action: While the mechanism of action of Naloxone is not fully understood, the preponderance of evidence suggests that Naloxone antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor. Recently, naloxone has been shown to bind all three opioid receptors (mu, kappa and gamma) but the strongest binding is to the mu receptor.
Drug Category: Antinarcotic Agents; Depressants; Opiate Antagonists; ATC:V03AB15
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Paramedic job paramount for amputeeJan 1, 2006 Chilliwack Progress, He went into respiratory arrest, and awoke later to hear a doctor telling him he’d been given narcan to counteract an overdose. ...
Paramedics ride with fire crewsDec 24, 2005 Press-Enterprise (subscription), Engine Co. 2 arrived at the home within minutes, and a paramedic gave the girl Narcan, a medication to reverse the effects of the drugs. ...
Ghost Recon Advanced WarfighterJan 6, 2006 IGN, ...currently selected weapon and ammo count. The upper right-hand corner highlights the new NarCon system. This little box shows off ...
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